Training in Drug Abuse and Brain Imaging

LUKAS，SE药物滥用和成像培训T32 DA015036 - 15 这是一个建议，继续与年16 - 20的博士后培训计划， 大脑成像和药物及酒精滥用我们有各种各样的大脑 这些成像工具对奖励系统和成瘾产生了有价值的见解。的 需要这样一个专门的计划是由新的和创新的出现驱动 技术来查看解剖和功能方面的大脑下， 与药物和酒精滥用相关的各种病症，例如：急性中毒 影响，跟踪线索诱导的渴望，测量认知效果，检测持续性 神经和认知缺陷，监测戒断，睡眠障碍， 用药依从性，跟踪治疗进展和药物开发。 由于成像所涉及的学科的性质和范围是复杂的， 具有成像技术背景的新一代科学家，多模态分析， 神经科学、药理学、成瘾医学和治疗需要更充分地 探索药物滥用的神经生物学基础，并满足 美国--我们的培训计划正在填补这一空白。过去14年来 我们已经成功地指导了一个综合的、多学科的药物滥用和大脑 由McLean医院/哈佛医学中心支持的成像培训计划 学校和马蒂诺斯中心的生物医学成像在MGH。我们的节目 强调临床和转化研究指令，具有坚实的 磁共振[成像，功能和光谱学]，EEG，PET基础 近红外光谱（NIRS）培训的基础设施 该项目围绕两台西门子3T临床扫描仪（TIM Trio和Prisma）构建， Varian 4T临床扫描仪，9.4T小口径动物磁铁，低密度和高密度 EEG/ERP和Imagent NIRS系统。动物和临床PET均可在我们的 MGH网站。我们的导师由NIDA，NIAAA和NIMH提供充足的资金，因此提供 为我们的学员提供独特的研究机会。我们的博士后培训 该计划的结构是为学员提供，在2或3年的过程中， 成像技术的基础知识，其次是在四个不同的研究之一的位置 支持每个受训者特定职业目标的轨道：1）技术和 仪器; 2）基础-临床; 3）临床治疗; 4）转化。在 与Martinos中心合作，我们提供同步PET/MRI培训。的 结合脑成像和精神药理学的教学培训与实践 应用在各种非常成功的研究实验室提供我们的学员 他们有能力利用广泛的大脑成像技术， 下一个十年关于药物和酒精如何影响大脑的研究。

LUKAS, SE Training in Drug Abuse and Imaging T32 DA015036-15 This is a proposal to continue with years 16-20 of a postdoctoral training program in brain imaging and drug and alcohol abuse. We have at our disposal a variety of brain imaging tools that have yielded valuable insights into reward systems and addiction. The need for such a dedicated program is driven by the emergence of new and innovative techniques to view both the anatomical and functional aspects of the brain under a variety of conditions related to drug and alcohol abuse such as: acute intoxicating effects, tracking cue-induced craving, measuring cognitive effects, detecting persistent neurological and cognitive defects, monitoring withdrawal, sleep disturbances, medication compliance, tracking treatment progress and medication development. Because the nature and spectrum of the disciplines involved in imaging are complex, a new breed of scientists with backgrounds in imaging technology, multimodal analyses, neuroscience, pharmacology, addiction medicine and treatment are needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated needs in the United States—our Training Program has been filling this void. Over the past 14 years we have successfully directed an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program that is supported by the McLean Hospital/Harvard Medical School and the Martinos Center for Biomedical Imaging at the MGH. Our program emphasizes both clinical and translational research directives that have solid foundations in magnetic resonance [imaging, functional and spectroscopy], EEG, PET and most recently Near Infrared Spectroscopy (NIRS). The infrastructure of the training program is built around two Siemens 3T clinical scanners (a TIM Trio and a Prisma), a Varian 4T clinical scanner, a 9.4T small bore animal magnet, both low and high density EEG/ERP and an Imagent NIRS system. Both animal and clinical PET is available at our MGH site. Our mentors are well funded by NIDA, NIAAA and NIMH and as such offer a unique breadth of research opportunities for our trainees. Our postdoctoral training program is structured to provide the trainees, over the course of 2 or 3 years, with the basics of imaging techniques, followed by placement in one of four distinct research tracks supporting each trainee's specific career goals: 1) Technology and Instrumentation; 2) Basic-Clinical; 3) Clinical-Treatment; and 4) Translational. In collaboration with the Martinos Center, we offer training in concurrent PET/MRI. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on how drugs and alcohol affect the brain.