Modeling for Heart, Lung, and Blood: From Cell to Organ

心脏、肺和血液建模：从细胞到器官

• 批准号: 7391153
• 负责人: JAMES B BASSINGTHWAIGHTE
• 金额: $ 23.22万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391153
• 关键词: Actins; Action Potentials; Address; Aerosols; Alveolar; Alveolus; Anatomic Models; Anatomy; Appendix; Archives; Area; Asthma; Basic Science; Behavior; Binding; Biochemical; Biochemical Pathway; Biological; Biological Models; Biology; Biomedical Engineering; Blood; Blood Cells; Blood Vessels; Blood capillaries; Bolus Infusion; Breathing; Carbon Dioxide; Cardiac; Cardiovascular Models; Cardiovascular Physiology; Cardiovascular system; Cell model; Cells; Cellular biology; Chest wall structure; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Code; Coffee; Collaborations; Commit; Complex; Computer Simulation; Computer Systems; Computer software; Computers; Condition; Conflict (Psychology); Consumption; Convection; Critiques; Data; Data Analyses; Data Set; Databases; Decision Making; Dependence; Depth; Development; Diagnosis; Diagnostic; Diffuse; Diffusion; Dimensions; Disease; Drug Delivery Systems; Educational process of instructing; Educational workshop; Elasticity; Electronic Mail; Electrophysiology (science); Environment; Environmental air flow; Equation; Equilibrium; Evaluation; Exclusion; Excretory function; Exercise; Exhalation; Facility Construction Funding Category; Faculty; Familiarity; Feedback; Finite Element Analysis; Gases; Generations; Genes; Genetic; Genome; Goals; Grant; Graph; Hand; Health; Hearing; Heart; Hemoglobin; Heterogeneity; Hodgkin Disease; Hour; Image; Imagery; Imaging Techniques; Indicator Dilution Techniques; Individual; Internet; Investigation; Ion Channel; Kidney; Kinetics; Knowledge; Laboratories; Language; Learning; Letters; Libraries; Life; Liquid substance; Literature; Lung; Lung Compliance; Magnetic Resonance; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Meat; Mechanics; Medical; Membrane; Membrane Potentials; Metabolic; Metabolic Diseases; Metabolism; Methods; Mission; Modeling; Molecular Conformation; Monitor; Mucous body substance; Myocardial Infarction; Myocardial perfusion; Myocardium; Myosin ATPase; Na(+)-K(+)-Exchanging ATPase; Nerve; Nitric Oxide; Noble Gases; Numbers; Occupational Exposure; Organ; Oxygen; Ozone; Paper; Partial Liquid Ventilation; Participant; Perfusion; Physics; Physiological; Physiology; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Predictive Value; Preparation; Pressoreceptors; Principal Investigator; Procedures; Process; Program Evaluation; Programming Languages; Proteins; Publications; Publishing; Pulmonary Circulation; Pulmonary Pathology; Pulmonary alveolar structure; Pump; Range; Rate; Reaction; Relative (related person); Research; Research Personnel; Residual state; Resistance; Respiratory System; Running; Sarcomeres; Schedule; Science; Score; Self Assessment; Semantics; Series; Signal Transduction; Simulate; Site; Solid; Solutions; Source; Standards of Weights and Measures; Stress; Structure; Students; Support of Research; Surveys; System; Systems Analysis; Systems Biology; Techniques; Testing; Text; Therapeutic; Time; Tissues; Training; Training Programs; Translating; Transport Reaction; Tube; Validation; Variant; Visit; Vital capacity; Vocabulary; Week; Wireless Technology; Work; Writing; analog; base; capillary; chemical reaction; clinical application; computerized tools; concept; cost; data acquisition; data modeling; day; design; design and construction; desire; discount; experience; follow-up; improved; instructor; lecturer; lectures; mathematical model; model development; multi-scale modeling; passive transport; phosphoric diester hydrolase; platform-independent; pressure; programs; receptor density; research and development; research study; respiratory; response; simulation; single photon emission computed tomography; solute; surfactant; symposium; theories; tool; uptake; voltage

DESCRIPTION (provided by applicant): This application, written in response to RFA-HL-07-002, entitled Modeling for Heart, Lung, and Blood: From Cell to Organ, is to provide training in computational modeling for investigators in the spirit of the Physiome effort, which has the goal of developing quantitative biology to improve medical science from genes to health. The program will consist of 2 courses per year, workshops at meetings, web tutorials and modeling, libraries of model programs and modeling systems for free distribution, and individual trainee follow-up training programs. The central mission is to aid investigators in developing expertise in the design of efficient experimental studies and in the analysis of data using integrative physiological models. The courses focus on applying the principles of the scientific method for designing and testing hypotheses and the use of parameterization and categorization of observations for diagnosis and therapy. The coverage ranges from the development of biophysical and biochemical level modules for cellular and subcellular systems, to whole body integrative systems for cardiovascular, respiratory and hematologic systems. Via hands on modeling from the first hour of the course using JSim a powerful but easily learned simulation system handling ordinary and partial differential equations (ODE and PDEs), stochastic models, etc., participants will learn how to examine data in order to develop hypotheses, how to convert ideas into mathematical testable model-hypotheses, how to evaluate the veracity and accuracy of computer solutions, how to design critical experiments using modeling, how to analyze data by optimization techniques providing residuals and confidence ranges for parameters, and how to evaluate validity of hypotheses and iterate the hypothesis-model- experiment-validation loop. Course participants will use software such as JSim, a platform-independent simulation analysis system, and Matlab. They will learn about simulation systems suitable for solving ODEs, Gepasi, XPPAUT, etc. and other tools, e.g. Systems Biology Workbench. Participants may also choose to return for individual training or for collaborative research. Each year the June course will emphasize elemental biophysical, physiological, and biochemical module design and construction, with application to clinical research using integrative models for positron emission tomography or magnetic resonance. Each year the September course will emphasize an application area such as cardiac or respiratory studies. Over the 4-year program we plan to provide courses and individual training for 200 participants to learn in depth, for others to train themselves using our models and tutorials on the web, and for any investigator to take these published models as starting points for their own models. The result should enhance our nation's capabilities in quantitative research analysis and improve our competitiveness in the advancement of diagnostic and therapeutic techniques.

描述（由申请人提供）： 该应用程序是根据 RFA-HL-07-002 编写的，题为“心脏、肺和血液建模：从细胞到器官”，旨在本着 Physiome 努力的精神为研究人员提供计算建模培训，其目标是开发定量生物学以改善从基因到健康的医学科学。该计划将包括每年 2 门课程、会议研讨会、网络教程和建模、免费分发的模型程序和建模系统库以及个人学员后续培训计划。中心任务是帮助研究人员发展有效实验研究设计和使用综合生理模型分析数据的专业知识。这些课程的重点是应用科学方法的原理来设计和检验假设，以及使用参数化和观察分类来进行诊断和治疗。涵盖范围从细胞和亚细胞系统的生物物理和生化水平模块的开发，到心血管、呼吸和血液系统的全身综合系统。通过从课程第一个小时开始使用 JSim 进行动手建模，JSim 是一个功能强大但易于学习的模拟系统，处理常微分方程和偏微分方程（ODE 和 PDE）、随机模型等，参与者将学习如何检查数据以提出假设，如何将想法转化为数学可检验的模型假设，如何评估计算机解决方案的真实性和准确性，如何使用建模设计关键实验，如何通过优化来分析数据 提供参数残差和置信范围的技术，以及如何评估假设的有效性并迭代假设-模型-实验-验证循环。课程参与者将使用 JSim（独立于平台的仿真分析系统）和 Matlab 等软件。他们将学习适合求解 ODE、Gepasi、XPPAUT 等的仿真系统以及其他工具，例如系统生物学工作台。参与者还可以选择返回进行个人培训或合作研究。每年六月的课程将强调基本的生物物理、生理和生化模块设计和构建，以及使用正电子发射断层扫描或磁共振综合模型应用于临床研究。每年九月的课程都会强调一个应用领域，例如心脏或呼吸研究。在为期 4 年的计划中，我们计划为 200 名参与者提供课程和个人培训，让他们深入学习，让其他人使用我们的模型和网络教程进行自我培训，并让任何研究人员将这些已发布的模型作为他们自己模型的起点。研究结果将增强我国定量研究分析能力，提高诊断和治疗技术进步的竞争力。