Adaptive changes in HIV-1 subtype C envelope glycoproteins contributing to pathogenicity.

HIV-1 C 亚型包膜糖蛋白的适应性变化有助于致病性。

• 批准号: nhmrc : 543133
• 负责人: Prof Melissa Churchill
• 金额: $ 28.52万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adaptive-changes-hiv-contributing-pathogenicity/81551
• 关键词: Adaptive; changes; HIV; subtype; envelope

HIV exists as multiple subtypes. The most commonly studied is type B (B-HIV). B-HIV is common in North America, Europe and Asia, but accounts for only a small fraction of HIV infections worldwide. Type C HIV (C-HIV) in Africa and Asia accounts for the majority of infections worldwide, yet very little is known about how C-HIV causes AIDS. We aim to understand how C-HIV causes AIDS. This is critical for development of drugs and vaccines specifically designed for those who are most urgently need.

艾滋病毒以多种亚型存在。研究最多的是B型(B-HIV)。B-HIV在北美、欧洲和亚洲很常见，但只占全球艾滋病毒感染的一小部分。非洲和亚洲的C型艾滋病毒(C-HIV)占全球感染人数的大多数，但对C-HIV如何导致艾滋病知之甚少。我们的目标是了解C-HIV是如何导致艾滋病的。这对于开发专门为最迫切需要的人设计的药物和疫苗至关重要。