Novel Functional Nanocomposite Engineering of Stents

新型功能性纳米复合材料支架工程

• 批准号: EP/D064945/1
• 负责人: Jian Lu
• 金额: $ 31.79万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD064945%2F1
• 关键词: Novel; Functional; Nanocomposite; Engineering; Stents

We propose a four-party collaborative research programme that combines the expertise of the materials science, engineering, and surface science and cell biology from four leading universities. We wish to continue our highly successful Flagship Grant programme in the development of Abdominal Aortic Aneurysm (AAA) stent graft and coronary stent whereby stainless steel and shape memory alloy (SMA) are coated with nanocomposite (NC) polymer. Our preliminary work has demonstrated excellent blood and tissue biocompatibility and we have attributed this property to the preferential adsorption of fibrinogen followed by its conformational deactivation. Further work is required for mechanical and haemodynamic testing in vitro and in vivo. We intend to complete the deployment and positioning studies to allow an animal study to take place, leading to commercialisation. To achieve these aims we will use a novel packaging technique to fold the stent into a small and uniform diameter avoiding geometric incompatibility. The folding is achieved by generating a set of folds onto the surface of a graft using origami-based techniques. We will make the graft from either SMA with NC coated or entirely from a radio-opaque SMNC. Coating will be achieved using electrohydrodynamic spray deposition (ESD). Spectroscopic ellipsometry (SE) and neutron reflection (NR) will be utilised to determine how durable these materials are in vitro and how they achieve biocompatibility. Successful delivery of the programme will lead to the development of a stent that has significant advantages over existing devices including geometric simplicity, a more reliable expansion mechanism, higher radial strength, the ability to shape the structure to the artery, and better biocompatibility with both blood and tissue. With engineering, materials, surface science and biological groups in close collaboration, structural design and novel manufacturing concepts can be applied to new materials development and stent fabrication, simplifying the regulatory pathway and acceptance to the marketplace. The proposal is highly likely to succeed as it has a unique integrated structure and approach. All the applicants have international reputations in their own fields, have established records in integrated adventurous projects and have recognised track records for commercialising concepts and products and as a team are well suited for carrying out the proposed research.

我们提出了一个四方合作研究计划，结合了四所领先大学的材料科学，工程，表面科学和细胞生物学的专业知识。我们希望继续我们在腹主动脉瘤（AAA）支架移植物和冠状动脉支架开发方面非常成功的旗舰资助项目，其中不锈钢和形状记忆合金（SMA）涂有纳米复合材料（NC）聚合物。我们的初步工作已经证明了良好的血液和组织的生物相容性，我们已经归因于这种属性的纤维蛋白原的优先吸附，其次是其构象失活。需要进一步的工作，在体外和体内的机械和血液动力学测试。我们打算完成部署和定位研究，以便进行动物研究，从而实现商业化。为了实现这些目标，我们将使用一种新型包装技术将支架折叠成小而均匀的直径，避免几何不相容性。通过使用基于折纸的技术在移植物的表面上产生一组折叠来实现折叠。我们将使用带NC涂层的SMA或完全使用不透射线的SMNC制作移植物。将使用电流体动力学喷涂沉积（ESD）实现涂层。光谱椭圆偏振法（SE）和中子反射（NR）将用于确定这些材料在体外的耐用性以及它们如何实现生物相容性。该项目的成功实施将导致开发出一种支架，该支架与现有器械相比具有显著优势，包括几何简单性、更可靠的扩张机制、更高的径向强度、使结构符合动脉的能力以及与血液和组织更好的生物相容性。通过工程、材料、表面科学和生物学小组的密切合作，结构设计和新的制造概念可以应用于新材料开发和支架制造，简化监管途径和市场接受度。该提案极有可能获得成功，因为它具有独特的综合结构和方法。所有申请人都在自己的领域享有国际声誉，在综合冒险项目中建立了记录，并在商业化概念和产品方面有公认的记录，作为一个团队非常适合开展拟议的研究。