UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

描述（由申请人提供）：我们请求资助在华盛顿大学及其附属机构建立一个血红蛋白病、基因组学和蛋白质组学的跨学科培训项目。该计划的重点是准备研究生的研究生涯，包括血红蛋白病，基因组学，蛋白质组学和计算生物学的知识。除了在血红蛋白病方面的研究培训外，学员还将参与一些项目，包括发现基因组如何编码基因产物的信息以执行复杂的生物任务；序列变化的测量与分析；开发适应高通量实验分析的技术，并产生新的计算工具来分析基因组和蛋白质组学数据。鉴于学员在教育背景和职业目标方面的广泛多样性，该项目强调高度个性化的培训和跨学科的研究。由参与血红蛋白病、基因组学和蛋白质学研究并有培训记录的多学科教员组成的小组将担任受训者的导师。在血红蛋白病领域有突出贡献的资深科学家将担任受训人员的顾问，他们将在最初6个月的实验室轮转期间为受训人员提供建议，指导他们选择课程作业和选择研究导师。他们还将在整个培训期间为受训者提供建议，目标是将他们的重点放在基因组学和蛋白质组学工具的应用上，以回答血红蛋白病领域的重要问题。研究经验将辅以各种教学课程和选修课。伦理研究行为的培训是该计划的一部分。通过参与基因组研究和计算生物学的两个系列研讨会，期刊俱乐部，正在进行的研究以及由项目教师领导的各种主题讨论小组，学员可以获得广泛的知识和项目凝聚力。培训预计持续4至5年，其中前3年由培训计划支持，其余时间由研究导师或学员ko8的研究基金支持。

DESCRIPTION (provided by applicant): We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomics and proteomics at the University of Washington and affiliated institutions. The program focuses on preparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and computational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developing technologies to accommodate high throughput experimental assays, and generating new computational tools to analyze genomic and proteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A multidisciplinary group of faculty, selected for their involvement in hemoglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record of contributions in the field of hemoglobinopathies will serve as advisors of the trainees They will advise the trainees in the initial 6 month period of laboratory rotations, in selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keeping their focus on application of the genomics and proteomics tools in answering important questions in the field of hemoglobinopathies. Research experience will be complemented with a variety of didactic courses and electives. Training on ethical research conduct is part of the program. Breadth of knowledge and program cohesion are achieved through trainee participation in two seminar series that feature genomic research and computational biology, journal clubs, research in progress, and a variety of topical discussion groups led by program faculty. Training is expected to last 4 to 5 years of which the first three will be supported by the training program and the remaining by research funds of research mentors or KO8s of the trainees.