Modeling for Heart, Lung, and Blood: From Cell to Organ

心脏、肺和血液建模：从细胞到器官

• 批准号: 7391153
• 负责人: JAMES B BASSINGTHWAIGHTE
• 金额: $ 23.22万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391153
• 关键词: Actins; Action Potentials; Address; Aerosols; Alveolar; Alveolus; Anatomic Models; Anatomy; Appendix; Archives; Area; Asthma; Basic Science; Behavior; Binding; Biochemical; Biochemical Pathway; Biological; Biological Models; Biology; Biomedical Engineering; Blood; Blood Cells; Blood Vessels; Blood capillaries; Bolus Infusion; Breathing; Carbon Dioxide; Cardiac; Cardiovascular Models; Cardiovascular Physiology; Cardiovascular system; Cell model; Cells; Cellular biology; Chest wall structure; Chronic Obstructive Airway Disease; Clinical; Clinical Research; Code; Coffee; Collaborations; Commit; Complex; Computer Simulation; Computer Systems; Computer software; Computers; Condition; Conflict (Psychology); Consumption; Convection; Critiques; Data; Data Analyses; Data Set; Databases; Decision Making; Dependence; Depth; Development; Diagnosis; Diagnostic; Diffuse; Diffusion; Dimensions; Disease; Drug Delivery Systems; Educational process of instructing; Educational workshop; Elasticity; Electronic Mail; Electrophysiology (science); Environment; Environmental air flow; Equation; Equilibrium; Evaluation; Exclusion; Excretory function; Exercise; Exhalation; Facility Construction Funding Category; Faculty; Familiarity; Feedback; Finite Element Analysis; Gases; Generations; Genes; Genetic; Genome; Goals; Grant; Graph; Hand; Health; Hearing; Heart; Hemoglobin; Heterogeneity; Hodgkin Disease; Hour; Image; Imagery; Imaging Techniques; Indicator Dilution Techniques; Individual; Internet; Investigation; Ion Channel; Kidney; Kinetics; Knowledge; Laboratories; Language; Learning; Letters; Libraries; Life; Liquid substance; Literature; Lung; Lung Compliance; Magnetic Resonance; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Meat; Mechanics; Medical; Membrane; Membrane Potentials; Metabolic; Metabolic Diseases; Metabolism; Methods; Mission; Modeling; Molecular Conformation; Monitor; Mucous body substance; Myocardial Infarction; Myocardial perfusion; Myocardium; Myosin ATPase; Na(+)-K(+)-Exchanging ATPase; Nerve; Nitric Oxide; Noble Gases; Numbers; Occupational Exposure; Organ; Oxygen; Ozone; Paper; Partial Liquid Ventilation; Participant; Perfusion; Physics; Physiological; Physiology; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Predictive Value; Preparation; Pressoreceptors; Principal Investigator; Procedures; Process; Program Evaluation; Programming Languages; Proteins; Publications; Publishing; Pulmonary Circulation; Pulmonary Pathology; Pulmonary alveolar structure; Pump; Range; Rate; Reaction; Relative (related person); Research; Research Personnel; Residual state; Resistance; Respiratory System; Running; Sarcomeres; Schedule; Science; Score; Self Assessment; Semantics; Series; Signal Transduction; Simulate; Site; Solid; Solutions; Source; Standards of Weights and Measures; Stress; Structure; Students; Support of Research; Surveys; System; Systems Analysis; Systems Biology; Techniques; Testing; Text; Therapeutic; Time; Tissues; Training; Training Programs; Translating; Transport Reaction; Tube; Validation; Variant; Visit; Vital capacity; Vocabulary; Week; Wireless Technology; Work; Writing; analog; base; capillary; chemical reaction; clinical application; computerized tools; concept; cost; data acquisition; data modeling; day; design; design and construction; desire; discount; experience; follow-up; improved; instructor; lecturer; lectures; mathematical model; model development; multi-scale modeling; passive transport; phosphoric diester hydrolase; platform-independent; pressure; programs; receptor density; research and development; research study; respiratory; response; simulation; single photon emission computed tomography; solute; surfactant; symposium; theories; tool; uptake; voltage

DESCRIPTION (provided by applicant): This application, written in response to RFA-HL-07-002, entitled Modeling for Heart, Lung, and Blood: From Cell to Organ, is to provide training in computational modeling for investigators in the spirit of the Physiome effort, which has the goal of developing quantitative biology to improve medical science from genes to health. The program will consist of 2 courses per year, workshops at meetings, web tutorials and modeling, libraries of model programs and modeling systems for free distribution, and individual trainee follow-up training programs. The central mission is to aid investigators in developing expertise in the design of efficient experimental studies and in the analysis of data using integrative physiological models. The courses focus on applying the principles of the scientific method for designing and testing hypotheses and the use of parameterization and categorization of observations for diagnosis and therapy. The coverage ranges from the development of biophysical and biochemical level modules for cellular and subcellular systems, to whole body integrative systems for cardiovascular, respiratory and hematologic systems. Via hands on modeling from the first hour of the course using JSim a powerful but easily learned simulation system handling ordinary and partial differential equations (ODE and PDEs), stochastic models, etc., participants will learn how to examine data in order to develop hypotheses, how to convert ideas into mathematical testable model-hypotheses, how to evaluate the veracity and accuracy of computer solutions, how to design critical experiments using modeling, how to analyze data by optimization techniques providing residuals and confidence ranges for parameters, and how to evaluate validity of hypotheses and iterate the hypothesis-model- experiment-validation loop. Course participants will use software such as JSim, a platform-independent simulation analysis system, and Matlab. They will learn about simulation systems suitable for solving ODEs, Gepasi, XPPAUT, etc. and other tools, e.g. Systems Biology Workbench. Participants may also choose to return for individual training or for collaborative research. Each year the June course will emphasize elemental biophysical, physiological, and biochemical module design and construction, with application to clinical research using integrative models for positron emission tomography or magnetic resonance. Each year the September course will emphasize an application area such as cardiac or respiratory studies. Over the 4-year program we plan to provide courses and individual training for 200 participants to learn in depth, for others to train themselves using our models and tutorials on the web, and for any investigator to take these published models as starting points for their own models. The result should enhance our nation's capabilities in quantitative research analysis and improve our competitiveness in the advancement of diagnostic and therapeutic techniques.

描述（由申请人提供）： 该应用程序是响应RFA-HL-07-002编写的，标题为“心脏，肺和血液建模：从细胞到器官”，旨在为Physiome努力的研究人员提供计算建模方面的培训，其目标是开发定量生物学，以改善从基因到健康的医学科学。该计划将包括每年2门课程、会议研讨会、网络教程和建模、免费分发的模型程序和建模系统库以及个人学员后续培训计划。中心使命是帮助研究者发展设计有效实验研究和使用综合生理模型分析数据的专业知识。这些课程侧重于应用科学方法的原则来设计和检验假设，以及使用参数化和分类观察诊断和治疗。覆盖范围从细胞和亚细胞系统的生物物理和生物化学水平模块的发展，到心血管，呼吸和血液系统的全身综合系统。通过从课程的第一个小时开始使用JSim进行建模，JSim是一个功能强大但易于学习的模拟系统，可处理常微分方程和偏微分方程（ODE和PDE），随机模型等，参与者将学习如何检查数据以提出假设，如何将想法转换为可测试的数学模型假设，如何评估计算机解决方案的真实性和准确性，如何使用建模设计关键实验，如何通过优化技术分析数据提供参数的残差和置信范围，以及如何评价假设的有效性和构建假设-模型-实验-验证的循环。课程参与者将使用软件，如JSim，一个平台无关的仿真分析系统，和Matlab。他们将学习适用于求解ODE，Gepasi，XPPAUT等的模拟系统以及其他工具，例如系统生物学工具。参加者也可以选择返回参加个人培训或合作研究。每年6月的课程将强调元素生物物理，生理和生化模块的设计和建设，与应用到临床研究使用正电子发射断层扫描或磁共振的综合模型。每年9月的课程将强调一个应用领域，如心脏或呼吸研究。在为期4年的计划中，我们计划为200名参与者提供课程和个人培训，让他们深入学习，让其他人使用我们的模型和网络教程进行培训，并让任何研究人员将这些已发布的模型作为自己模型的起点。这一成果将提高我国在定量研究分析方面的能力，并提高我国在诊断和治疗技术进步方面的竞争力。