Study of Atherosclerotic Risk in an Overweight Latino Adolescent Population

超重拉丁裔青少年人群的动脉粥样硬化风险研究

基本信息

项目摘要

DESCRIPTION (provided by applicant): The objective of the SOLAR (Study of Latino Adolescents at Risk) Diabetes Project, DK 59211, is to evaluate factors contributing to insulin resistance and compensatory beta-cell function in overweight Hispanic children during pubertal growth and development, and to examine mechanisms underlying changes in insulin action, insulin secretion and beta-cell function in the progression of type 2 diabetes and cardiovascular risk during this critical period. This longitudinal study directed by Dr. Goran addresses a critical adolescent health problem in overweight Latino children and may lay the foundation for prevention strategies. The wealth of information obtained during the four years has helped us to better understand factors contributing to glucose regulation in overweight Hispanic children and has served as the basis for reformulating some of our hypotheses and research directions, leading us to the objectives of the current application. Based on observations of the SOLAR study, we reported 9 out of 10 children had at least 1 risk factor for cardiovascular disease and/or type 2 diabetes, 30% had clustering of 3 or more risk factors (i.e. metabolic syndrome), and the extent of the metabolic syndrome was related to insulin resistance. Based on these observations, the current application's long-term objective is to examine the relationship between the metabolic syndrome and development of type 2 diabetes and cardiovascular disease progression. To this end,, we are measuring intima media thickness of the common carotid artery via B-mode ultrasonography, a non-invasive marker of early atherosclerosis. The specific aims of the application are: 1) To determine the associations in adiposity and metabolic parameters by CCA-IMT measurement in a cross-sectional sample of overweight Latino adolescents, 2) To assess the longitudinal changes in adiposity and metabolic risk that could be contributory to early atherosclerosis, as measured by CCA-IMT, and 3) To examine the repeated measures of CCA-IMT with various measures of adiposity and metabolic risk. PUBLIC HEALTH RELEVANCE: The relevance of this study is to give public health professionals valuable and critical information regarding cardiovascular risks to an extremely high-risk adolescent population. This knowledge will then be utilized to either create effective interventions and/or to devise new clinical methodologies regarding cardiovascular evaluations on Latino overweight youth, thus improving health, concomitant with obesity and type 2 diabetes prevention.
描述(申请人提供):SARAL(拉丁裔青少年高危研究)糖尿病项目,59211丹麦克朗,目的是评估导致超重拉美裔儿童青春期生长和发育期间胰岛素抵抗和代偿贝塔细胞功能的因素,并研究在这一关键时期胰岛素作用、胰岛素分泌和贝塔细胞功能变化在2型糖尿病进展和心血管风险中的潜在机制。这项由Goran博士领导的纵向研究解决了超重拉丁裔儿童的一个关键的青少年健康问题,并可能为预防战略奠定基础。在这四年中获得的丰富信息帮助我们更好地了解了导致超重拉美裔儿童血糖调节的因素,并作为重新制定公式的基础 我们的一些假设和研究方向,引出了我们目前应用的目标。根据太阳研究的观察,我们报告说,10个孩子中有9个至少有1个风险 心血管疾病和/或2型糖尿病的危险因素中,30%有3个或更多危险因素(即代谢综合征)聚集,代谢综合征的程度与胰岛素抵抗有关。基于这些观察,目前的应用程序的长期目标是检查代谢综合征与2型糖尿病的发展和心血管疾病进展之间的关系。为此,我们通过B型超声测量颈总动脉内膜-中层厚度,这是早期动脉粥样硬化的非侵入性标记物。这项应用的具体目的是:1)通过对超重的拉丁裔青少年的横断面样本进行CCA-IMT测量,确定肥胖和代谢参数之间的关联;2)通过CCA-IMT测量,评估可能导致早期动脉粥样硬化的肥胖和代谢风险的纵向变化;以及3)检查CCA-IMT与各种肥胖和代谢风险测量的重复测量。公共卫生相关性:这项研究的相关性是为公共卫生专业人员提供有关心血管风险的宝贵和关键信息,以帮助极高风险的青少年人口。然后,这些知识将被用于制定有效的干预措施和/或设计新的临床方法,对拉美裔超重青年进行心血管评估,从而改善健康,同时预防肥胖症和2型糖尿病。

项目成果

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Claudia Michele Toledo-Corral其他文献

Claudia Michele Toledo-Corral的其他文献

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{{ truncateString('Claudia Michele Toledo-Corral', 18)}}的其他基金

Allostatic Load in Latino Youth (ALLY) study: The Role of Discrimination and Environmental Racism
拉丁裔青年的均衡负荷 (ALLY) 研究:歧视和环境种族主义的作用
  • 批准号:
    10677710
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
Study of Atherosclerotic Risk in an Overweight Latino Adolescent Population
超重拉丁裔青少年人群的动脉粥样硬化风险研究
  • 批准号:
    7486504
  • 财政年份:
    2008
  • 资助金额:
    $ 3.5万
  • 项目类别:
Study of Atherosclerotic Risk in an Overweight Latino Adolescent Population
超重拉丁裔青少年人群的动脉粥样硬化风险研究
  • 批准号:
    7810755
  • 财政年份:
    2008
  • 资助金额:
    $ 3.5万
  • 项目类别:

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