A platform for individualized nutritional therapy in Alzheimer's disease

描述（由申请人提供）：Gene Bowman， ND寻求资助以指导患者为导向的研究职业发展奖励，以获得设计和实施科学严谨研究所需的培训。鲍曼博士的目标是成为一名专注于营养、衰老和记忆的独立临床科学家。环境是一个学术医疗中心，拥有NIA资助的阿尔茨海默病中心，NIH资助的临床和转化研究中心以及NIH资助的人类调查项目，为培训和研究提供基础设施。培训计划包括：1)获得临床研究硕士学位；2)继续接受神经退行性疾病诊断和管理方面的培训；3)开展无损伤老年人、轻度认知障碍和轻度阿尔茨海默病的营养危险因素研究，为个性化营养干预预防或减缓神经退行性疾病的进展奠定基础。拟议研究的具体目的是：1)从OHSU NIA老龄化和阿尔茨海默病中心（非受损老年人，轻度认知障碍和轻度阿尔茨海默病）纵向研究的受试者中开发营养生物标志物概况；2)表征三个队列中24个月内营养生物标志物概况的可变性。3)检查三个队列中营养生物标志物谱与24个月内临床参数变化之间的关系。该项目将利用现有的具有良好特征的队列，将营养评估添加到现有的一系列临床结果测量中。要研究的营养参数包括同型半胱氨酸及其决定因素、抗氧化剂和F2异前列腺素（作为氧化应激的标志）、omega - 3脂肪酸二十二碳六烯酸和二十碳五烯酸以及胆固醇。

DESCRIPTION (provided by applicant): Gene Bowman, ND seeks funding for a mentored patient-oriented research career development award to obtain the training necessary to design and implement scientifically rigorous research. Dr. Bowman's goal is to become an independent clinician-scientist with concentration in nutrition, aging and memory. The environment is an academic medical center with a NIA funded Alzheimer's center, NIH funded Center for Clinical and Translational Research and a NIH funded Human Investigation Program providing infrastructure for both training and for conduct of research. The training plan includes: 1) obtaining a masters degree in clinical research, 2) continuing training in the diagnosis and management of neurodegenerative illnesses, and 3) conducting a study of nutritional risk factors in Non-Impaired Elderly, Mild Cognitive Impairment, and mild Alzheimer's disease in order to build a foundation for individualized nutritional intervention in the prevention or slowing the progression of neurodegenerative disease. The specific aims of the proposed research are 1) Develop a nutrient biomarker profile from subjects enrolled for longitudinal study in the NIA Aging and Alzheimer's Center at OHSU (Non-Impaired Elderly, Mild Cognitive Impairment and mild Alzheimer's disease), 2) Characterize the variability of the nutrient biomarker profile over 24 months in the three cohorts, 3) Examine the relationship between the nutrient biomarker profile and change in clinical parameters over 24 months in the three cohorts. This project will utilize well characterized existing cohorts, adding nutrient assessments to the existing battery of clinical outcome measures. The nutrient parameters to be studied include homocysteine and its determinants, antioxidants and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, and cholesterol. This training will provide a platform for Dr. Bowman's long-term goal of developing an individualized nutritional treatment to prevent or at least slow the rate of decline in Alzheimer's disease. Since there are few sound recommendations for nutritional intervention to prevent or treat Alzheimer's disease, and since the affected and at-risk US population continues to grow dramatically, this research has the potential for substantial public health impact.