UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

UW/FHCRC 血红蛋白病、基因组学和蛋白质组学培训

• 批准号: 7475272
• 负责人: George Stamatoyannopoulos
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475272
• 关键词: Applications Grants; Appointment; Area; Arts; Back; Biochemistry; Bioethics Consultants; Biological; Biological Assay; Church; Class; Complement; Complex; Computational Biology; Consultations; DNA; DNA Sequence; Data; Diamond; Discipline; Educational Background; Educational process of instructing; Educational workshop; Equipment; Evaluation; Exposure to; Faculty; Feedback; Flow Cytometry; Fluorescence; Funding; Genetic Programming; Genome; Genomics; Goals; Grant; Hematology; Hemoglobinopathies; Institutes; Institution; Interdisciplinary Study; Joints; Journals; Knowledge; Laboratories; Laboratory Research; Literature; Location; Mass Spectrum Analysis; Measures; Medical; Mentors; Microfabrication; Microscopy; Monitor; Oral; Paper; Personal Satisfaction; Postdoctoral Fellow; Preparation; Progress Reports; Proteins; Proteomics; Public Speaking; Range; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Training; Robotics; Role; Rotation; Science; Senior Scientist; Sequence Analysis; Series; Students; Technology; Thinking; Training; Training Programs; Travel; Universities; Variant; Washington; Work; Writing; base; career; cohesion; computerized tools; day; experience; interest; member; micro-total analysis system; multidisciplinary; post-doctoral training; programs; skills; tool

DESCRIPTION (provided by applicant): We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomics and proteomics at the University of Washington and affiliated institutions. The program focuses on preparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and computational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developing technologies to accommodate high throughput experimental assays, and generating new computational tools to analyze genomic and proteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A multidisciplinary group of faculty, selected for their involvement in hemoglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record of contributions in the field of hemoglobinopathies will serve as advisors of the trainees They will advise the trainees in the initial 6 month period of laboratory rotations, in selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keeping their focus on application of the genomics and proteomics tools in answering important questions in the field of hemoglobinopathies. Research experience will be complemented with a variety of didactic courses and electives. Training on ethical research conduct is part of the program. Breadth of knowledge and program cohesion are achieved through trainee participation in two seminar series that feature genomic research and computational biology, journal clubs, research in progress, and a variety of topical discussion groups led by program faculty. Training is expected to last 4 to 5 years of which the first three will be supported by the training program and the remaining by research funds of research mentors or KO8s of the trainees.

描述（由申请人提供）：我们要求资金在华盛顿大学和附属机构建立在血红蛋白，基因组学和蛋白质组学方面的跨学科培训计划。该计划致力于为研究职业准备研究生涯，其中包括有关血红蛋白病，基因组学，蛋白质组学和计算生物学的知识。除了在血红蛋白病方面的研究培训外，学员还将参与项目，包括发现基因组如何编码基因产品的信息以执行复杂的生物学任务；测量和分析序列变化；开发技术以适应高通量实验测定，并生成新的计算工具来分析基因组和蛋白质组学数据。鉴于我们的受训者在教育背景和职业目标中的预期多样性，该计划强调了高度个性化的培训和跨学科研究。一个多学科的教师小组，因参与血红蛋白病，基因组学和原始培训记录而被选为受训者的导师。在血红蛋白病领域有良好贡献记录的高级科学家将担任学员的顾问，他们将在最初的6个月实验室轮换期间，选择课程工作以及选择研究导师的最初征询受训者。他们还将在整个培训期间为学员提供建议，目的是将重点放在基因组学和蛋白质组学工具的应用上，以回答血红蛋白病领域的重要问题。研究经验将与各种教学课程和选修课相辅相成。道德研究行为培训是该计划的一部分。知识和计划的凝聚力是通过学员参与两个研讨会系列来实现的，这些研讨会系列具有基因组研究和计算生物学，期刊俱乐部，正在进行的研究以及由计划教师领导的各种主题讨论小组。培训预计将持续4到5年，其中前三个将得到培训计划以及研究导师或学员的KO8的研究资金的剩余资金。