Training Grant in Molecular Cardiology

描述(由申请人提供)： 该计划旨在招募和培养内科和博士科学家成为独立的研究调查人员，他们应用重组DNA技术来阐明心血管疾病的基本机制。培训是密集和全面的，再加上从体外基因转移到转基因和敲除动物的各种生理和病理应用方面的研究经验，提供了一种更有可能确保受训者在21世纪取得成功的综合方法。该方案始于1983年，在获得AHA布格尔基金会培训补助金(1986-92年)和随后的INRSA(1992-2003年)时，总共招收了94名学员。该计划包括三年的医学博士培训和两年的博士学位。要求为每年6个职位、5个医学博士实习生和1个博士实习生提供经费。第三年将由循道卫理医院提供资金。该计划的成功体现在超过85%的毕业生留在了学术界，30人被选入全国研究竞赛，其中20人获奖。PRecepers通过培训和研究合作了十多年，在学员中拥有丰富的经验，所有学员都得到了NIH个人、SCOR或位于以下位置的项目资助：医学部的心脏病学，以及分子和人类遗传学、细胞生物学和儿科系。正在进行的研究主题包括：心血管疾病的分子遗传学；凝血和血栓形成的遗传缺陷；脂蛋白疾病的遗传学；通过生长因子、信号转导级联和转录因子调节心脏生长；基因治疗以及转基因小鼠和同源重组的使用，以阐明心脏病表型的发病机制。其他主要特点是：1)为每个受训人员提供三年受保护的研究时间；2)生物信息学、遗传学、基因工程、生物统计学和拨款撰写方面的课程；3)三个SCOR和三个计划项目的核心设施，以促进技术交流；以及4)心血管系统分子遗传学的综合研讨会。这一集成设计一直被证明是在心血管医学分子生物学领域提供成功的、独立的和具有竞争力的研究人员的有效方法。

DESCRIPTION (provided by applicant): The program is designed to recruit and prepare physician and Ph.D. scientists to become independent research investigators who apply the techniques of recombinant DNA to elucidate fundamental mechanisms of cardiovascular disease. The training is intense and comprehensive, coupled with diverse research experience in physiological and pathological applications ranging from in vitro gene transfer to transgenic and knock-out animals to provide an integrated approach more likely to assure success to the trainee in the 21st century. This program, initiated in 1983, on being awarded the AHA Bugher Foundation Training Grant (1986-92) and subsequently the INRSA (1992-2003), has enrolled a total of 94 trainees. The program consists of three years of training for the M.D. in addition to the clinical fellowship training in cardiology and two years for the PhD. Funding is requested for six positions per year, 5 for M.D. trainees and 1 for the Ph.D. trainee. The third year will be funded by The Methodist Hospital. The success of the program is shown by more than 85% of our graduates remaining in academics and 30 have been selected to participate in national research competitions with 20 winners. The Preceptors have collaborated through training and research for more than a decade, have extensive experience with trainees, all of whom are supported by NIH individual, SCOR, or program project grants located in: Cardiology in the Department of Medicine, and the Departments of Molecular and Human Genetics, Cell Biology, and Pediatrics. Ongoing research themes include: molecular genetics of cardiovascular disorders; genetic defects in coagulation and thrombosis; genetics of lipoprotein disorders; regulation of cardiac growth through growth factors, signal transduction cascades and transcription factors; gene therapy and the use of transgenic mice and homologous recombination to elucidate the pathogenesis of cardiac disease phenotypes. Other major features are: 1) three years protected research time for each trainee; 2) coursework in Bioinformatics, genetics, genetic engineering, biostatistics and grant writing; 3) core facilities of three SCORs and three Program Projects to facilitate technology exchange; and 4) an integrated seminar on molecular genetics of the cardiovascular system. This integrated design has consistently proven to be effective in providing successful independent and competitive investigators in molecular biology of cardiovascular medicine.