Developing theory on the formation, composition and structure of open microbial communities that can be used in engineering design

发展可用于工程设计的开放微生物群落的形成、组成和结构理论

• 批准号: EP/D073693/1
• 负责人: William Sloan
• 金额: $ 66.07万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD073693%2F1
• 关键词: Developing; theory; formation; composition; structure

Large multi-species communities of microbes are exploited in a wide range of long-established and newly emerging technologies, such as wastewater treatment, bioremediation and electricity generation from wastewater using microbial fuel cells. However, the coming together, or assembly, of large communities in natural environments and the fluctuations in their composition and structure, once assembled, is still poorly understood. The remarkable success of some of the more established technologies, such as wastewater treatment, can largely be attributed to the wealth of empirical knowledge that has been built up through many years of research and application. However, such a climate of empirically based technological evolution, makes difficult the translation of any insights from similar strategies in different environments. Furthermore, industry's adoption of new technologies is slowed by our inability to quantify both the common and key processes in microbial community assembly and the relationships between community composition, structure and function. Therefore, satisfactory mathematical descriptions of the microbial world are now the bottleneck in successfully engineering microbiological systems. A theoretical basis for predicting and manipulating microbial community composition and structure will have a wide application: setting established practices on a new theoretical foundation; quantifying the risk in emerging environmental biotechnologies; and potentially opening up whole new technologies. The research proposed in this Advanced Fellowship application aims to build upon previous successes in modelling microbial community assembly and develop further quantitative, testable theories for the microbiology of biological waste treatment systems.

大型多物种微生物群落被用于广泛的历史悠久和新兴技术，如废水处理、生物修复和使用微生物燃料电池从废水中发电。然而，人们对自然环境中大型群落的聚集或集合，以及一旦集合后其组成和结构的波动，仍然知之甚少。一些较为成熟的技术，如废水处理，之所以取得显著成功，主要是因为通过多年的研究和应用积累了丰富的经验知识。然而，这种基于经验的技术进化的气候，使得难以从不同环境中的类似战略中翻译任何见解。此外，由于我们无法量化微生物群落组装中的常见和关键过程以及群落组成、结构和功能之间的关系，工业对新技术的采用速度减慢。因此，令人满意的数学描述的微生物世界，现在成功地工程微生物系统的瓶颈。预测和操纵微生物群落组成和结构的理论基础将有广泛的应用：在新的理论基础上建立既定的实践;量化新兴环境生物技术的风险;并可能开辟全新的技术。这项高级奖学金申请中提出的研究旨在建立在以前成功模拟微生物群落组装的基础上，并为生物废物处理系统的微生物学开发进一步的定量，可测试的理论。

项目成果

Microbial community assembly, theory and rare functions.

• DOI: 10.3389/fmicb.2013.00068
• 发表时间: 2013
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Pholchan MK;Baptista Jde C;Davenport RJ;Sloan WT;Curtis TP
• 通讯作者: Curtis TP

Headwaters are critical reservoirs of microbial diversity for fluvial networks.

• DOI: 10.1098/rspb.2013.1760
• 发表时间: 2013-11-22
• 期刊: Proceedings. Biological sciences
• 作者: Besemer K;Singer G;Quince C;Bertuzzo E;Sloan W;Battin TJ
• 通讯作者: Battin TJ

Probabilistic models to describe the dynamics of migrating microbial communities.

• DOI: 10.1371/journal.pone.0117221
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Schroeder JL;Lunn M;Pinto AJ;Raskin L;Sloan WT
• 通讯作者: Sloan WT

Spatial-temporal survey and occupancy-abundance modeling to predict bacterial community dynamics in the drinking water microbiome.

• DOI: 10.1128/mbio.01135-14
• 发表时间: 2014-05-27
• 期刊: mBio
• 影响因子: 6.4
• 作者: Pinto AJ;Schroeder J;Lunn M;Sloan W;Raskin L
• 通讯作者: Raskin L