Closed-Loop Functional Diffuse Optical Tomography (fDOT) Imaging System for Traum

用于创伤的闭环功能性漫射光学断层扫描 (fDOT) 成像系统

• 批准号: 7498971
• 负责人: RANDALL LOCKE BARBOUR
• 金额: $ 43.36万
• 依托单位: PHOTON MIGRATION TECHNOLOGIES CORP
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498971
• 关键词: Affect; Anatomy; Area; Automobile Driving; Back; Brain; Brain Injuries; Brain imaging; Calibration; Clinical; Clinical Management; Clinical Research; Clinical Trials; Cognitive; Collaborations; Complement; Complex; Computer software; Data; Data Collection; Data Set; Detection; Development; Development Plans; Diagnosis; Diffuse; Economics; Engineering; Enterochromaffin Cells; Environment; Evaluation; Event; Facilities and Administrative Costs; Focal Brain Injuries; Functional Magnetic Resonance Imaging; Goals; Head; Helmet; Hemoglobin; Image; Image Analysis; Impaired cognition; Information Systems; International; Language; Legal patent; Lesion; Location; Maps; Marketing; Measurement; Measures; Medical; Methods; Metric; Monitor; Morphologic artifacts; Multivariate Analysis; Neocortex; Neurosciences; Optics; Participant; Patients; Pattern; Performance; Phase; Phase II Clinical Trials; Physiological; Placement; Population; Positioning Attribute; Positron-Emission Tomography; Property; Protocols documentation; Publishing; Purpose; ROC Curve; Recovery; Research; Scanning; Series; Services; Severities; Shapes; Short-Term Memory; Signal Transduction; Solutions; Source; Statistical Methods; Statistically Significant; Surface; System; Techniques; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Traumatic Brain Injury; United States; Update; Validation; base; community planning; cost; density; design; detector; diffuse optical tomography; disability; executive function; experience; follow-up; healthy volunteer; hemodynamics; image visualization; improved; instrument; interest; neuroimaging; novel; optical fiber; productivity loss; programs; prototype; rehabilitation service; research study; response; size; software systems; technology development; tool; voltage

DESCRIPTION (provided by applicant): We plan to expand the development and clinically validate a closed-loop functional neuroimaging system for the purpose of evaluating subjects with traumatic brain injury (TBI). The considered functional Diffuse Optical Tomography (fDOT) imaging system offers a comprehensive solution to the problem of exploring, in real-time, event related hemodynamic responses from essentially area of the head. Supporting this capability has been the development, under Phase I support, of a novel helmet design that can accommodate dense arrays of optical fibers and that can be quickly and easily adapted to comfortably examine essentially any head geometry. Complementing this capability has also been significant advances in instrument system capabilities and analysis software. Still another significant advance, has been the development of a programmable head-shaped calibrating phantom that can accurately mimic essentially any time-varying hemodynamic response with high fidelity and temporal accuracy. This capability is made possible through use of electrochromic materials whose optical properties can be rapidly and accurately modulated by adjustment of the driving voltage. By simply programming the Diffuse Optical Tissue Simulator (DOTS) phantom to mimic clinical findings of interest, true image features can be reliably distinguished from artifact. This unique and patented capability represents a significant advance in the effort to obtain objective and routine system validation of complex physiological states. The experimental plan calls for improvements to our data collection hardware and to update our instrument and analysis software in ways that (i) support examination of larger size data sets and (ii), permit mapping of image features to the underlying anatomy, and to follow this by a clinical study that will explore different aspects of executive function (working memory, language initiation) in healthy volunteers and subjects with TBI. These results will be analyzed to produce statistical maps of group differences for selected parameters from which we can derive composite measures based on multivariate analysis methods. Finally, we will independently validate the image results by comparing the fDOT image findings to fMRI and clinical findings, and to results obtained using our DOTS phantom. The plan development will complement our already advanced imaging system that has attracted growing demand for which systems are in use in eleven leading research centers world-wide. We are confident that the considered system design and capabilities will open a large market opportunity in support of clinical management of TBI and to the neuroscience community. Planned is the development of an inexpensive brain imaging system able to detect and monitor Traumatic Brain Injury, which affects 2.5-6.5 million people and costs an estimated 48.3 billion in the US each year. The core technology will be updated and preliminary results will be followed up with a clinical trial that focuses on analyzing brain function in TBI patients and healthy volunteers. In order to fully validate this technology, results of the clinical trial will be compared to fMRI experiments performed on the same patient population, as well as a dynamic phantom study.

描述（由申请人提供）：我们计划扩大开发和临床验证闭环功能性神经成像系统，用于评估创伤性脑损伤（TBI）受试者。所考虑的功能性扩散光学断层扫描（fDOT）成像系统提供了一个全面的解决方案，以探索，在实时的问题，事件相关的血液动力学反应，从基本区域的头部。支持这种能力的是在第一阶段支持下开发的一种新型头盔设计，该头盔设计可以容纳密集的光纤阵列，并且可以快速轻松地进行调整，以舒适地检查基本上任何头部几何形状。仪器系统能力和分析软件的重大进步也补充了这一能力。另一个显著的进步是开发了可编程头形校准体模，其可以以高保真度和时间精度准确地模拟基本上任何时变血液动力学反应。这种能力通过使用电致变色材料而成为可能，所述电致变色材料的光学性质可以通过调节驱动电压而快速且准确地调制。通过简单地编程漫射光学组织模拟器（DOTS）体模来模拟感兴趣的临床结果，可以可靠地区分真实图像特征和伪影。这种独特的专利功能代表了在获得复杂生理状态的客观和常规系统验证方面的重大进步。实验计划要求改进我们的数据收集硬件，并更新我们的仪器和分析软件，以便（i）支持检查更大尺寸的数据集，（ii）允许将图像特征映射到基础解剖结构，并通过临床研究探索健康志愿者和TBI受试者执行功能的不同方面（工作记忆，语言启动）。将对这些结果进行分析，以生成选定参数的组差异统计图，从中我们可以基于多变量分析方法得出复合测量值。最后，我们将通过将fDOT图像结果与fMRI和临床结果以及使用DOTS体模获得的结果进行比较来独立验证图像结果。该计划的开发将补充我们已经先进的成像系统，该系统吸引了全球11个领先研究中心不断增长的需求。我们相信，考虑的系统设计和功能将打开一个巨大的市场机会，支持TBI的临床管理和神经科学界。 计划是开发一种廉价的脑成像系统，能够检测和监测创伤性脑损伤，这影响了250 - 650万人，估计每年在美国花费483亿美元。核心技术将得到更新，初步结果将通过一项临床试验进行跟进，该试验的重点是分析TBI患者和健康志愿者的脑功能。为了充分验证这项技术，临床试验的结果将与在相同患者人群中进行的fMRI实验以及动态体模研究进行比较。

项目成果

CapMan: independent investigation of capacity and manipulation with a new working memory paradigm.

CapMan：使用新的工作记忆范式对容量和操作进行独立调查。

• DOI: 10.1007/s11682-013-9282-8
• 发表时间: 2014
• 期刊: Brain imaging and behavior
• 影响因子: 3.2
• 作者: Dobryakova,Ekaterina;Staffaroni,Adam;DeLuca,John;Sumowski,JamesF;Chiaravalloti,Nancy;Wylie,GlennR
• 通讯作者: Wylie,GlennR