IMPROVING THE CLINICAL APPLICABILITY OF PATHOPHYSIOLOGICAL MODELLING OF HYPOXAEMIA USING ROBUSTNESS ANALYSIS

利用稳健性分析提高低氧血症病理生理学模型的临床适用性

• 批准号: EP/E056431/1
• 负责人: Jonathan Hardman
• 金额: $ 6.46万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE056431%2F1
• 关键词: IMPROVING; CLINICAL; APPLICABILITY; PATHOPHYSIOLOGICAL; MODELLING

The proposed research collaboration will explore the use of robustness analysis methods from advanced control theory for the development, validation and improvement of physiological simulation models. In particular, the applicants will focus on the development of improved models for understanding and managing hypoxaemia and apnoea, which can be validated across representative patient populations, thus significantly enhancing their clinical applicability.

拟议的研究合作将探索使用先进控制理论的鲁棒性分析方法来开发，验证和改进生理模拟模型。特别是，申请人将专注于开发用于理解和管理低氧血症和呼吸暂停的改进模型，这些模型可以在代表性患者人群中进行验证，从而显著增强其临床适用性。

项目成果

Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study.

爆炸性肺损伤和低血容量休克后院前持续气道正压通气：一项模型研究。

• DOI: 10.1016/j.bja.2021.10.012
• 发表时间: 2022
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Mistry S

Primary blast lung injury simulator: a new computerised model.

原发性爆炸性肺损伤模拟器：一种新的计算机模型。

• DOI: 10.1136/jramc-2018-000989
• 发表时间: 2019
• 期刊: Journal of the Royal Army Medical Corps
• 作者: Haque M

Efficacy of continuous positive airway pressure in casualties suffering from primary blast lung injury: A modeling study.

持续气道正压通气对原发性爆炸性肺损伤伤员的疗效：一项建模研究。

• DOI: 10.1109/embc.2019.8857613
• 发表时间: 2019
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Scott TE