Stereokinetics / the optimisation of catalytic asymmetric reactions

立体动力学/催化不对称反应的优化

基本信息

  • 批准号:
    EP/D072182/1
  • 负责人:
  • 金额:
    $ 69.47万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

Many useful chemical substances are made of molecules that can exist in two forms which differ only in that the arrangement of their atoms are mirror images, very much like the arrangement of fingers and thumbs on left and right hands. These mirror image molecules can also be described as left-hand and right-hand versions. These mirror image molecules generally behave the same way in many chemical reactions, but when interacting with living systems they often behave very differently because the living systems are also made up of mirror image molecules. As in the shaking of hands, a right-hand to right-hand contact is very different to a right-hand to left-hand contact. Therefore if we are to make medicines to cure disease one of the properties must be whether it includes a left-hand or right-hand version of a molecule. We need to be able to decide which version will make the best medicine, and then work out a way of making it without making the other one at the same time. In our project we are working on this second problem. In our chemical reactions we are giving molecules the opportunity to become left or right hand versions. Like cars stopping at a T-junction, they can turn either left or right. We are interested in making a molecular traffic policeman that will stand at the junction and direct the flow of molecules only one way, either left or right as we decide. The policeman molecule has to be able to signal strongly enough, and fast enough to keep up with the flow of molecular traffic. Of course it should be possible to put a policeman in every car; we wouldn't have to get the signal timing right, but it would be rather expensive in policemen, so our way is better. If we can make better (and faster!) signalling policeman molecules we can make more of the mirror image molecules we want and fewer of the ones we don't. The research proposed here will revolutionalise the way new asymmetric catalysts (policeman molecules) can be developed by providing a simple method for direct comparison.These better and cleaner methods for controlling chemical reactions will result in the cheaper and more environmentally manufacture of chemicals, particularly on the large scales used by the chemical and pharmaceutical industries. This would be very useful for people making new medicines.
许多有用的化学物质是由分子组成的,它们可以以两种形式存在,不同之处仅在于它们的原子排列是镜像,非常像左手和右手的手指和拇指的排列。这些镜像分子也可以被描述为左手和右手版本。这些镜像分子通常在许多化学反应中表现相同的方式,但当与生命系统相互作用时,它们的表现往往非常不同,因为生命系统也由镜像分子组成。就像握手一样,右手与右手的接触与右手与左手的接触是非常不同的。因此,如果我们要制造治疗疾病的药物,其中一个性质必须是它是否包含左旋或右旋分子。我们需要能够决定哪种版本将成为最好的药物,然后找到一种方法来制造它,而不同时制造另一种。在我们的项目中,我们正在解决第二个问题。在我们的化学反应中,我们让分子有机会变成左手型或右手型。就像停在丁字路口的汽车一样,它们可以左转也可以右转。我们感兴趣的是制造一个分子交通警察,它将站在交叉口,只向一个方向引导分子的流动,由我们决定是向左还是向右。警察分子必须能够发出足够强的信号,并且足够快,以跟上分子交通的流动。当然,在每辆车里都安排一个警察是可能的;我们不必把信号灯的时间安排得很好,但是警察的费用相当高,所以我们的方法更好。如果我们能做得更好(更快!)我们可以制造更多我们想要的镜像分子,而更少我们不想要的镜像分子。本文提出的研究将通过提供一种简单的直接比较方法,彻底改变新的不对称催化剂(警察分子)的开发方式。这些更好、更清洁的控制化学反应的方法将导致更便宜、更环保的化学品生产,特别是在化学和制药工业的大规模生产中。这对研制新药的人非常有用。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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David Fox其他文献

A Healthcare Utilization Model Comparing Time Toxicity between Glofitamab and Epcoritamab
  • DOI:
    10.1182/blood-2024-198476
  • 发表时间:
    2024-11-05
  • 期刊:
  • 影响因子:
  • 作者:
    Pallawi Torka;Anthony Masaquel;Lourenia Cassoli;David Fox;Arliene Mangalindan;Ajay Major
  • 通讯作者:
    Ajay Major
EXACT SOLUTIONS OF CYCLICALLY SYMMETRIC OSCILLATOR EQUATIONS WITH NON‐LINEAR COUPLING. PART III: GLOBALLY STABLE SINGLE‐FREQUENCY LIMIT CYCLES
非线性耦合循环对称振荡器方程的精确解第 III 部分:全局稳定单频极限循环。
  • DOI:
    10.1002/(sici)1097-007x(199705/06)25:3<199::aid-cta963>3.0.co;2-g
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Fox
  • 通讯作者:
    David Fox
Otologic assessment of blast and nonblast injury in returning middle east‐deployed service members
回国中东部署军人爆炸性和非爆炸性损伤的耳科评估
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anil N. Shah;M. Ayala;G. Capra;David Fox;M. Hoffer
  • 通讯作者:
    M. Hoffer
Enabling machine learning-ready HPC ensembles with Merlin
使用 Merlin 实现机器学习就绪的 HPC 集成
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. L. Peterson;B. Bay;Joseph Koning;Peter B. Robinson;Jessica Semler;Jeremy White;Rushil Anirudh;Kevin Athey;P. Bremer;F. Natale;David Fox;J. Gaffney;S. A. Jacobs;B. Kailkhura;B. Kustowski;S. Langer;B. Spears;J. Thiagarajan;B. V. Essen;Jae
  • 通讯作者:
    Jae
Settlement patterns and their potential implications for livelihoods among Maasai pastoralists in northern Tanzania
坦桑尼亚北部马赛牧民的定居模式及其对生计的潜在影响
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Fox
  • 通讯作者:
    David Fox

David Fox的其他文献

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{{ truncateString('David Fox', 18)}}的其他基金

Collaborative Research: EVOLUTION OF NORTH AMERICAN SMALL MAMMAL COMMUNITIES IN RESPONSE TO OLIGO-MIOCENE LANDSCAPE CHANGE
合作研究:北美小哺乳动物群落响应寡中新世景观变化的进化
  • 批准号:
    2322805
  • 财政年份:
    2023
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
ELT Collaborative research: Evolutionary and ecological responses of small mammal communities to habitat and climate change over the last 5 million years
ELT 合作研究:过去 500 万年小型哺乳动物群落对栖息地和气候变化的进化和生态反应
  • 批准号:
    1338262
  • 财政年份:
    2013
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Collaborative Research: Quaternary Archaeology and Environments of Rusinga and Mfangano Islands, Kenya
合作研究:肯尼亚鲁辛加和姆凡加诺群岛第四纪考古学和环境
  • 批准号:
    1013134
  • 财政年份:
    2010
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Collaborative research: Paleobiology and exinction of mammoths in northern Siberia and Wrangel Island
合作研究:西伯利亚北部和弗兰格尔岛的古生物学和猛犸象灭绝
  • 批准号:
    0545090
  • 财政年份:
    2006
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Evolution of Marine Mammal Foraging Behavior Based on Ca and C Isotope Ratios in Bioapatite
基于生物磷灰石中 Ca 和 C 同位素比率的海洋哺乳动物觅食行为的演变
  • 批准号:
    0519052
  • 财政年份:
    2005
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
COLLABORATIVE RESEARCH: Plio-Pleistocene Mammal Faunas and Environmental Change in the Meade Basin of Southwestern Kansas: A Combined Stratigraphic, Faunal, and Isotopic Approach
合作研究:堪萨斯州西南部米德盆地的上更新世哺乳动物区系和环境变化:地层学、动物区系和同位素相结合的方法
  • 批准号:
    0207383
  • 财政年份:
    2002
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Stable Carbon Isotope Variation in Late Miocene Paleosol Carbonates from North America: Habitat Change and Mammalian Evolution
北美晚中新世古土壤碳酸盐的稳定碳同位素变化:栖息地变化和哺乳动物进化
  • 批准号:
    9901693
  • 财政年份:
    1999
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant
Mathematical Sciences: High Speed Methods for Algebraic Eigenvalue Problems using Intermediate Problem Techniques
数学科学:使用中间问题技术解决代数特征值问题的高速方法
  • 批准号:
    8807483
  • 财政年份:
    1988
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Continuing Grant
Student Science Training Program
学生科学训练计划
  • 批准号:
    8024997
  • 财政年份:
    1981
  • 资助金额:
    $ 69.47万
  • 项目类别:
    Standard Grant

相似海外基金

Reactor design and performance optimisation for catalytic hydrogen production from methane
甲烷催化制氢反应器设计和性能优化
  • 批准号:
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  • 财政年份:
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IN-SITU CATALYTIC UPGRADING OF HEAVY CRUDE AND BITUMEN: OPTIMISATION OF NOVEL CAPRI REACTOR
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IN-SITU CATALYTIC UPGRADING OF HEAVY CRUDE AND BITUMEN: OPTIMISATION OF NOVEL CAPRI REACTOR
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  • 批准号:
    EP/E057977/1
  • 财政年份:
    2007
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    $ 69.47万
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Optimisation of catalytic combustion systems
催化燃烧系统的优化
  • 批准号:
    6825-2003
  • 财政年份:
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Optimisation and control of catalytic reactors for GHG reduction
温室气体减排催化反应器的优化和控制
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    NSERC/Energy Sector, Natural Resources Canada
Optimisation of catalytic combustion systems
催化燃烧系统的优化
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温室气体减排催化反应器的优化和控制
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温室气体减排催化反应器的优化和控制
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    $ 69.47万
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    NSERC/Energy Sector, Natural Resources Canada
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催化燃烧系统的优化
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