Elucidating the flexibility of coreceptor engagement by HIV-1 important for macrophage tropism and escape from entry inhibitors

阐明 HIV-1 与辅助受体结合的灵活性对于巨噬细胞趋向性和逃避进入抑制剂非常重要

• 批准号: nhmrc : 1006534
• 负责人: Prof Melissa Churchill
• 金额: $ 42.38万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-flexibility-coreceptor-entry-inhibitors/109190
• 关键词: Elucidating; flexibility; coreceptor; engagement; HIV

CCR5 antagonists are a new type of anti-HIV-1 drug that stops the virus from entering cells. We have evidence to suggest that the ability of CCR5 antagonists to function properly is linked to the ability of HIV-1 to infect a type of immune cell called macrophages. In this proposal, we will investigate precisely how HIV-1 enters macrophage cells, and then determine how this may influence the outcome of patients who are receiving these drugs as part of their clinical care.

CCR 5拮抗剂是一种新型的抗HIV-1药物，可以阻止病毒进入细胞。我们有证据表明，CCR 5拮抗剂正常发挥作用的能力与HIV-1感染一种称为巨噬细胞的免疫细胞的能力有关。在这项提案中，我们将精确研究HIV-1如何进入巨噬细胞，然后确定这如何影响接受这些药物作为临床护理一部分的患者的结果。