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Viral Determinants of HIV-1 Transcriptional Latency in the Central Nervous System

Viral Determinants of HIV-1 Transcriptional Latency in the Central Nervous System
中枢神经系统中 HIV-1 转录潜伏期的病毒决定因素
批准号：
nhmrc : 1051093
负责人：
Prof Melissa Churchill
金额：
$42.17万
依托单位：
Macfarlane Burnet Institute for Medical Research and Public Health
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2015-12-31
来源：
https://researchdata.edu.au/viral-determinants-hiv-central-nervous/112193
关键词：
ViralDeterminantsHIVTranscriptionalLatency

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中文摘要
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英文摘要
The anti-HIV drugs that are currently used to treat HIV-1 infection cannot eliminate the virus from the body, and therefore, cannot cure HIV-1 infection. The major reason why the drugs cannot provide a cure is because they cannot reach virus that hides in particular cells types referred to as "reservoirs". This study will determine how HIV-1 can take sanctuary in these reservoirs, which will be critical information for strategies that aim to cure HIV-1 infection.
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HIV Phenotypes Important for the Establishment of Persistent Reservoirs in the Central Nervous System and which impact Neurotropism and Neuropathogenesis
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  • 项目类别：
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  • 资助金额：
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    nhmrc : 1105962
  • 项目类别：
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  • 资助金额：
    $58.11万
  • 财政年份：
    2016
  • 负责人：
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  • 依托单位：
    RMIT University
Elucidating the flexibility of coreceptor engagement by HIV-1 important for macrophage tropism and escape from entry inhibitors
Histone deacetylase inhibitors and HIV latency
  • 批准号：
    nhmrc : 1009533
  • 项目类别：
    NHMRC Project Grants
  • 资助金额：
    $40.99万
  • 财政年份：
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  • 负责人：
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