New molecular tools for the 21st century: Molecular design of new DNA-based devices

21 世纪的新分子工具：新型 DNA 设备的分子设计

• 批准号: EP/E055095/1
• 负责人: Glenn Burley
• 金额: $ 115.81万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE055095%2F1
• 关键词: New; molecular; tools; 21st; century

DNA is a naturally-occurring molecule that is used by nature to store all of the instructions required for the functioning of a living being. DNA achieves this function by storing information not by a binary code (like a hard drive in modern computers), but rather by a genetic code made up of four building blocks (these are known as bases A, G, C, and T). DNA exists in the form of a twisted ladder known as the DNA double helix which is formed only when building block A recognizes and pairs with building block T, and building block G recognizes and pairs with building block C. Recently scientists have shown that these DNA pairs can be used for functions other than the storage and flow of genetic information in living systems. The DNA double helix can now be used for the construction of molecular computers, molecular machines and electronic devices 10,000 times smaller than the current electronic devices used in today's personal computers. The objectives of this research will be the development of new approaches for the construction of electronic, information storage and medical devices based on the genetic code of DNA. We will use the genetic code of A, G, C and T to direct the placement of metals and magnets along a DNA double helix. To achieve this, we need to make different types of molecules that can read DNA's genetic code. We will then investigate whether we can use this code as an address book in order to send a particular metal or magnet to a particular destination along a DNA double helix. This will not only enable us to design electronic devices that are smarter, more efficient and more environmentally friendly than those in current electronic systems, but it will also allow us to use this technology to detect and predict whether specific sequences of DNA (known as genes) in human cells may or may not cause disease.

DNA是一种自然产生的分子，它被大自然用来储存生物功能所需的所有指令。DNA实现这一功能不是通过二进制代码（像现代计算机中的硬盘驱动器）来存储信息，而是通过由四个构建块（称为碱基a、G、C和T）组成的遗传密码。DNA以扭曲的阶梯形式存在，被称为DNA双螺旋结构，只有当构建块a识别并与构建块T配对，构建块G识别并与构建块c配对时才会形成。最近科学家们表明，这些DNA对可以用于生命系统中遗传信息的存储和流动以外的功能。DNA双螺旋结构现在可以用于构建分子计算机、分子机器和电子设备，比目前个人电脑中使用的电子设备小1万倍。这项研究的目标将是开发基于DNA遗传密码的电子、信息存储和医疗设备的新方法。我们将使用A， G， C和T的遗传密码来指导金属和磁铁沿着DNA双螺旋结构的位置。为了实现这一目标，我们需要制造不同类型的分子来读取DNA的遗传密码。然后，我们将研究是否可以使用这个代码作为地址簿，以便沿着DNA双螺旋将特定的金属或磁铁发送到特定的目的地。这不仅使我们能够设计出比现有电子系统更智能、更高效、更环保的电子设备，而且还使我们能够利用这项技术检测和预测人类细胞中特定的DNA序列（称为基因）是否会引起疾病。

项目成果

An RNA splicing enhancer that does not act by looping.

一种不通过环化起作用的 RNA 剪接增强子。

• DOI: 10.1002/anie.201202932
• 发表时间: 2012
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Lewis H

An oligofluorene truxene based distributed feedback laser for biosensing applications.

• DOI: 10.1016/j.bios.2013.11.054
• 发表时间: 2014-04
• 期刊: Biosensors & bioelectronics
• 影响因子: 12.6
• 作者: Anne-Marie Haughey;B. Guilhabert;A. Kanibolotsky;P. Skabara;M. Dawson;G. Burley;N. Laurand

An organic semiconductor laser based on star-shaped truxene-core oligomers for refractive index sensing

• DOI: 10.1016/j.snb.2013.04.026
• 发表时间: 2013-08
• 期刊: Sensors and Actuators B-chemical
• 影响因子: 8.4
• 作者: Anne-Marie Haughey;B. Guilhabert;A. Kanibolotsky;P. Skabara;G. Burley;M. Dawson;N. Laurand

Triazoles from N-Alkynylheterocycles and Their Coordination to Iridium

N-炔基杂环三唑及其与铱的配位

• DOI: 10.1021/om201157g
• 发表时间: 2012
• 期刊: Organometallics
• 影响因子: 2.8
• 作者: Burley G

Highly size- and shape-controlled synthesis of silver nanoparticles via a templated Tollens reaction.

• DOI: 10.1002/smll.201101474
• 发表时间: 2012-03-12
• 期刊: SMALL
• 影响因子: 13.3
• 作者: Dondi, Ruggero;Su, Wu;Griffith, Gerry A.;Clark, Graham;Burley, Glenn A.
• 通讯作者: Burley, Glenn A.