Training Grant in Computational Genomics

计算基因组学培训补助金

• 批准号: 7497650
• 负责人: LYLE UNGAR
• 金额: $ 25.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-16 至 2009-06-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497650
• 关键词: Genomics; Grant; Training

DESCRIPTION (provided by applicant): This proposal is for the renewal of a grant to train graduate and post-doctoral students in computational biology. Over the last 10 years, the University of Pennsylvania has built a strong program for training students in genomics, bioinformatics and computational biology. The training program of this grant is part of a larger training program that also embraces four different undergraduate concentrations in mathematical and computational biology and a Master's program in Bioinformatics, and which occurs in the context of a strong collaborative research effort spanning the many disciplines involved in computational biology. Current problems in computational genomics, such as trying to understand regulatory mechanisms, require combining disparate sources of knowledge such as gene expression, promoter region and intron structure and function, and comparisons across multiple organisms. Such research requires deep understanding of the biology of the organism or phenomenon being studied, and of the experimental techniques and statistical and algorithmic methods available. The purpose of this grant is to train students with these skills and to produce researchers who will be able to address current and future research needs in computational biology. Penn has made tremendous progress in computational biology training in the last few years, as was hoped by the authors of the original training grant proposal. Penn now has a new Graduate Group, Genomics and Computational Biology (GCB) within the Biomedical Graduate Studies (BGS) program in the School of Medicine (SOM), into which we took 8 PhD (including one MD/PhD) students last year, and have 7 PhD students accepted for matriculation in the fall of 2003. While it is envisioned that graduate training support from this grant will be increasingly focused on students in GCB, we plan to continue.supporting PhD students and post docs in the Biology and the Computer and Information Science (CIS) departments, as well as in the School of Medicine. We have also added new courses serving these students, and hired two new faculty members in computational biology. Most Genomics activities at Penn fall under the umbrella of the Penn Genomics Institute (PGI). PGI provides a wide variety of computational and experimental resources including microarry facilities, proteomics facilities, hardware and software for bioinformatics, and training and consulting. All students funded by this grant will have access to these facilities. PGI includes the Penn Center for Bioinformatics (PCBI), which although mainly a research center, is significantly involved with the training program. For example, in their first year, GCB students are housed in PCBI, and students will do research rotations with PCBI faculty.

描述（由申请人提供）：该提案旨在更新一项资助，以培训计算生物学的研究生和博士后学生。在过去的十年里，宾夕法尼亚大学建立了一个强大的项目来培训学生基因组学、生物信息学和计算生物学。该资助的培训计划是一个更大的培训计划的一部分，该计划还包括数学和计算生物学的四个不同的本科专业以及生物信息学的硕士课程，并且是在跨越计算生物学涉及的许多学科的强有力的合作研究工作的背景下进行的。 当前计算基因组学的问题，例如试图理解调控机制，需要结合不同的知识来源，例如基因表达、启动子区域和内含子结构和功能，以及跨多个生物体的比较。此类研究需要深入了解所研究的生物体或现象的生物学，以及可用的实验技术和统计和算法方法。这笔赠款的目的是培训具有这些技能的学生，并培养能够满足计算生物学当前和未来研究需求的研究人员。 过去几年，宾夕法尼亚大学在计算生物学培训方面取得了巨大进步，正如最初培训拨款提案的作者所希望的那样。宾夕法尼亚大学现在在医学院 (SOM) 的生物医学研究生研究 (BGS) 项目中设立了一个新的研究生小组，即基因组学和计算生物学 (GCB)，去年我们招收了 8 名博士生（包括一名 MD/PhD），并有 7 名博士生于 2003 年秋季被录取。虽然预计这笔赠款的研究生培训支持将越来越多地集中于 GCB 的学生，但我们计划 继续支持生物学、计算机和信息科学（CIS）系以及医学院的博士生和博士后。我们还增加了为这些学生服务的新课程，并聘请了两名计算生物学方面的新教员。 宾夕法尼亚大学的大部分基因组学活动都属于宾夕法尼亚大学基因组学研究所 (PGI) 的范畴。 PGI 提供各种计算和实验资源，包括微阵列设施、蛋白质组学设施、生物信息学硬件和软件以及培训和咨询。所有受这笔补助金资助的学生都可以使用这些设施。 PGI 包括宾夕法尼亚大学生物信息学中心 (PCBI)，该中心虽然主要是一个研究中心，但也积极参与培训计划。例如，在第一年，GCB 学生被安置在 PCBI，学生将与 PCBI 教师一起进行研究轮换。