Functional Brain Imaging by Optical Tomography

光学断层扫描功能性脑成像

• 批准号: 7500181
• 负责人: RANDALL LOCKE BARBOUR
• 金额: $ 38.27万
• 依托单位: PHOTON MIGRATION TECHNOLOGIES CORP
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7500181
• 关键词: Address; Adopted; Algorithms; Animals; Area; Behavior; Benchmarking; Biological; Blood Vessels; Brain; Brain imaging; Breast; Calibration; Cell Nucleus; Cerebrum; Chest; Classification; Clinical; Clinical Research; Collaborations; Collection; Color; Communities; Complement; Complex; Computer Systems Development; Computer software; Condition; Data; Data Analyses; Data Collection; Data Set; Databases; Dependence; Depth; Development; Disease; Documentation; Electroencephalography; End Point; Engineering; Enterochromaffin Cells; Environment; Evaluation; Event; Evolution; Exhibits; Fingers; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Head; Health; Hemoglobin; Image; Image Enhancement; Imagery; Infant; International; Intrinsic factor; Investigation; Knowledge; Laboratories; Lead; Light; Lighting; Limb structure; Literature; Location; Magnetic Resonance Imaging; Maps; Marketing; Measurable; Measurement; Measures; Methods; Modality; Modeling; Molds; Neurosciences; Noise; Numbers; OSA; Operative Surgical Procedures; Optical Tomography; Optics; Organism; Patients; Performance; Phase; Physics; Physiological; Placement; Planet Mars; Problem Solving; Process; Property; Protocols documentation; Purpose; Range; Rate; Reaction; Recovery; Relative (related person); Reporting; Research; Resolution; Scheme; Secure; Series; Simulate; Site; Software Design; Solutions; Speed; Staging; Structure; Surface; System; Technology; Testing; Time; Tissues; Training; Upper arm; Validation; Variant; Visible Radiation; absorption; base; chromophore; concept; cost; data integrity; density; design; diffuse optical tomography; experience; grasp; hemodynamics; image reconstruction; improved; innovation; instrument; interest; light scattering; liquid crystal; neuroimaging; new technology; novel; novel strategies; physical property; prevent; programs; prototype; quality assurance; reconstruction; response; simulation; software systems; spatiotemporal; symposium; technology development; tool; user-friendly; virtual; web-accessible

DESCRIPTION (provided by applicant): Functional NIRS imaging holds the potential to become a versatile, economical, and compact tool for the study of the detailed dynamics of the vascular response to neuroactivation. While steady progress has been made in hardware development, lagging has been the availability of a software environment that provides for accurate reconstructions on a fast time scale and versatile phantoms well suited to explore the wide range of complex behavior inherent to neuroactivation. Building on significant progress made during Phase I, we have developed a fast and stable image enhancement scheme that can significantly improve the image accuracy of first order reconstructions. Independently, by adopting principles from liquid crystal technology, we have developed programmable dynamic phantoms that mimic complex hemodynamic events with high accuracy, precision and speed. The proposed investigation will combine these two innovations to allow for the systematic optimization and quantitative examination by which dynamic NIRS imaging can explore complex neurovascular states. These efforts complement a broader seven-year technology development plan that has already produced an imaging system now in use at ten leading national and international research centers. The proposed study considers an in-depth optimization of user controllable factors (e.g., optimal selection of illuminating wavelengths, improvements in accuracy of reconstructred images, fine tuning of the image enhancement scheme) so as to determine the underlying accuracy and stability of the integrated technology as a function of a range of parameters intrinsic to the brain. The end point of these studies will be a ground truth validation of the fidelity and accuracy of the NIRS imaging approach developed by our company. Through careful optimization of the principal system components, we are confident that the combination of new technologies, and innovative improvements to our software environment will lead to the broad acceptance of NIRS imaging as a versatile and accurate neuroimaging tool. The systematic testing and integration of a new image enhancement scheme for functional NIRS imaging and its ground truth validation using an innovative and versatile assessment modality is proposed for the purpose overcoming the key technology barriers preventing the wide acceptance of functional NIRS imaging.

描述（由申请人提供）：功能性近红外光谱成像有可能成为一种通用、经济和紧凑的工具，用于研究血管对神经激活反应的详细动力学。虽然在硬件开发方面取得了稳步进展，但软件环境的可用性一直滞后，该软件环境提供了快速时间尺度上的准确重建和非常适合探索神经激活固有的广泛复杂行为的多功能幻影。在第一阶段取得的重大进展的基础上，我们开发了一种快速稳定的图像增强方案，可以显着提高一阶重建的图像精度。独立地，通过采用液晶技术的原理，我们开发了可编程动态幻影，以高准确度，精度和速度模拟复杂的血液动力学事件。拟议的调查将联合收割机这两个创新，允许系统的优化和定量检查，动态近红外成像可以探索复杂的神经血管状态。这些努力补充了一个更广泛的七年技术开发计划，该计划已经产生了一个成像系统，目前在十个领先的国家和国际研究中心使用。所提出的研究考虑了用户可控因素的深入优化（例如，照明波长的最佳选择、重建图像精度的改进、图像增强方案的微调），以便确定集成技术的潜在精度和稳定性作为大脑固有参数范围的函数。这些研究的终点将是我们公司开发的NIRS成像方法的保真度和准确性的地面实况验证。通过对主要系统组件的精心优化，我们相信，新技术的结合以及对我们软件环境的创新改进将使NIRS成像作为一种多功能和准确的神经成像工具得到广泛接受。提出了一种新的功能性近红外光谱成像图像增强方案的系统测试和集成，并使用创新和通用的评估模式进行地面真实验证，以克服阻碍功能性近红外光谱成像广泛接受的关键技术障碍。

项目成果

A wearable multi-channel fNIRS system for brain imaging in freely moving subjects.

• DOI: 10.1016/j.neuroimage.2013.06.062
• 发表时间: 2014-01-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Piper, Sophie K.;Krueger, Arne;Koch, Stefan P.;Mehnert, Jan;Habermehl, Christina;Steinbrink, Jens;Obrig, Hellmuth;Schmitz, Christoph H.
• 通讯作者: Schmitz, Christoph H.

Somatosensory activation of two fingers can be discriminated with ultrahigh-density diffuse optical tomography.

• DOI: 10.1016/j.neuroimage.2011.11.062
• 发表时间: 2012-02-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Habermehl, Christina;Holtze, Susanne;Steinbrink, Jens;Koch, Stefan P.;Obrig, Hellmuth;Mehnert, Jan;Schmitz, Christoph H.
• 通讯作者: Schmitz, Christoph H.

High-resolution optical functional mapping of the human somatosensory cortex.

• DOI: 10.3389/fnene.2010.00012
• 发表时间: 2010-01-01
• 期刊: Frontiers in neuroenergetics
• 作者: Koch, Stefan P;Habermehl, Christina;Obrig, Hellmuth
• 通讯作者: Obrig, Hellmuth

Feasibility of near-infrared spectroscopic tomography for intraoperative functional cerebral monitoring: a primate study.

近红外光谱断层扫描用于术中功能性脑监测的可行性：一项灵长类动物研究。

• DOI: 10.1016/j.jtcvs.2014.07.041
• 发表时间: 2014
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Lee,DanielC;Gevorgyan,Tigran;Graber,HarryL;Pfeil,DouglasS;Xu,Yong;Mangla,Sundeep;Barone,FrankC;Libien,Jenny;Charchaflieh,Jean;Kral,JohnG;Ramirez,SergioA;Simpson,LeRone;Barbour,RandallL
• 通讯作者: Barbour,RandallL

Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG.

• DOI: 10.1364/oe.19.018636
• 发表时间: 2011-09-12
• 期刊: Optics express
• 影响因子: 3.8
• 作者: Habermehl C;Schmitz CH;Steinbrink J
• 通讯作者: Steinbrink J