DNA Replication and Genome Integrity

DNA 复制和基因组完整性

• 批准号: 7541293
• 负责人: Judith L CAMPBELL
• 金额: $ 0.9万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7541293
• 关键词: Aging; Area; Arts; Biotechnology; California; Chromatin Structure; Complement; DNA Repair; DNA biosynthesis; Depth; Development; Diagnosis; Disease; Ensure; Epigenetic Process; Etiology; Genome; Genomic Instability; Health; Human; Immune system; Institutes; Link; Location; Nerve Degeneration; Numbers; Participant; Proteins; Research; Research Personnel; Students; System; Technology; abstracting; cancer therapy; concept; cost; design; experience; novel; professor; repaired; success; symposium; telomere

DESCRIPTION (provided by applicant): The fifth biennial Salk-Caltech Conference on DNA Replication and Genome Integrity will be held at the Salk Institute, La Jolla, California, July 18-July 22, 2008 and henceforth in even years. The conference will provide up to 350 places for students, postdocs, professors and biotechnology researchers to meet and discuss novel findings of the past year. Due to its West coast location, increased participation from West coast and Pacific labs is expected. The conference is designed to fulfill the need for an annual conference on this topic generated by the rapidly increasing activity in this field. Advances in this area are continuing to impact significantly on issues related to human health, including the etiology, diagnosis and treatment of cancer, aging, and myriad diseases related to development, the immune system, and neural degeneration. The underlying theme of the meeting will be consideration of genomic instability, to encourage a deeper understanding of links between cellular replication and repair systems. Outstanding researchers have been invited to serve as chairs in sessions devoted to Initiation, Fork proteins, Recombination, DNA Repair, Checkpoints and Genome Integrity, Telomeres, Chromatin Structure and Epigenetics. These chairs will provide in-depth introductions to the most important concepts and unresolved problems in each field. All other presentations and attendees will be chosen from abstracts to ensure that the forefront of research is presented and to encourage active participation of younger researchers. Experienced staff of the state of the art Salk Conference Center will administer the meeting. Scientific organizers are Geoffrey Wahl and Matthew Weitzman, of the Salk Institute, Judith Campbell, California Institute of Technology, Susan Forsburg and Oscar Aparicio of Univ. of Southern California. This conference complements intellectually, temporally, and geographically the current biennial DNA replication meeting held at Cold Spring Harbor in odd-numbered years. In summary, the meeting is designed to significantly broaden discussion of the most topical issues confronting eukaryotic DNA replication. In particular, the West Coast venue should provide an additional option for students and postdocs who have been unable to attend East Coast conferences due to the greater cost. Participants' reviews of the first four meetings confirm its great success.

描述（由申请人提供）：第五届两年一度的索尔克-加州理工学院DNA复制和基因组完整性会议将于2008年7月18日至7月22日在加州拉霍亚的索尔克研究所举行，此后将在偶数年举行。会议将为学生、博士后、教授和生物技术研究人员提供多达350个名额，以讨论过去一年的新发现。由于其位于西海岸，预计西海岸和太平洋实验室的参与将增加。会议旨在满足该领域活动迅速增加所产生的关于这一主题的年度会议的需要。该领域的进展继续对与人类健康相关的问题产生重大影响，包括癌症、衰老以及与发育、免疫系统和神经变性相关的无数疾病的病因学、诊断和治疗。会议的基本主题将是考虑基因组的不稳定性，以鼓励更深入地了解细胞复制和修复系统之间的联系。杰出的研究人员已被邀请担任主席会议致力于启动，叉蛋白，纯化，DNA修复，检查点和基因组完整性，端粒，染色质结构和表观遗传学。这些讲座将深入介绍每个领域中最重要的概念和尚未解决的问题。所有其他演讲和与会者将从摘要中选择，以确保研究的最前沿，并鼓励年轻研究人员的积极参与。最先进的索尔克会议中心的经验丰富的工作人员将管理会议。科学组织者是索尔克研究所的杰弗里·瓦尔和马修·韦茨曼，加州理工学院的朱迪思坎贝尔，南加州大学的苏珊·福斯堡和奥斯卡·阿帕里西奥。这次会议补充智力，时间，和地理上目前两年一度的DNA复制会议在冷泉港在奇数年举行。总之，会议的目的是显着扩大讨论的最热门的问题所面临的真核DNA复制。特别是，西海岸的场地应该为那些由于费用较高而无法参加东海岸会议的学生和博士后提供额外的选择。与会者对前四次会议的回顾证实会议取得了巨大成功。