IMPROVING THE CLINICAL APPLICABILITY OF PATHOPHYSIOLOGICAL MODELLING OF HYPOXAEMIA USING ROBUSTNESS ANALYSIS

利用稳健性分析提高低氧血症病理生理学模型的临床适用性

• 批准号: EP/E055486/1
• 负责人: Declan Bates
• 金额: $ 10.51万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE055486%2F1
• 关键词: IMPROVING; CLINICAL; APPLICABILITY; PATHOPHYSIOLOGICAL; MODELLING

The proposed research collaboration will explore the use of robustness analysis methods from advanced control theory for the development, validation and improvement of physiological simulation models. In particular, the applicants will focus on the development of improved models for understanding and managing hypoxaemia and apnoea, which can be validated across representative patient populations, thus significantly enhancing their clinical applicability.

拟议的研究合作将探索使用先进控制理论的鲁棒性分析方法来开发，验证和改进生理模拟模型。特别是，申请人将专注于开发用于理解和管理低氧血症和呼吸暂停的改进模型，这些模型可以在代表性患者人群中进行验证，从而显著增强其临床适用性。

项目成果

A Control Engineering Approach to Calculating Optimal Ventilator Settings for Critically-ill Patients under Mechanical Ventilation

计算危重患者机械通气最佳呼吸机设置的控制工程方法

• 发表时间: 2009
• 作者: Z Gao

Validation of a Matlab simulator for pathophysiological research

用于病理生理学研究的 Matlab 模拟器的验证

• 发表时间: 2009
• 作者: A Das