Vestibular Regulation of Respiratory Muscle Activity
呼吸肌活动的前庭调节
基本信息
- 批准号:7317349
- 负责人:
- 金额:$ 26.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-05-01 至 2009-11-30
- 项目状态:已结题
- 来源:
- 关键词:AbbreviationsAbdomenAbdominal MusclesAirAir MovementsAnimalsApplications GrantsAxonBilateralBreathingCellsCharacteristicsChestComplement component C1sComplexConsciousContractsDimensionsEmeticsExcisionExhibitsFigs - dietaryFire - disastersForce of GravityFundingGrantIndiumInjection of therapeutic agentInterneuronsLabyrinthLocationLungMedialMediatingMotion SicknessMotorMotor ActivityMotor NeuronsMovementMuscleMuscle ContractionNeural PathwaysNeuronsPathway interactionsPatternPerfusionPharmaceutical PreparationsPhasePhysiologicalPostureProne PositionPumpRateRegulationResearch PersonnelResistanceRespiratory DiaphragmRespiratory MusclesRespiratory SystemReticular FormationRoleRotationShapesSignal TransductionSpinalSpinal CordStomachSuid Herpesvirus 1SystemTestingThoracic cavity structureThoracic spinal cord structureVestibular NerveVestibuleVomitingexpirationgastrointestinallabyrinthectomyneural circuitpressureprogramsrelating to nervous systemresearch studyrespiratoryrespiratory reflexresponse
项目摘要
A variety of experimental approaches have established that the vestibular system contributes to making
adjustments in the activity of thoracic and abdominal respiratory pump muscles as well as muscles that
regulate the resistance of the upper airway during movement and changes in posture. However, these effects
are complex, such that the physiological role of the vestibular system in regulating the movement of air in and
out of the lungs is not yet clear. Specific Aim 1 of the current proposal will determine this role by examining
the consequences of a bilateral labyrinthectomy on the pressure, volume, and flow rate of air exchanged
during inspiration and expiration as body orientation with respect to gravity is altered. Prior experiments have
also shown that some of the neurons that relay vestibular signals to respiratory motoneurons are located in
the medial medullary reticular formation, but that these cells are insufficient to produce vestibulo-respiratory
responses. Our anatomical studies and physiological studies by others have revealed that additional
premotor respiratory neurons are located in the spinal cord. Specific Aim 2 will test the hypothesis that spinal
interneurons are elements in the neuronal circuit that mediates vestibular system influences on the movement
of air in and out of the lungs. Patterned contractions of respiratory muscles are additionally responsible for
producing vomiting; vestibular signals trigger this motor activity during emesis associated with motion
sickness. However, the neural circuit that elicits vomiting has not yet been established, although recent
evidence suggests that cells in the medial medullary reticular formation are important components in this
pathway. Specific Aim 3 will test the hypothesis that medial medullary reticular formation neurons coordinate
the patterned discharges of respiratory muscles that underlie vomiting, including emesis associated with
motion sickness. Together, these experiments should establish the particular role that labyrinthine signals
serve in adjusting the activity of respiratory muscles to compensate for the effects of gravity on these
muscles, the airways, and the lungs. In addition, the location and physiological characteristics of premotor
neurons that mediate labyrinthine influences on respiratory motoneuron firing, both during postural alterations
and emesis, will be ascertained.
各种各样的实验方法已经证实,前庭系统有助于制造
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BILL J YATES其他文献
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{{ truncateString('BILL J YATES', 18)}}的其他基金
Vestibular Regulation of Respiratory Muscle Activity
呼吸肌活动的前庭调节
- 批准号:
7901252 - 财政年份:2009
- 资助金额:
$ 26.89万 - 项目类别:
Vestibular Influences on Head Direction Cell Activity
前庭对头部方向细胞活动的影响
- 批准号:
6614167 - 财政年份:2003
- 资助金额:
$ 26.89万 - 项目类别:
Vestibular Influences on Head Direction Cell Activity
前庭对头部方向细胞活动的影响
- 批准号:
6736307 - 财政年份:2003
- 资助金额:
$ 26.89万 - 项目类别:
MONOAMINERGIC INFLUENCES ON VESTIBULO-SPINAL REFLEXES
单胺能对前庭脊髓反射的影响
- 批准号:
6642899 - 财政年份:2002
- 资助金额:
$ 26.89万 - 项目类别:
MONOAMINERGIC INFLUENCES ON VESTIBULO-SPINAL REFLEXES
单胺能对前庭脊髓反射的影响
- 批准号:
6488242 - 财政年份:2001
- 资助金额:
$ 26.89万 - 项目类别:
MONOAMINERGIC INFLUENCES ON VESTIBULO-SPINAL REFLEXES
单胺能对前庭脊髓反射的影响
- 批准号:
6338724 - 财政年份:2000
- 资助金额:
$ 26.89万 - 项目类别:
MONOAMINERGIC INFLUENCES ON VESTIBULO-SPINAL REFLEXES
单胺能对前庭脊髓反射的影响
- 批准号:
6201737 - 财政年份:1999
- 资助金额:
$ 26.89万 - 项目类别:
MONOAMINERGIC INFLUENCES ON VESTIBULO-SPINAL REFLEXES
单胺能对前庭脊髓反射的影响
- 批准号:
6104507 - 财政年份:1998
- 资助金额:
$ 26.89万 - 项目类别:
Vestibular Regulation of Respiratory Muscle Activity
呼吸肌活动的前庭调节
- 批准号:
7039304 - 财政年份:1998
- 资助金额:
$ 26.89万 - 项目类别:
Vestibular Regulation of Respiratory Muscle Activity
呼吸肌活动的前庭调节
- 批准号:
6468276 - 财政年份:1998
- 资助金额:
$ 26.89万 - 项目类别:
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