UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

我们要求资金，以建立一个跨学科的培训计划，在血红蛋白疾病，基因组和 华盛顿大学及其附属机构的蛋白质组学。该计划的重点是准备 研究生的研究生涯包括血红蛋白疾病，基因组学，蛋白质组学的知识 和计算生物学。除了他们在血红蛋白疾病方面的研究培训外，受训人员还将 参与的项目包括发现基因组如何编码基因产品的信息 执行复杂的生物任务；测量和分析序列变化；开发技术以 适应高吞吐量的实验分析，并生成新的计算工具进行分析 地理和基因组数据。鉴于预期的教育背景和职业目标的广泛多样性 在我们的学员中，该项目强调高度个性化的培训和跨学科研究。一个 多学科教员小组，因其参与血球病、基因组学和 对于他们的研究和培训记录，将担任受训者的导师。资深科学家拥有 在血红蛋白疾病领域的杰出贡献将作为受训者的顾问 将在最初6个月的实验室轮换期间建议学员选择他们的课程作业 以及在选择他们的研究导师方面。他们还将在整个培训期间向学员提供建议。 目标是将重点放在基因组和蛋白质组学工具的应用上 关于血红蛋白疾病领域的问题。研究经验将与各种 授课课程和选修课。道德研究行为培训是该计划的一部分。广度 知识和计划凝聚力是通过学员参加两个专题研讨会系列来实现的，这两个研讨会的特点是 基因组研究和计算生物学，期刊俱乐部，正在进行的研究，以及各种主题 由编程人员领导的讨论小组。培训预计将持续4到5年，其中前三年将 由培训计划支持，其余由研究导师或KO8的研究资金支持 实习生的。‘

We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomicsand proteomics at the University of Washington and affiliated institutions. The program focuses onpreparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and coniputational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developingtechnologies to accommodate high throughputexperimental assays, and generating new computational tools to analyze gehbmic and prbteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A rtiultidisciplinary group of faculty, selected for their involvement in hemdglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record Ofcontributions in the field of hemoglobinopathies will serve as advisors of the trainees They will'advise the trainees in the initial 6 month period of laboratory rotations, iri selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keepingtheir focus on application of the genomicsand proteomics tools in answeringimportant questions in the field of hemoglobinopathies. Research experiencewill be complemented with a varietyof didactic courses arid electives. Training on ethical researchconduct is part of the program. Breadthof knowledge and program cohesion are achieved throughtrainee participation in two seminar series that feature genomic researchand computational biology,journal clubs,research in progress, and a variety oftopical discussion groupsled by programfaculty. Training is expectedto last 4 to 5 years of whichthe first three will be supportedby the training program and the remainingby research funds of research mentors or KO8s of the trainee's. ¿ '. '