Behavioral and fMRI Study: Social Reciprocity in Schizotypal Personality Disorder

行为和功能磁共振成像研究：精神分裂型人格障碍的社会互惠

• 批准号: 7370949
• 负责人: Chandlee Camille Dickey
• 金额: $ 23.63万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-09 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7370949
• 关键词: Affect; Age; Anger; Antipsychotic Agents; Anxiety; Behavior; Behavioral; Books; Cheek structure; Communities; Computer information processing; Computer software; Computers; Curiosities; DSM-IV; Depth; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Disease; Disease susceptibility; Education; Emotional; Emotions; Ensure; Event; Exhibits; Exploratory Behavior; Expressed Emotion; Face; Facial Expression; Failure; Family; Feeling; Figs - dietary; Friends; Fright; Functional Magnetic Resonance Imaging; Gender; Genetic; Hearing; Human; Image; Impairment; Language; Lead; Length; Longevity; Magnetic Resonance Imaging; Matched Group; Measures; Methods; Mission; Monitor; Moods; Motor output; Mus; Neuroanatomy; Neurobiology; Numbers; Occupational; Oral cavity; Output; Patients; Pattern; Personality inventories; Persons; Pharmaceutical Preparations; Process; Production; Questionnaires; Range; Rate; Reading; Recruitment Activity; Rehabilitation Research; Research; Schizophrenia; Schizotypal Personality Disorder; Score; Scoring Method; Self-Administered; Sensory; Sensory Process; Series; Shyness; Signal Transduction; Social Behavior; Socioeconomic Status; Speech; Speed; Stress; Structure of middle temporal gyrus; Structure of superior temporal sulcus; Time; Training; Unemployment; Variant; Videotape; Visual attention; Voice; Work; abstracting; base; behavior measurement; blind; computer generated; disorder control; expectation; experience; functional outcomes; remediation; research study; severe mental illness; showing emotion; social; social reciprocity; social rehabilitation; tool; trait; virtual; virtual human

DESCRIPTION (provided by applicant): Social impairment is a prominent feature of schizotypal personality disorder (SPD) and is often manifested in subjects by having few friends and long periods of unemployment. It is hypothesized that a combination of input and output emotional processing deficits explains the social and occupational failure of SPD subjects. In this R21 resubmission application simple sensory input and motor output of emotional faces and prosody will be compared in SPD and control subjects. The main hypothesis is that DSM-IV diagnosed SPD subjects, compared with control subjects, will exhibit deficits in information processing essential to social reciprocity (i.e., sensory processing of facial emotions and emotional prosody), and also deficits in the motoric output of signals related to social reciprocity (i.e., facial expressions and voice inflection), which are needed to convey social and emotional meaning. These four aspects of social reciprocity will be studied using behavioral measures, a computer-derived emotional expression task, videotapes, pitch analysis (measure of prosody), as well as by structural and functional MRI (fMRI). To achieve these aims, 24 neurolepticnaive SPD subjects age, gender, parental socio- economically matched to 24 comparison subjects, will be recruited from the community. A further rationale for studying SPD subjects is they are not psychotic and have not received neuroleptic medications. Yet SPD subjects share the same genetic diathesis as schizophrenia, and thus offer a unique opportunity to examine the behavior and the functional neuroanatomy of schizophrenia spectrum disorders, without multiple researches confounds such as medication effects and stress due to serious mental illness. Relevance to NIMH's mission: Understanding fundamental abnormalities in social reciprocity in SPD could have a significant impact on our conceptualization of these deficits in schizophrenia, which, in turn, might stimulate further social rehabilitation research.

描述（由申请人提供）：社交障碍是分裂型的一个突出特征 人格障碍（SPD），通常表现在受试者很少有朋友和长时间的 失业据推测，输入和输出的情绪处理缺陷的组合 解释了社会和职业失败的SPD科目。在此R21重新提交申请中 简单的感觉输入和运动输出的情绪面孔和韵律将比较在SPD和 控制对象。主要假设是DSM-IV诊断为SPD受试者，与对照组相比， 受试者，将表现出对社会互惠至关重要的信息处理的缺陷（即，感官 面部情绪和情绪韵律的处理），以及信号的运动输出缺陷 与社会互惠有关（即，面部表情和语音变化），这是需要传达 社会和情感意义。这四个方面的社会互惠将研究使用行为 测量，计算机衍生的情感表达任务，录像带，音高分析（测量 韵律学），以及结构和功能MRI（fMRI）。为了实现这些目标，24名未接受过神经安定药的人 SPD受试者的年龄、性别、父母的社会经济状况与24名对照受试者相匹配， 从社区招募。研究SPD受试者的另一个理由是他们不是精神病患者 并且没有接受过精神抑制药物治疗。然而，SPD受试者与其他人具有相同的遗传素质， 精神分裂症，从而提供了一个独特的机会，检查行为和功能 精神分裂症谱系障碍的神经解剖学，没有多个研究混淆， 药物的影响和压力，由于严重的精神疾病。与NIMH使命的相关性： 了解社会民主党社会互惠的基本异常可能会产生重大影响 我们对精神分裂症中这些缺陷的概念化，这反过来可能会刺激进一步的社会 康复研究。