Hot Flashes and Anxiety Sensitivity Among Breast Cancer Survivors

乳腺癌幸存者的潮热和焦虑敏感性

• 批准号: 7337184
• 负责人: LAURA J. HANISCH
• 金额: $ 7.88万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-12 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7337184
• 关键词: Accounting; Affect; Anxiety; Arousal; Behavioral; Biological; Body Temperature; Cancer Survivor; Clinical; Clinical Trials; Cognitive; Cognitive Therapy; Daily; Detection; Development; Dimensions; Distress; Electric Conductivity; Esthesia; Feeling; Frequencies; Fright; Frustration; General Population; Goals; Gold; Happiness; Health; Heating; Hormones; Hot flushes; Individual; Individual Differences; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Measures; Medical; Menopausal hot flushes; Menopause; Methods; Modeling; Monitor; Nature; Outcome; Patient Self-Report; Physiologic Thermoregulation; Physiological; Pilot Projects; Production; Quality of life; Questionnaires; Rate; Recruitment Activity; Relaxation; Reporting; Research; Risk; Sampling; Self Management; Severities; Signal Transduction; Skin; Standards of Weights and Measures; Stimulus; Sweat; Sweat Glands; Sweating; Symptoms; Techniques; Testing; Time; Woman; base; design; diaries; experience; malignant breast neoplasm; novel; psychologic; response

DESCRIPTION (provided by applicant): Among breast cancer survivors, hot flashes are prevalent and have an intensity and intrusiveness that exceeds levels among healthy women. Hot flashes, especially when severe, negatively affect the quality of life of breast cancer survivors. Preliminary evidence suggests that in menopausal women, greater anxiety is associated with more severe and frequent hot flashes, but anxiety is also associated with discrepancies between reported and objectively recorded hot flashes. Understanding the underlying psychological and biological mechanisms of hot flashes is essential to finding treatments which are acceptable and effective for breast cancer survivors. This pilot project will further assess the relationship between psychological variables and hot flashes by evaluating a model in which anxiety sensitivity, the fear of arousal symptoms, is a key individual difference variable contributing to reports of the occurrence and severity of hot flashes among breast cancer survivors. Samples of breast cancer survivors will be recruited, provided with a packet of questionnaires and a daily diary, and fitted with a Biolog monitor to record sternal skin conductance, the current gold standard for assessing objective hot flashes. Chart abstractions will be used to obtain clinical information. The overarching goal is not only to understand the psychological dimensions of the production and experience of hot flashes, but to provide a rationale for specific, new management strategies. This model provides a basis for identifying individuals most at risk for disturbing hot flashes, and can serve as a basis for developing novel, cognitive-behavioral interventions for hot flashes. Additionally, findings of individual differences in discrepancies between reported and objectively recorded hot flash will have broader implications for the design and interpretation of clinical trials testing medical treatments. Besides breast cancer survivors, results will have implications for hot flashes experienced by prostate cancer survivors and the general population of women, the majority of whom also at some point experience hot flashes. Furthermore, the results of this study may have implications for the management of other forms of cancer-related symptom distress. This project examines why some women being treated for breast cancer experience more intense and frequent hot flashes than by healthy women during natural menopause. The goal is to develop better strategies for the self-management of hot flashes using cognitive-behavioral techniques.

描述（由申请人提供）：在乳腺癌幸存者中，潮热很普遍，并且其强度和侵入性超过了健康女性的水平。潮热，尤其是严重时，会对乳腺癌幸存者的生活质量产生负面影响。初步证据表明，在更年期女性中，更大的焦虑与更严重和更频繁的潮热有关，但焦虑也与报告的潮热和客观记录的潮热之间的差异有关。了解潮热的潜在心理和生物学机制对于寻找乳腺癌幸存者可接受且有效的治疗方法至关重要。该试点项目将通过评估一个模型来进一步评估心理变量和潮热之间的关系，在该模型中，焦虑敏感性（对唤醒症状的恐惧）是一个关键的个体差异变量，有助于报告乳腺癌幸存者潮热的发生和严重程度。将招募乳腺癌幸存者样本，提供一包调查问卷和日记，并配备 Biolog 监测仪来记录胸骨皮肤电导率，这是目前评估客观潮热的黄金标准。图表摘要将用于获取临床信息。总体目标不仅是了解潮热产生和经历的心理维度，而且为具体的新管理策略提供理论依据。该模型为识别最有可能引发热潮红风险的个体提供了基础，并且可以作为开发新颖的潮热认知行为干预措施的基础。此外，报告的潮热与客观记录的潮热之间差异的个体差异的发现将对测试医学治疗的临床试验的设计和解释产生更广泛的影响。除了乳腺癌幸存者之外，研究结果还将对前列腺癌幸存者和一般女性群体所经历的潮热产生影响，其中大多数人在某些时候也会经历潮热。此外，这项研究的结果可能对其他形式的癌症相关症状困扰的管理有影响。该项目研究了为什么一些接受乳腺癌治疗的女性在自然绝经期间会比健康女性经历更强烈和更频繁的潮热。目标是利用认知行为技术制定更好的潮热自我管理策略。