The various clinical applicability of cultured oral epithelial cells sheet on amniotic membrane

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Autologous oral mucosal epithelial sheets, which were cultivated on amniotic membrane, were used for the transplantation of oral mucosa after oral surgery(9 cases : mucocele ; oral leukoplakia ; pleomorphic adenoma ; lip neoplasm ; and fibroma of buccal mucosa). In 7 of these cases, a favorable post-transplant course was obtained with reproduced oral mucosa without abnormalities at the transplantation site. On the other hand, transplant approaches were not applicable in the remaining 2 cases, in which the diseased portion was removed, involving a substantial loss, suggesting the necessity of examining the appropriate selection of patients and surgical procedures for transplantation.