A platform for individualized nutritional therapy in Alzheimer's disease

阿尔茨海默病个体化营养治疗平台

• 批准号: 7510902
• 负责人: Gene L Bowman
• 金额: $ 12.78万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7510902
• 关键词: Academic Medical Centers; Affect; Aging; Alzheimer' s Disease; Antioxidants; Biological Markers; Cholesterol; Clinical; Clinical Research; Collection; Diagnosis; Dietary Intervention; Docosahexaenoic Acids; Eicosapentaenoic Acid; Elderly; Elevation; Enrollment; Environment; F2-Isoprostanes; Foundations; Funding; Genes; Goals; Homocysteine; Homocystine; Human; Hydroxycholesterols; Impaired cognition; Individual; Investigation; Longitudinal Studies; Master' s Degree; Memory; Mentored Patient-Oriented Research Career Development Award; Neurodegenerative Disorders; Nutrient; Nutritional; Nutritional Study; Nutritional Support; Nutritional status; Omega-3 Fatty Acids; Outcome Measure; Oxidative Stress; Population; Prevention; Public Health; Rate; Recommendation; Research; Research Infrastructure; Research Personnel; Risk; Risk Factors; Scientist; Severity of illness; Testing; Time; Training; Translating; Translational Research; United States National Institutes of Health; aging nutrition; cohort; design; mild neurocognitive impairment; neuroprotection; prevent; programs; sound

DESCRIPTION (provided by applicant): Gene Bowman, ND seeks funding for a mentored patient-oriented research career development award to obtain the training necessary to design and implement scientifically rigorous research. Dr. Bowman's goal is to become an independent clinician-scientist with concentration in nutrition, aging and memory. The environment is an academic medical center with a NIA funded Alzheimer's center, NIH funded Center for Clinical and Translational Research and a NIH funded Human Investigation Program providing infrastructure for both training and for conduct of research. The training plan includes: 1) obtaining a masters degree in clinical research, 2) continuing training in the diagnosis and management of neurodegenerative illnesses, and 3) conducting a study of nutritional risk factors in Non-Impaired Elderly, Mild Cognitive Impairment, and mild Alzheimer's disease in order to build a foundation for individualized nutritional intervention in the prevention or slowing the progression of neurodegenerative disease. The specific aims of the proposed research are 1) Develop a nutrient biomarker profile from subjects enrolled for longitudinal study in the NIA Aging and Alzheimer's Center at OHSU (Non-Impaired Elderly, Mild Cognitive Impairment and mild Alzheimer's disease), 2) Characterize the variability of the nutrient biomarker profile over 24 months in the three cohorts, 3) Examine the relationship between the nutrient biomarker profile and change in clinical parameters over 24 months in the three cohorts. This project will utilize well characterized existing cohorts, adding nutrient assessments to the existing battery of clinical outcome measures. The nutrient parameters to be studied include homocysteine and its determinants, antioxidants and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, and cholesterol. This training will provide a platform for Dr. Bowman's long-term goal of developing an individualized nutritional treatment to prevent or at least slow the rate of decline in Alzheimer's disease. Since there are few sound recommendations for nutritional intervention to prevent or treat Alzheimer's disease, and since the affected and at-risk US population continues to grow dramatically, this research has the potential for substantial public health impact.

描述（由申请人提供）：北达科他州吉恩·鲍曼（Gene Bowman）正在寻求资助一项以患者为导向的研究职业发展奖，以获得设计和实施科学严谨的研究所需的培训。鲍曼博士的目标是成为一名独立的临床科学家，专注于营养、衰老和记忆方面的研究。该环境是一个学术医疗中心，拥有 NIA 资助的阿尔茨海默病中心、NIH 资助的临床和转化研究中心以及 NIH 资助的人类研究计划，为培训和研究提供基础设施。培训计划包括：1）获得临床研究硕士学位，2）神经退行性疾病诊断和治疗方面的继续培训，3）对无障碍老年人、轻度认知障碍和轻度阿尔茨海默病的营养危险因素进行研究，为预防或减缓神经退行性疾病进展的个体化营养干预奠定基础。拟议研究的具体目标是 1) 从 OHSU 的 NIA 老龄化和阿尔茨海默病中心（非受损老年人、轻度认知障碍和轻度阿尔茨海默氏病）登记参加纵向研究的受试者中开发营养生物标志物概况，2) 表征三个队列中 24 个月内营养生物标志物概况的变异性，3) 检查营养素之间的关系 三个队列 24 个月内的生物标志物概况和临床参数变化。该项目将利用特征明确的现有队列，将营养评估添加到现有的一系列临床结果测量中。要研究的营养参数包括同型半胱氨酸及其决定因素、抗氧化剂和作为氧化应激标志物的 F2 异前列腺素、omega 3 脂肪酸二十二碳六烯酸和二十碳五烯酸以及胆固醇。 此次培训将为鲍曼博士的长期目标提供一个平台，即开发个性化的营养治疗方法，以预防或至少减缓阿尔茨海默病的衰退速度。由于很少有关于预防或治疗阿尔茨海默病的营养干预的合理建议，而且美国受影响和高危人群持续急剧增长，因此这项研究有可能对公共健康产生重大影响。