Core E: Statistical Analysis Core

核心E：统计分析核心

• 批准号: 7476545
• 负责人: LAUREL BECKETT
• 金额: $ 1.75万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7476545
• 关键词: Address; Analytical Chemistry; Animal Model; Area; Autistic Disorder; Basic Science; Biochemistry; Bioinformatics; Biometry; Child; Childhood; Clinical; Cohort Studies; Collaborations; Complex; Data; Data Analyses; Databases; Depth; Development; Disease; Disease regression; Environment; Environmental Epidemiology; Environmental Health; Event; Experimental Designs; Faculty; Fostering; Funding; Genes; Genetic; Genetic Risk; Genomics; Goals; Grant; Growth and Development function; Human Resources; Image; Immunology; Incidence; Link; Longitudinal Studies; Methodology; Methods; Mission; Modeling; Nerve Degeneration; Neurodevelopmental Disorder; Population; Principal Investigator; Process; Proteomics; Qi; Range; Rate; Research; Research Design; Research Personnel; Research Support; Role; Sample Size; Services; Severities; Single Nucleotide Polymorphism; Statistical Methods; Students; Study models; Time; Training; Work; Writing; base; data integration; experience; genetic association; genetic risk factor; member; metabolomics; neuroimaging; novel; pre-clinical; programs; statistics

The Statistics Core is new and will be led by Dr. Laurel Beckett, Biostatistics Division Chief. The core will coordinate all the CCEH needs for experimental design, data integration, and statistical analysis. The Core advises on design of studies, linkage of analytic databases across cores and projects, mathematical and statistical analyses, and mechanisms to allow researchers and decision makers to visualize probable consequences of alternative mechanistic models. Dr. Beckett, the Core Leader, has worked with the CCEH since its inception. Her methodological expertise lies in longitudinal cohort studies and modeling of multivariate change processes, and she has many years of experience in collaborative research in neurodegenerative and neurodevelopmental diseases and in studies of growth and development. Dr. Lihong Qi is a new faculty member whose expertise is in biostatistics and has extensive training in conducting methodological research on high-dimensional genetic association single nucleotide polymorphism (SNP) studies. Dr. Nguyen's expertise is in the analysis of high dimensional data, especially genomic expression data, false discovery rate in genomics applications, and covariate-adjusted regression and correlation analysis. Additional expertise is available to Center researchers through the Division of Biostatistics, whose 10 faculty members include experts in genomics, bioinformatics, missing data in longitudinal studies, neuroimaging, and time-to-event data. Dr. Hertz-Picciotto, Deputy Director and Project 1 leader, is an experienced epidemiologic methodologist who will act as the CCEH Liaison to the Statistics Core.

统计核心是新的，将由生物统计局负责人Laurel Beckett博士领导。这 核心将协调实验设计，数据集成和统计的所有CCEH需求 分析。核心为研究设计，跨核心数据库的联系以及 项目，数学和统计分析以及允许研究人员和决策的机制 制造商可视化替代机械模型的可能后果。贝克特博士 核心负责人自成立以来一直与CCEH合作。她的方法论专业知识在于 纵向队列研究和多元变化过程的建模，她有许多 在神经退行性和神经发育方面的合作研究经验多年 疾病和生长和发展研究。 Lihong Qi博士是一名新教师 专业知识是生物统计学的，并且在进行方法论方面进行了广泛的培训 高维遗传关联单核苷酸多态性（SNP）研究。 Nguyen博士 专业知识在于对高维数据的分析，尤其是基因组表达数据，错误 基因组学应用中的发现率以及协变量调整后的回归和相关分析。 通过生物统计学的划分，可以为中心研究人员提供其他专业知识，他们 10位教职员工包括基因组学专家，生物信息学，纵向缺少数据 研究，神经影像和事件时间数据。副主任兼项目1 Hertz-Picciotto博士 领导者是一位经验丰富的流行病学方法学家，他将充当CCEH联络员 统计核心。