The International Symposium on Regulatory Peptides

描述(由申请人提供)：第17届国际调节肽研讨会计划于2009年1月25-28日在加利福尼亚州圣巴巴拉的费斯帕克双树度假村举行。肠道调节肽是一组结构不同的分子信使，它们不仅在胃肠道(GI)而且在整个生物体中发挥着丰富的信息交换系统网络的功能。调节肽在胎儿/出生后发育、调节多种生理功能，包括脑/肠道通讯和调节摄食量、参与细胞修复/再生反应以及促进增殖性和炎症性疾病等方面的作用日益明显。因此，这些多肽的功能和治疗意义可以非常广泛。胃肠调节多肽和神经肽及其受体和信号通路一直是研究的重点，包括胃泌素释放肽(GRP)、促肾上腺皮质激素释放因子(CRF)、胆囊收缩素(CCK)、胃泌素、甘丙肽、GLP-1、GLP-2、GIP、GRELIN、胃动素、神经降压素、酪氨酸酪氨酸(PYY)、速激肽和血管活性肠肽。这些多肽在不同的学科中引起了极大的兴趣，包括胃肠道系统对食物摄入的高度局部神经内分泌调节。因此，迫切需要一个中央论坛来比较和分享信息、讨论假设并为未来产生新的概念。国际调节性多肽研讨会(REGPEP)聚集了主要的研究人员，介绍他们的最新发现，并在该领域的中心问题背景下讨论他们的数据。这是一个由来自领先国际实验室的200多名研究人员参加的两年一次的会议，他们研究肠道调节肽的表达、受体信号和功能属性。本着国际精神，会议地点在不同的大洲轮流举行；第一次研讨会于1976年在加利福尼亚州的阿西洛马举行。本次研讨会的特色之一是为表彰维克托·穆特在胃肠道多肽激素和神经肽领域的基础研究而设立的维克托·穆特讲座。自1994年以来，该奖项每两年在国际调节肽研讨会上颁发一次。会议的主要目标有三个：1)提供一个中心论坛，在研究人员中传播新的和大部分未发表的信息，作为促进研究的一种手段；2)确定该领域的重要主题和技术进步，目标是临床治疗；以及3)吸引年轻的新研究人员到该领域促进未来的研究。从以往的会议来看，国际实验室之间的互动一直是激动人心的、强有力的和持久的；第17届国际专题讨论会的目标是继续这种信息和技术转让，以加快新的发展。

DESCRIPTION (provided by applicant): The 17th International Symposium on Regulatory Peptides is planned for January 25-28, 2009 at the Fess Parker's Doubletree Resort, Santa Barbara, California. Gut regulatory peptides are a structurally diverse group of molecular messengers that function in a rich network of information exchange systems not only in the gastrointestinal (GI) tract but also throughout the organism. The prominent roles of regulatory peptides in fetal/postnatal development, modulation of diverse physiological functions, including brain/gut communication and regulation of food intake, participation in cellular repair/regeneration responses and contributing to proliferative and inflammatory diseases have been increasingly evident. Accordingly, the functional and therapeutic significance of these peptides can be exceedingly broad. Gut regulatory peptides and neuropeptides, their receptors and signaling pathways have been the subject of intense investigation, including gastrin-releasing peptide (GRP), corticotropin-releasing factor (CRF), cholecystokinin (CCK), gastrin, galanin, GLP-1, GLP-2, GIP, ghrelin, motilin, neurotensin, peptide tyrosine-tyrosine (PYY), tachykinins and vasoactive intestinal peptide. There is extreme interest in these peptides in diverse disciplines, including the highly topical neuroendocrine regulation of food intake by the gastrointestinal system. Accordingly, there is an urgent need for a central forum to compare and share information, discuss hypotheses and generate new concepts for the future. The International Symposium on Regulatory Peptides (REGPEP) brings together leading investigators to present their recent findings and discuss their data in the context of central questions in the field. This is a biennial conference of more than 200 researchers from leading international laboratories studying the expression, receptor signaling and functional attributes of gut regulatory peptides. In keeping with the international spirit, the meeting sites have alternated on different continents; the first symposium was held in 1976 in Asilomar, California. One of the features of this Symposium is the Viktor Mutt Lectureship established in recognition of the fundamental research of Viktor Mutt in the field of gastrointestinal peptide hormones and neuropeptides. It has been awarded since 1994 every two years at the same time of the International Symposium on Regulatory Peptides. The major aims of the conference have been threefold: 1) to provide a central forum to disseminate new and largely unpublished information among investigators as a means of promoting research; 2) to identify important thematic and technological advancements in the field with goals for clinical therapeutics; and 3) to attract young new investigators to the field to foster future research. From previous meetings, the interactions among international laboratories have been stimulating, strong and durable; the 17th International Symposium aims to continue that information and technology transfer to accelerate new developments.