Viral Determinants of HIV-1 Transcriptional Latency in the Central Nervous System

中枢神经系统中 HIV-1 转录潜伏期的病毒决定因素

• 批准号: nhmrc : 1051093
• 负责人: Prof Melissa Churchill
• 金额: $ 42.17万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-determinants-hiv-central-nervous/112193
• 关键词: Viral; Determinants; HIV; Transcriptional; Latency

The anti-HIV drugs that are currently used to treat HIV-1 infection cannot eliminate the virus from the body, and therefore, cannot cure HIV-1 infection. The major reason why the drugs cannot provide a cure is because they cannot reach virus that hides in particular cells types referred to as "reservoirs". This study will determine how HIV-1 can take sanctuary in these reservoirs, which will be critical information for strategies that aim to cure HIV-1 infection.

目前用于治疗HIV-1感染的抗HIV药物不能从体内消除病毒，因此不能治愈HIV-1感染。这些药物不能治愈的主要原因是它们不能到达隐藏在被称为“储库”的特定细胞类型中的病毒。这项研究将确定HIV-1如何在这些水库中避难，这将是旨在治愈HIV-1感染的战略的关键信息。