Stereo Vision Probe: A New PAT Instrument for Real-time Characterisation of Particulate Systems

立体视觉探头：一种用于实时表征颗粒系统的新型 PAT 仪器

• 批准号: EP/E045707/1
• 负责人: Xue Wang
• 金额: $ 43.31万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE045707%2F1
• 关键词: Stereo; Vision; Probe; New; PAT

Research on particle shape is extremely important to many industrial applications such as pharmaceuticals, biopharmaceuticals, human health products and speciality chemicals. For example, for pharmaceuticals, the morphology can affect important properties such as dry powder density, cohesion, and flowability, that can have major impact on a company's ability to formulate drug particles into finished products. Moreover, crystal morphology can affect drug dissolution, potentially affecting formulated product bioavailability and, in extreme, resulting in a companies loss of the license to making the drug product. However, despite the availability of various Process Analytical Technology (PAT) instruments for measuring other properties of particulate systems, there have been no effective on-line instruments capable of providing real-time information on particle shape during the processing of particles in unit operations such as crystallisation, precipitation, granulation and milling. In the past few years, on-line high speed imaging has shown to be a very promising PAT instrument for real-time measurement of particle shape on-line which has resulted in the development of some new instrumentation products just released to the market such as the PVM (Process Vision system) of Lasentec (uk.mt.com), the PIA (Process Image Analyser) of MessTechnik Schwartz GmbH (www.mts-duesseldorf.de), the ISPV (In-Situ Particle Viewer) of Perdix (www.perdix.nl) in Netherlands, and the On-line Microscopy systems of GlaxoSmithKline, some of which incorporate a probe design which allows easy access to a processing reactor vessel. However, all these techniques are essentially limited in that they can only provide 2D information of the particle shape. Hence, this proposed research aims to develop a new instrument Stereo Vision Probe which can directly image the full 3D shape of particles within a practical processing reactor. This basic mode of operation is based on the mathematical principle that if the 2D images of an object are obtained from two different angles, the full 3D particle shape can be recovered. The potential impact on research capability and industrial applications is predicted to be major but the proposed research will focus on the development of the Stereo Vision Probe and the 3D construction method from the two 2D images obtained from two different angles. The testing of the system will be mainly via the use of a variable temperature crystallisation cell.

颗粒形状的研究对于许多工业应用，如制药，生物制药，人类健康产品和特种化学品非常重要。例如，对于药物，形态可以影响重要的性质，例如干粉密度、内聚性和流动性，这可以对公司将药物颗粒配制成成品的能力产生重大影响。此外，晶体形态可影响药物溶解，潜在地影响配制产品的生物利用度，并且在极端情况下，导致公司失去制造药物产品的许可。然而，尽管有各种过程分析技术（PAT）仪器可用于测量颗粒系统的其它性质，但在单元操作（例如结晶、沉淀、造粒和研磨）中的颗粒处理期间，还没有能够提供关于颗粒形状的实时信息的有效在线仪器。在过去的几年中，在线高速成像已被证明是用于在线实时测量颗粒形状的非常有前途的PAT仪器，这导致了一些新仪器产品的开发，这些新仪器产品刚刚投放市场，例如Lasentec（www.example.com）的PVM（过程视觉系统）uk.mt.com、MessTechnik Schwartz GmbH（www.example.com）的PIA（过程图像分析仪）www.mts-duesseldorf.de、荷兰Percoln（www.example.com）的ISPV（原位颗粒观察器）www.perdix.nl以及GlaxoSmithKline的在线显微镜系统。其中一些结合了允许容易地接近处理反应器容器的探针设计。然而，所有这些技术基本上都受到限制，因为它们只能提供颗粒形状的2D信息。因此，本研究的目的是开发一种新的仪器立体视觉探头，可以直接成像的完整的3D形状的颗粒在一个实际的处理反应器。这种基本的操作模式基于数学原理，即如果从两个不同的角度获得物体的2D图像，则可以恢复完整的3D颗粒形状。预计对研究能力和工业应用的潜在影响将是主要的，但拟议的研究将集中在立体视觉探头的开发和从两个不同角度获得的两个2D图像的3D构建方法。该系统的测试将主要通过使用变温结晶池进行。

项目成果

Model identification of crystal facet growth kinetics in morphological population balance modeling of l-glutamic acid crystallization and experimental validation

• DOI: 10.1016/j.ces.2011.05.042
• 发表时间: 2012-03
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: Chao Y. Ma;X. Wang

10th International Symposium on Process Systems Engineering: Part A

第十届过程系统工程国际研讨会：A 部分

• DOI: 10.1016/s1570-7946(09)70341-4
• 发表时间: 2009
• 作者: Ma C

Faceted growth rate estimation of potash alum crystals grown from solution in a hot-stage reactor

• DOI: 10.1016/j.powtec.2012.02.040
• 发表时间: 2012-09
• 期刊: Powder Technology
• 影响因子: 5.2
• 作者: Cai Y. Ma;J. Wan;X. Wang

Crystal Growth Rate Dispersion Modeling Using Morphological Population Balance

• DOI: 10.1002/aic.11549
• 发表时间: 2008-09
• 期刊: Aiche Journal
• 影响因子: 3.7
• 作者: Cai Y. Ma;X. Wang

Closed-loop control of crystal shape in cooling crystallization of l-glutamic acid

• DOI: 10.1016/j.jprocont.2011.10.007
• 发表时间: 2012
• 期刊: Journal of Process Control
• 影响因子: 4.2
• 作者: Chao Y. Ma;X. Wang