NMR facilities to support synthetic chemistry in Nottingham

支持诺丁汉合成化学的核磁共振设施

• 批准号: EP/E04882X/1
• 负责人: Christopher Moody
• 金额: $ 114.78万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE04882X%2F1
• 关键词: NMR; facilities; support; synthetic; chemistry

Nuclear magnetic resonance (NMR) spectroscopy is fundamental to much of modern chemistry for it is an essential technique for identifying new chemical substances. The proposed new NMR facilities will support research at the cutting edge of chemistry in areas ranging from chemical biology and its interface with medicine, through contemporary organic and inorganic chemistry, to new materials. In particular, the equipment will support new projects in catalysis and methodology, the synthesis of naturally occurring bioactive compounds, coordination chemistry including metal-containing enzymes, medicinal chemistry (novel enzyme inhibitors as therapeutic agents) and chemical biology (chemical probes for cellular signaling pathways). Specific goals include new routes to natural products that mimic the ways that Nature assembles such molecules, the study of drug-DNA interactions and RNA-interactive molecules, the extraction of metal salts from waste streams, nanostructures and their applications in materials and electronics, polymers for gas storage, and the utilisation of lignin (a plentiful raw material).

核磁共振光谱学是许多现代化学的基础，因为它是识别新的化学物质的基本技术。拟议的新核磁共振设施将支持化学尖端领域的研究，范围从化学生物学及其与医学的接口，到当代有机和无机化学，再到新材料。特别是，这些设备将支持催化和方法学、天然生物活性化合物的合成、包括金属酶在内的配位化学、药物化学(作为治疗剂的新型酶抑制剂)和化学生物学(细胞信号通路的化学探针)等领域的新项目。具体目标包括模仿大自然组装此类分子的天然产品的新途径，药物与DNA相互作用和RNA相互作用分子的研究，从废物中提取金属盐，纳米结构及其在材料和电子产品中的应用，用于气体储存的聚合物，以及木质素(一种丰富的原材料)的利用。