Histone deacetylase inhibitors and HIV latency

组蛋白脱乙酰酶抑制剂和 HIV 潜伏期

• 批准号: nhmrc : 1009533
• 负责人: Prof Melissa Churchill
• 金额: $ 40.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/histone-deacetylase-inhibitors-hiv-latency/109419
• 关键词: Histone; deacetylase; inhibitors; HIV; latency

Antiviral therapy for HIV infection has substantially reduced mortality but HIV can't be cured. This is because HIV causes a silent or latent infection in some cells. This grant will investigate a new class of drugs which show promise in reversing latent infection and potentially eliminating HIV from infected patients

艾滋病毒感染的抗病毒治疗大大降低了死亡率，但艾滋病毒是无法治愈的。这是因为艾滋病毒会在一些细胞中引起静默或潜伏的感染。这笔拨款将用于研究一类新型药物，这些药物有望逆转潜伏感染，并有可能消除感染者体内的艾滋病毒。