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Mechanisms of signaling in otoconial organs

耳锥器官的信号传导机制

基本信息

批准号：
7324084
负责人：
ELLENGENE H PETERSON
金额：
$ 58.03万
依托单位：
OHIO UNIVERSITY ATHENS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2011-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7324084
关键词：
Address Animals Attention Auditory Award Behavior Biological Models Biomechanics Build-it Cell model Clinical Computing Methodologies Coupling Data Databases Diagnosis Elements Figs - dietary Foundations Frequencies Functional disorder Goals Hair Hair Cells Head Movements In Situ In Vitro Information Theory Knowledge Labyrinth Lead Learning Left Magnetic Resonance Imaging Measurement Measures Mechanics Medical Membrane Mission Modeling Movement Organ Pattern Peripheral Physicians Posture Preparation Process Property Research Research Personnel Semicircular canal structure Shapes Signal Transduction Source Space Perception Speed Staging Stimulus Structure System Systems Analysis Testing Time Turtles Type I Hair Cell Utricle structure Video Recording Visit Work base cell type electrical property gaze improved macula multidisciplinary programs research study response sensory system social

项目摘要

Project summary. Normal behavior and spatial orientation depend upon vestibular signals from the inner ear. There are two major subdivisions of the vestibular periphery: semicircular canals and otoconial organs. The former have been intensively studied. Otoconial organs are much less well understood, even though studies of central vestibular processing increasingly highlight their importance in control of posture, gaze, spatial orientation, and vegetative functions. Thus, there is a pressing need to understand this important subdivision of the labyrinth. We propose to address this need by analyzing the mechanical and biophysical origins of signals from a major otoconial organ, the utricle. Our experimental preparation is a turtle, one of the premier model systems for analyses of peripheral auditory and vestibular mechanisms. This multidisciplinary initiative analyzes utricular mechanisms at levels from behavior to cellular modeling. It builds on results from our current studies of biomechanics, which have yielded the most detailed data base on the structure and mechanics of the utricle available for any vertebrate. Aim 1 uses high-speed video recording and NMR images of the labyrinth to quantify the stimuli that utricular hair cells are exposed to in freely behaving animals. Aim 2 and Aim 3 combine experimental mechanics with biophysical and computational analyses to characterize important mechanical and hair cell responses to these stimuli. Aim 4 uses morphophysiology, information analysis, and modeling to quantify the resulting afferent signals and their information content, contrast these signals with hair cell responses to the same stimuli, and test hypotheses about the origins of signal diversity in utricular afferents. Thus, the proposed research continues our efforts to build the first detailed, quantitative description of the mechanisms that shape utricular signals to the CMS. Relevance. Vestibular dysfunction is a common cause of physician visits. It can be particularly disabling, and vestibular deficits are thus a significant medical, social, and financial concern. In spite of its importance, the vestibular system, and otoconial organs in particular, are far less well understood than other sensory systems. We need new knowledge of otoconial organ function to improve diagnosis and treatment strategies. By contributing to this knowledge, the proposed research is directly relevant to the mission of the NIDCD.

项目总结。正常的行为和空间方向取决于来自内部的前庭信号