Stereokinetics / the optimisation of catalytic asymmetric reactions

立体动力学/催化不对称反应的优化

基本信息

  • 批准号:
    EP/D072182/1
  • 负责人:
  • 金额:
    $ 69.47万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

Many useful chemical substances are made of molecules that can exist in two forms which differ only in that the arrangement of their atoms are mirror images, very much like the arrangement of fingers and thumbs on left and right hands. These mirror image molecules can also be described as left-hand and right-hand versions. These mirror image molecules generally behave the same way in many chemical reactions, but when interacting with living systems they often behave very differently because the living systems are also made up of mirror image molecules. As in the shaking of hands, a right-hand to right-hand contact is very different to a right-hand to left-hand contact. Therefore if we are to make medicines to cure disease one of the properties must be whether it includes a left-hand or right-hand version of a molecule. We need to be able to decide which version will make the best medicine, and then work out a way of making it without making the other one at the same time. In our project we are working on this second problem. In our chemical reactions we are giving molecules the opportunity to become left or right hand versions. Like cars stopping at a T-junction, they can turn either left or right. We are interested in making a molecular traffic policeman that will stand at the junction and direct the flow of molecules only one way, either left or right as we decide. The policeman molecule has to be able to signal strongly enough, and fast enough to keep up with the flow of molecular traffic. Of course it should be possible to put a policeman in every car; we wouldn't have to get the signal timing right, but it would be rather expensive in policemen, so our way is better. If we can make better (and faster!) signalling policeman molecules we can make more of the mirror image molecules we want and fewer of the ones we don't. The research proposed here will revolutionalise the way new asymmetric catalysts (policeman molecules) can be developed by providing a simple method for direct comparison.These better and cleaner methods for controlling chemical reactions will result in the cheaper and more environmentally manufacture of chemicals, particularly on the large scales used by the chemical and pharmaceutical industries. This would be very useful for people making new medicines.
许多有用的化学物质是由分子构成的,这些分子可以以两种形式存在,不同之处在于它们的原子排列是镜像,很像左手和右手的手指和拇指的排列。这些镜像分子也可以被描述为左手和右手两个版本。这些镜像分子通常在许多化学反应中表现相同,但当与生命系统相互作用时,它们的行为往往非常不同,因为生命系统也是由镜像分子组成的。就像握手一样,右手对右手的接触与右手对左手的接触是非常不同的。因此,如果我们要制造治疗疾病的药物,其中一个性质必须是它是否包含一个分子的左手或右手版本。我们需要能够决定哪一种版本是最好的药物,然后找出一种不同时制造另一种版本的方法。在我们的项目中,我们正在研究第二个问题。在我们的化学反应中,我们给了分子变成左旋或右旋的机会。就像汽车停在t形路口一样,它们可以左转也可以右转。我们感兴趣的是制造一个分子交通警察,它将站在十字路口,指挥分子只向一个方向流动,由我们决定向左或向右。警察分子必须能够发出足够强、足够快的信号,以跟上分子交通的流动。当然,每辆车里都应该有一名警察;我们不需要把信号定时弄对,但是对警察来说会很昂贵,所以我们的方法更好。如果我们能制造出更好(更快!)的信号警察分子,我们就能制造出更多我们想要的镜像分子,减少我们不想要的镜像分子。这里提出的研究将通过提供一种简单的直接比较方法,彻底改变新的不对称催化剂(警察分子)的开发方式。这些更好和更清洁的控制化学反应的方法将导致更便宜和更环保的化学品制造,特别是在化学和制药工业大规模使用的情况下。这将对人们制造新药非常有用。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David Fox其他文献

A Healthcare Utilization Model Comparing Time Toxicity between Glofitamab and Epcoritamab
  • DOI:
    10.1182/blood-2024-198476
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Pallawi Torka;Anthony Masaquel;Lourenia Cassoli;David Fox;Arliene Mangalindan;Ajay Major
  • 通讯作者:
    Ajay Major
EXACT SOLUTIONS OF CYCLICALLY SYMMETRIC OSCILLATOR EQUATIONS WITH NON‐LINEAR COUPLING. PART III: GLOBALLY STABLE SINGLE‐FREQUENCY LIMIT CYCLES
非线性耦合循环对称振荡器方程的精确解第 III 部分:全局稳定单频极限循环。
  • DOI:
    10.1002/(sici)1097-007x(199705/06)25:3<199::aid-cta963>3.0.co;2-g
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Fox
  • 通讯作者:
    David Fox
Otologic assessment of blast and nonblast injury in returning middle east‐deployed service members
回国中东部署军人爆炸性和非爆炸性损伤的耳科评估
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anil N. Shah;M. Ayala;G. Capra;David Fox;M. Hoffer
  • 通讯作者:
    M. Hoffer
Enabling machine learning-ready HPC ensembles with Merlin
使用 Merlin 实现机器学习就绪的 HPC 集成
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. L. Peterson;B. Bay;Joseph Koning;Peter B. Robinson;Jessica Semler;Jeremy White;Rushil Anirudh;Kevin Athey;P. Bremer;F. Natale;David Fox;J. Gaffney;S. A. Jacobs;B. Kailkhura;B. Kustowski;S. Langer;B. Spears;J. Thiagarajan;B. V. Essen;Jae
  • 通讯作者:
    Jae
Settlement patterns and their potential implications for livelihoods among Maasai pastoralists in northern Tanzania
坦桑尼亚北部马赛牧民的定居模式及其对生计的潜在影响
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Fox
  • 通讯作者:
    David Fox

David Fox的其他文献

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{{ truncateString('David Fox', 18)}}的其他基金

Collaborative Research: EVOLUTION OF NORTH AMERICAN SMALL MAMMAL COMMUNITIES IN RESPONSE TO OLIGO-MIOCENE LANDSCAPE CHANGE
合作研究:北美小哺乳动物群落响应寡中新世景观变化的进化
  • 批准号:
    2322805
  • 财政年份:
    2023
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
ELT Collaborative research: Evolutionary and ecological responses of small mammal communities to habitat and climate change over the last 5 million years
ELT 合作研究:过去 500 万年小型哺乳动物群落对栖息地和气候变化的进化和生态反应
  • 批准号:
    1338262
  • 财政年份:
    2013
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Collaborative Research: Quaternary Archaeology and Environments of Rusinga and Mfangano Islands, Kenya
合作研究:肯尼亚鲁辛加和姆凡加诺群岛第四纪考古学和环境
  • 批准号:
    1013134
  • 财政年份:
    2010
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Collaborative research: Paleobiology and exinction of mammoths in northern Siberia and Wrangel Island
合作研究:西伯利亚北部和弗兰格尔岛的古生物学和猛犸象灭绝
  • 批准号:
    0545090
  • 财政年份:
    2006
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Evolution of Marine Mammal Foraging Behavior Based on Ca and C Isotope Ratios in Bioapatite
基于生物磷灰石中 Ca 和 C 同位素比率的海洋哺乳动物觅食行为的演变
  • 批准号:
    0519052
  • 财政年份:
    2005
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
COLLABORATIVE RESEARCH: Plio-Pleistocene Mammal Faunas and Environmental Change in the Meade Basin of Southwestern Kansas: A Combined Stratigraphic, Faunal, and Isotopic Approach
合作研究:堪萨斯州西南部米德盆地的上更新世哺乳动物区系和环境变化:地层学、动物区系和同位素相结合的方法
  • 批准号:
    0207383
  • 财政年份:
    2002
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Stable Carbon Isotope Variation in Late Miocene Paleosol Carbonates from North America: Habitat Change and Mammalian Evolution
北美晚中新世古土壤碳酸盐的稳定碳同位素变化:栖息地变化和哺乳动物进化
  • 批准号:
    9901693
  • 财政年份:
    1999
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Mathematical Sciences: High Speed Methods for Algebraic Eigenvalue Problems using Intermediate Problem Techniques
数学科学:使用中间问题技术解决代数特征值问题的高速方法
  • 批准号:
    8807483
  • 财政年份:
    1988
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Student Science Training Program
学生科学训练计划
  • 批准号:
    8024997
  • 财政年份:
    1981
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant

相似海外基金

Reactor design and performance optimisation for catalytic hydrogen production from methane
甲烷催化制氢反应器设计和性能优化
  • 批准号:
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  • 财政年份:
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IN-SITU CATALYTIC UPGRADING OF HEAVY CRUDE AND BITUMEN: OPTIMISATION OF NOVEL CAPRI REACTOR
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  • 批准号:
    EP/E057977/1
  • 财政年份:
    2007
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    $ 69.47万
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Optimisation of catalytic combustion systems
催化燃烧系统的优化
  • 批准号:
    6825-2003
  • 财政年份:
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Optimisation and control of catalytic reactors for GHG reduction
温室气体减排催化反应器的优化和控制
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    NSERC/Energy Sector, Natural Resources Canada
Optimisation of catalytic combustion systems
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温室气体减排催化反应器的优化和控制
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温室气体减排催化反应器的优化和控制
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    NSERC/Energy Sector, Natural Resources Canada
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催化燃烧系统的优化
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