Training in Drug Abuse and Brain Imaging

描述(由申请人提供)：这是一项继续进行脑成像和药物滥用方面的博士后研究培训计划的建议。我们拥有各种各样的大脑成像工具，这些工具已经产生了关于大脑奖励系统和成瘾的宝贵信息。需要这样一个专门的项目是因为出现了新的创新技术，可以在与药物滥用有关的各种条件下观察大脑的解剖和功能方面，例如：急性醉酒效应、跟踪线索诱导的渴望、测量认知效果、检测持续的神经和认知缺陷、监测戒断、睡眠障碍、用药依从性、跟踪治疗进展和药物开发。由于成像涉及的学科的性质和范围很复杂，需要一批具有成像技术、神经科学、药理学、成瘾医学和治疗背景的新一代科学家，以更全面地探索药物滥用的神经生物学基础，并填补美国研究中心预计的空缺--这一培训计划旨在填补这一空白。在过去的4年里，我们建立了一个综合的、多学科的药物滥用和脑成像培训计划(DABITP)，该计划由麦克莱恩医院/哈佛医学院和波士顿大学医学院联合支持。在过去的一年里，我们从事了翻译研究，并将于2006年11月安装一块9.4T的磁铁。由于预期NIDA的使命是加强临床前研究与临床研究的结合，我们在培训计划中增加了一条新的赛道。此外，我们还与东北大学药物发现中心合作推出了一个联合P20应用程序，并开始利用彼此的资源来加强翻译研究方面的培训。我们的2-3年博士后培训计划旨在为学员提供MR和EEC技术的基础知识，然后安排在满足学员特定职业目标的四个不同研究轨道之一：1)MR技术和仪器；2)基础临床；3)临床治疗；4)翻译。脑成像和精神药理学的教学培训与各种非常成功的研究实验室的实际应用相结合，将为我们的受训人员提供使用脑成像技术的技能，因为他们将开始下一个十年对上瘾的大脑的研究。

DESCRIPTION (provided by applicant): This is a proposal to continue a postdoctoral research-training program in brain imaging and drug abuse. We have at our disposal a variety of brain imaging tools that have yielded valuable information about brain reward systems and addiction. The need for such a dedicated program is dictated by the emergence of new and innovative techniques to view both the anatomical and functional aspects of the brain under a variety of conditions related to substance abuse such as: acute intoxicating effects, tracking cue-induced craving, measuring cognitive effects, detecting persistent neurological and cognitive defects, monitoring withdrawal, sleep disturbances, medication compliance, tracking treatment progress and medication development. Because the nature and spectrum of the disciplines involved in imaging are complex, a new breed of scientists with backgrounds in imaging technology, neuroscience, pharmacology, addiction medicine and treatment will be needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated vacancies in research centers in the United States-this Training Program is designed to fill this void. Over the past 4 years we established an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that was jointly supported by the McLean Hospital/Harvard Medical School and Boston University School of Medicine. In the past year we have engaged in translational research and will be installing a 9.4T magnet in November 2006. In anticipation of NIDA's mission to enhance the integration of preclinical with clinical research, we have added a new track to our training program. In addition, we also have teamed with the Center for Drug Discovery at Northeastern University in a joint P20 application and have begun to tap into each other's resources to enhance training in translational research. Our 2-3 year postdoctoral training program is structured to provide the trainees with the basics of MR and EEC techniques, which is followed by placement in one of four distinct research tracks that meets the trainees' specific career goals: 1) MR Technology and Instrumentation; 2) Basic Clinical; 3) Clinical Treatment; and 4) Translational. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories will provide our trainees with the skills to employ brain imaging techniques as they embark on the next decade of research on the addicted brain.