UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

我们要求资金建立一个血红蛋白病、基因组学和 蛋白质组学在华盛顿大学和附属机构。该计划的重点是准备 研究生的研究生涯，包括血红蛋白病，基因组学，蛋白质组学的知识 和计算生物学。除了他们在血红蛋白病的研究培训，学员将 从事的项目包括发现基因组如何编码基因产物的信息， 执行复杂的生物任务;测量和分析序列变异;开发技术， 适应高通量实验分析，并产生新的计算工具来分析 基因组学数据。考虑到教育背景和职业目标的广泛多样性 在我们的学员中，该计划强调高度个性化的培训和跨学科的研究。一 多学科教师小组，选择他们参与血红蛋白病，基因组学和 他们将担任学员的导师。资深科学家， 在血红蛋白病领域的杰出贡献记录将作为学员的顾问， 在最初的6个月实验室轮换期间，将为学员提供建议， 以及选择他们的研究导师。他们亦会在整个训练期间向学员提供意见 他们的目标是把重点放在基因组学和蛋白质组学工具的应用上， 血红蛋白病领域的问题。研究经验将得到各种补充， 教学课程和选修课。伦理研究行为的培训是该计划的一部分。布雷德霍夫 通过学员参加两个系列研讨会， 基因组研究和计算生物学，期刊俱乐部，正在进行的研究，以及各种专题 讨论小组由programfaculty领导。培训预计将持续4到5年，其中前三年将 由培训计划和研究导师或KO 8的研究基金授予 实习生的。是的。'

We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomicsand proteomics at the University of Washington and affiliated institutions. The program focuses onpreparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and coniputational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developingtechnologies to accommodate high throughputexperimental assays, and generating new computational tools to analyze gehbmic and prbteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A rtiultidisciplinary group of faculty, selected for their involvement in hemdglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record Ofcontributions in the field of hemoglobinopathies will serve as advisors of the trainees They will'advise the trainees in the initial 6 month period of laboratory rotations, iri selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keepingtheir focus on application of the genomicsand proteomics tools in answeringimportant questions in the field of hemoglobinopathies. Research experiencewill be complemented with a varietyof didactic courses arid electives. Training on ethical researchconduct is part of the program. Breadthof knowledge and program cohesion are achieved throughtrainee participation in two seminar series that feature genomic researchand computational biology,journal clubs,research in progress, and a variety oftopical discussion groupsled by programfaculty. Training is expectedto last 4 to 5 years of whichthe first three will be supportedby the training program and the remainingby research funds of research mentors or KO8s of the trainee's. ¿ '. '