Training in Drug Abuse and Brain Imaging

卢卡斯，SE药物滥用和成像培训T32 DA015036-15 这是一项继续16-20年博士后培训计划的建议 脑部成像以及吸毒和酗酒。我们有各种各样的大脑可供支配 成像工具，对奖励系统和成瘾有了有价值的见解。这个 对这种专门计划的需求是由新的和创新的出现推动的 在一种情况下观察大脑的解剖和功能方面的技术 与药物和酒精滥用有关的各种情况，例如：急性醉酒 效果，跟踪线索诱导的渴望，测量认知效果，检测持久性 神经和认知缺陷，监测戒断，睡眠障碍， 用药依从性，跟踪治疗进展和用药进展。 由于成像涉及的学科的性质和范围是复杂的，所以 新一代具有成像技术、多模式分析、 神经科学、药理学、成瘾药物和治疗需要更充分地 探索药物滥用的神经生物学基础并满足预期的需求 美国--我们的培训计划一直在填补这一空白。在过去14年里 我们已经成功地指导了一个综合的、多学科的药物滥用和大脑 由麦克莱恩医院/哈佛医学院支持的成像培训计划 麻省理工学院的马蒂诺斯生物医学成像中心。我们的节目 强调具有坚实基础的临床和转化性研究指南 磁共振基础[成像、功能和光谱学]、脑电波、正电子发射计算机断层扫描 以及最近的近红外光谱(NIRS)。培训的基础设施 该计划围绕两台西门子3T临床扫描仪(一台TIM Trio和一台Prisma)、 瓦里安4T临床扫描仪，9.4T小孔动物磁铁，低密度和高密度 EEG/ERP和Imagent近红外系统。动物和临床PET均可在我们的 MGH网站。我们的导师由NIDA、NIAAA和NIMH提供充足的资金，因此提供 为我们的实习生提供了独特的研究机会。我们的博士后培训 该计划旨在为学员提供为期2年或3年的培训 成像技术的基础知识，然后是四个不同研究中的一个 跟踪支持每个学员的特定职业目标：1)技术和 器械；2)基础-临床；3)临床-治疗；4)翻译。在……里面 通过与Martinos中心合作，我们提供同步PET/MRI培训。这个 脑影像和精神药理学教学训练与实践相结合 在各种非常成功的研究实验室中的应用为我们的学员提供 拥有利用广泛的脑成像技术的技能，当他们开始 下一个十年，关于药物和酒精如何影响大脑的研究。

LUKAS, SE Training in Drug Abuse and Imaging T32 DA015036-15 This is a proposal to continue with years 16-20 of a postdoctoral training program in brain imaging and drug and alcohol abuse. We have at our disposal a variety of brain imaging tools that have yielded valuable insights into reward systems and addiction. The need for such a dedicated program is driven by the emergence of new and innovative techniques to view both the anatomical and functional aspects of the brain under a variety of conditions related to drug and alcohol abuse such as: acute intoxicating effects, tracking cue-induced craving, measuring cognitive effects, detecting persistent neurological and cognitive defects, monitoring withdrawal, sleep disturbances, medication compliance, tracking treatment progress and medication development. Because the nature and spectrum of the disciplines involved in imaging are complex, a new breed of scientists with backgrounds in imaging technology, multimodal analyses, neuroscience, pharmacology, addiction medicine and treatment are needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated needs in the United States—our Training Program has been filling this void. Over the past 14 years we have successfully directed an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program that is supported by the McLean Hospital/Harvard Medical School and the Martinos Center for Biomedical Imaging at the MGH. Our program emphasizes both clinical and translational research directives that have solid foundations in magnetic resonance [imaging, functional and spectroscopy], EEG, PET and most recently Near Infrared Spectroscopy (NIRS). The infrastructure of the training program is built around two Siemens 3T clinical scanners (a TIM Trio and a Prisma), a Varian 4T clinical scanner, a 9.4T small bore animal magnet, both low and high density EEG/ERP and an Imagent NIRS system. Both animal and clinical PET is available at our MGH site. Our mentors are well funded by NIDA, NIAAA and NIMH and as such offer a unique breadth of research opportunities for our trainees. Our postdoctoral training program is structured to provide the trainees, over the course of 2 or 3 years, with the basics of imaging techniques, followed by placement in one of four distinct research tracks supporting each trainee's specific career goals: 1) Technology and Instrumentation; 2) Basic-Clinical; 3) Clinical-Treatment; and 4) Translational. In collaboration with the Martinos Center, we offer training in concurrent PET/MRI. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on how drugs and alcohol affect the brain.