Modeling for Heart, Lung, and Blood: From Cell to Organ

心脏、肺和血液建模：从细胞到器官

• 批准号: 7391153
• 负责人: JAMES B BASSINGTHWAIGHTE
• 金额: $ 23.22万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391153
• 关键词: Actins; Action Potentials; Address; Aerosols; Alveolar; Alveolus; Anatomic Models; Anatomy; Appendix; Archives; Area; Asthma; Basic Science; Behavior; Binding; Biochemical; Biochemical Pathway; Biological; Biological Models; Biology; Biomedical Engineering; Blood; Blood Cells; Blood Vessels; Blood capillaries; Bolus Infusion; Breathing; Carbon Dioxide; Cardiac; Cardiovascular Models; Cardiovascular Physiology; Cardiovascular system; Cell model; Cells; Cellular biology; Chest wall structure; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Code; Coffee; Collaborations; Commit; Complex; Computer Simulation; Computer Systems; Computer software; Computers; Condition; Conflict (Psychology); Consumption; Convection; Critiques; Data; Data Analyses; Data Set; Databases; Decision Making; Dependence; Depth; Development; Diagnosis; Diagnostic; Diffuse; Diffusion; Dimensions; Disease; Drug Delivery Systems; Educational process of instructing; Educational workshop; Elasticity; Electronic Mail; Electrophysiology (science); Environment; Environmental air flow; Equation; Equilibrium; Evaluation; Exclusion; Excretory function; Exercise; Exhalation; Facility Construction Funding Category; Faculty; Familiarity; Feedback; Finite Element Analysis; Gases; Generations; Genes; Genetic; Genome; Goals; Grant; Graph; Hand; Health; Hearing; Heart; Hemoglobin; Heterogeneity; Hodgkin Disease; Hour; Image; Imagery; Imaging Techniques; Indicator Dilution Techniques; Individual; Internet; Investigation; Ion Channel; Kidney; Kinetics; Knowledge; Laboratories; Language; Learning; Letters; Libraries; Life; Liquid substance; Literature; Lung; Lung Compliance; Magnetic Resonance; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Meat; Mechanics; Medical; Membrane; Membrane Potentials; Metabolic; Metabolic Diseases; Metabolism; Methods; Mission; Modeling; Molecular Conformation; Monitor; Mucous body substance; Myocardial Infarction; Myocardial perfusion; Myocardium; Myosin ATPase; Na(+)-K(+)-Exchanging ATPase; Nerve; Nitric Oxide; Noble Gases; Numbers; Occupational Exposure; Organ; Oxygen; Ozone; Paper; Partial Liquid Ventilation; Participant; Perfusion; Physics; Physiological; Physiology; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Predictive Value; Preparation; Pressoreceptors; Principal Investigator; Procedures; Process; Program Evaluation; Programming Languages; Proteins; Publications; Publishing; Pulmonary Circulation; Pulmonary Pathology; Pulmonary alveolar structure; Pump; Range; Rate; Reaction; Relative (related person); Research; Research Personnel; Residual state; Resistance; Respiratory System; Running; Sarcomeres; Schedule; Science; Score; Self Assessment; Semantics; Series; Signal Transduction; Simulate; Site; Solid; Solutions; Source; Standards of Weights and Measures; Stress; Structure; Students; Support of Research; Surveys; System; Systems Analysis; Systems Biology; Techniques; Testing; Text; Therapeutic; Time; Tissues; Training; Training Programs; Translating; Transport Reaction; Tube; Validation; Variant; Visit; Vital capacity; Vocabulary; Week; Wireless Technology; Work; Writing; analog; base; capillary; chemical reaction; clinical application; computerized tools; concept; cost; data acquisition; data modeling; day; design; design and construction; desire; discount; experience; follow-up; improved; instructor; lecturer; lectures; mathematical model; model development; multi-scale modeling; passive transport; phosphoric diester hydrolase; platform-independent; pressure; programs; receptor density; research and development; research study; respiratory; response; simulation; single photon emission computed tomography; solute; surfactant; symposium; theories; tool; uptake; voltage

DESCRIPTION (provided by applicant): This application, written in response to RFA-HL-07-002, entitled Modeling for Heart, Lung, and Blood: From Cell to Organ, is to provide training in computational modeling for investigators in the spirit of the Physiome effort, which has the goal of developing quantitative biology to improve medical science from genes to health. The program will consist of 2 courses per year, workshops at meetings, web tutorials and modeling, libraries of model programs and modeling systems for free distribution, and individual trainee follow-up training programs. The central mission is to aid investigators in developing expertise in the design of efficient experimental studies and in the analysis of data using integrative physiological models. The courses focus on applying the principles of the scientific method for designing and testing hypotheses and the use of parameterization and categorization of observations for diagnosis and therapy. The coverage ranges from the development of biophysical and biochemical level modules for cellular and subcellular systems, to whole body integrative systems for cardiovascular, respiratory and hematologic systems. Via hands on modeling from the first hour of the course using JSim a powerful but easily learned simulation system handling ordinary and partial differential equations (ODE and PDEs), stochastic models, etc., participants will learn how to examine data in order to develop hypotheses, how to convert ideas into mathematical testable model-hypotheses, how to evaluate the veracity and accuracy of computer solutions, how to design critical experiments using modeling, how to analyze data by optimization techniques providing residuals and confidence ranges for parameters, and how to evaluate validity of hypotheses and iterate the hypothesis-model- experiment-validation loop. Course participants will use software such as JSim, a platform-independent simulation analysis system, and Matlab. They will learn about simulation systems suitable for solving ODEs, Gepasi, XPPAUT, etc. and other tools, e.g. Systems Biology Workbench. Participants may also choose to return for individual training or for collaborative research. Each year the June course will emphasize elemental biophysical, physiological, and biochemical module design and construction, with application to clinical research using integrative models for positron emission tomography or magnetic resonance. Each year the September course will emphasize an application area such as cardiac or respiratory studies. Over the 4-year program we plan to provide courses and individual training for 200 participants to learn in depth, for others to train themselves using our models and tutorials on the web, and for any investigator to take these published models as starting points for their own models. The result should enhance our nation's capabilities in quantitative research analysis and improve our competitiveness in the advancement of diagnostic and therapeutic techniques.

描述（由申请人提供）：