Development of Selective Nanoporous Sorbents for Radionuclide Decorporation

用于放射性核素修饰的选择性纳米孔吸附剂的开发

• 批准号: 7585451
• 负责人: CHARLES TIMCHALK
• 金额: $ 40万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-10 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7585451
• 关键词: Acute; Affect; Affinity; Animals; Binding; Bioshield; Blood; Breathing; Cesium; Charge; Chelating Agents; Class; Cobalt; Complex; Dermal; Development; Devices; Emergency Situation; Exposure to; Gastrointestinal tract structure; Goals; Human; In Vitro; Kidney; Laboratories; Licensure; Liquid substance; Medical; Mission; National Security; Neptunium; Nuclear; Odds Ratio; Oral; Pacific Northwest; Plutonium; Public Health; Radioisotopes; Rate; Research; Route; Safety; Silicon Dioxide; Site; Solid; System; Toxic effect; United States Dept. of Health and Human Services; United States Food and Drug Administration; United States National Institutes of Health; Uranium; Validation; absorption; chelation; cost; design; dirty bomb; in vivo; monolayer; nanoengineering; novel; research study; wasting

The Department of Health and Human Services has charged NIH with the mission of developing new medical countermeasures against radiological or nuclear attacks. As part of Project Bioshield, NIH has established a research goal of developing novel radionuclide chelation and decorporation agents for protection against terrorist attacks that involve radiological dispersion devices (ROD), (e.g. dirty bombs) or nuclear detonations. This project will focus on new product development and validation to minimize systemic exposure to radionuclides through novel chelating materials. We propose to develop and validate in animal (in vivo) and human (in vitro) systems new nano-engineered solid sorbents, which have advantages over :heir liquid counterparts in minimizing the absorption of harmful agents into the body and thereby reducing the kidney burden for clearing the radionuclide-bound complex. At the Pacific Northwest National Laboratory (PNNL), a new class of nano-engineered sorbents, self-assembled monolayer on mesoporous supports (SAMMS) materials, has been developed to facilitate the cleanup of radionuclides from complex waste found at the DOE sites. Created by installation of well-designed organic moieties onto the highly ordered mesoporous silica, the SAMMS materials have been demonstrated to be highly effective chelators for Plutonium, neptunium, uranium, americium, radioiodide, cesium and cobalt, all of which can be normally found in nuclear bombs and ROD. The current proposal focuses on extending the application of SAMMS from their proven utility in environmental clean-up to their utility for radionuclide decorporation in humans. The overall goal of this project is to develop and validate SAMMS materials, and evaluate their toxicity (if any) for use in decorporation of humans following acute exposures to radionuclides. The approach focuses on two specific applications: (1) to chelate radionuclides within the gastrointestinal tract in order to limit systemic absorption of ingested materials and (2) to chelate radionuclides in blood that have been absorbed systemically from all routes of exposure (oral, dermal and inhalation). It is anticipated that the proposed experiments will demonstrate that SAMMS can outperform current FDA-approved ehelation therapies by having higher binding affinity and selectivity for the target radionuclides among other non-target species, larger sorption capacity and rapid sorption rate, favorable benefit to risk ratio, and will be available at low costs. Once we have established increased efficacy and safety of SAMMS for radionuclide decorporation, candidate SAMMS will be advanced towards FDA licensure, with a goal of accelerated deployment to protect the public during a nuclear incident that may cause a public health emergency affecting national security.

卫生与公众服务部已向NIH提出使命， 针对放射性或核攻击的医学对策。作为生物盾牌项目的一部分，NIH 确立了开发新型放射性核素螯合剂和去离子剂的研究目标， 防止涉及放射性弥散装置（ROD）（例如脏弹）的恐怖袭击，或 核爆炸。该项目将侧重于新产品的开发和验证，以尽量减少系统性 通过新型螯合材料暴露于放射性核素。我们建议在动物中开发和验证 (in体内）和人类（体外）系统的新的纳米工程固体吸附剂，其具有优于 ：他们的液体同行在最大限度地减少吸收有害物质进入体内，从而减少 清除放射性核素结合复合物的肾脏负担。在太平洋西北国家实验室 （PNNL），一类新型纳米工程吸附剂，在介孔载体上自组装单层 （SAMMS）材料，已被开发出来，以促进从复杂的废物中清除放射性核素， 在能源部现场通过将精心设计的有机部分安装到高度有序的 作为介孔二氧化硅，SAMMS材料已被证明是高效的螯合剂， 钚，镎，铀，镅，放射性碘，铯和钴，所有这些都可以正常 在核弹和ROD中发现。目前的建议侧重于扩大SAMMS的应用范围 从它们在环境清理中的已被证明的效用到它们在人体中的放射性核素消除的效用。 本项目的总体目标是开发和验证SAMMS材料，并评估其毒性（如果 任何）用于在急性暴露于放射性核素之后的人体的去污。该方法侧重于 在两个具体的应用：（1）螯合胃肠道内的放射性核素，以限制 摄入物质的全身吸收和（2）螯合血液中已吸收的放射性核素 通过所有接触途径（口服、皮肤和吸入）全身接触。预计拟议的 实验将证明，SAMMS可以优于目前FDA批准的治疗方法， 在其它非靶物质中对靶放射性核素具有更高的结合亲和力和选择性， 较大的吸附容量和快速的吸附速率，有利的效益风险比，并将在低 成本一旦我们确定SAMMS用于放射性核素清除的有效性和安全性增加， 候选SAMMS将提前获得FDA许可，目标是加速部署，以保护 核事故期间可能引发影响国家安全的突发公共卫生事件的公众。

项目成果

Selective capture of radionuclides (U, Pu, Th, Am and Co) using functional nanoporous sorbents.

• DOI: 10.1016/j.jhazmat.2018.12.043
• 发表时间: 2019-03
• 期刊: Journal of hazardous materials
• 影响因子: 13.6
• 作者: W. Yantasee;G. Fryxell;Kanda Pattamakomsan;Thanapon Sangvanich;R. Wiacek;B. Busche;R. Addleman;C. Tim

Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis.

• DOI: 10.1016/j.nano.2009.05.002
• 发表时间: 2010-02
• 期刊: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
• 影响因子: 5.4
• 作者: Yantasee, Wassana;Fryxell, Glen E.;Porter, George A.;Pattamakomsan, Kanda;Sukwarotwat, Vichaya;Chouyyok, Wilaiwan;Koonsiripaiboon, View;Xu, Jide;Raymond, Kenneth N.
• 通讯作者: Raymond, Kenneth N.

Phosphate removal by anion binding on functionalized nanoporous sorbents.

• DOI: 10.1021/es100787m
• 发表时间: 2010-04-15
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Chouyyok, Wilaiwan;Wiacek, Robert J.;Pattamakomsan, Kanda;Sangvanich, Thanapon;Grudzien, Rafal M.;Fryxell, Glen E.;Yantasee, Wassana
• 通讯作者: Yantasee, Wassana

Functionalized nanoporous silica for the removal of heavy metals from biological systems: adsorption and application.

• DOI: 10.1021/am100616b
• 发表时间: 2010-10
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Yantasee, Wassana;Rutledge, Ryan D.;Chouyyok, Wilaiwan;Sukwarotwat, Vichaya;Orr, Galya;Warner, Cynthia L.;Warner, Marvin G.;Fryxell, Glen E.;Wiacek, Robert J.;Timchalk, Charles;Addleman, R. Shane
• 通讯作者: Addleman, R. Shane

Selective capture of cesium and thallium from natural waters and simulated wastes with copper ferrocyanide functionalized mesoporous silica.

• DOI: 10.1016/j.jhazmat.2010.06.019
• 发表时间: 2010-10-15
• 期刊: JOURNAL OF HAZARDOUS MATERIALS
• 影响因子: 13.6
• 作者: Sangvanich, Thanapon;Sukwarotwat, Vichaya;Wiacek, Robert J.;Grudzien, Rafal M.;Fryxell, Glen E.;Addleman, R. Shane;Timchalk, Charles;Yantasee, Wassana
• 通讯作者: Yantasee, Wassana