Omega 3 Pufas for the Vascular Component of Age-Related Cognitive Decline

Omega 3 Pufa 治疗与年龄相关的认知衰退的血管成分

• 批准号: 8995859
• 负责人: Gene L Bowman
• 金额: $ 3.33万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8995859
• 关键词: Affect; Age; Age-associated memory impairment; Alzheimer' s Disease; Amyloid; Anisotropy; Atherosclerosis; Atrophic; Biological Markers; Blood Vessels; Brain; Cardiovascular Diseases; Cell Adhesion Molecules; Cellular Structures; Cerebrum; Clinical Trials; Cognition; Cognitive aging; Cohort Studies; Data; Dementia; Dietary Intervention; Diffusion Magnetic Resonance Imaging; Elderly; Enrollment; Epidemiology; Evaluation; Fish Oils; Functional disorder; Future; Health; Impaired cognition; Incidence; Inferior frontal gyrus; Inflammatory; Intake; Intercellular adhesion molecule 1; Intervention; Magnetic Resonance Imaging; Measures; Medial; Mediating; Mediator of activation protein; Metabolism; Microvascular Dysfunction; Modeling; Nutrient; Nutritional; Nutritional Support; Omega-3 Fatty Acids; Pathology; Pathway interactions; Persons; Placebos; Plasma; Polyunsaturated Fatty Acids; Population; Populations at Risk; Prevention trial; Process; Psyche structure; Psychometrics; Randomized; Research; Risk; Risk Factors; Safety; Stroke; Supplementation; Temporal Lobe; Testing; Thinking; Time; Vascular Endothelium; White Matter Disease; White Matter Hyperintensity; cognitive change; cognitive function; cohort; design; double-blind placebo controlled trial; endothelial dysfunction; executive function; experience; improved; indexing; instrumental activity of daily living; lipid metabolism; neuroimaging; neuropsychological; novel strategies; pilot trial; prevent; primary outcome; processing speed; skills; vascular contributions; white matter

DESCRIPTION (provided by applicant): The main objective of this study is to determine if omega 3 polyunsaturated fatty acids (pufas) can slow the accumulation of brain MRI derived white matter hyperintensities (WMH) over 3 years in a population at risk for dementia by advanced age, evidence of WMH and lower pufa status. This pilot trial is designed to collect preliminary data on pufa effects on total WMH progression, plasma biomarkers of endothelial function and rate of cognitive change over time. The study is a randomized, double-blind, placebo-controlled trial. Non- demented elders age 80 and older with WMH burden and lower plasma pufas will be enrolled. One hundred and fifty subjects will be randomized, half to pufa supplementation, and half to placebo over a 3 year term. Aim 1 will assess the effects of this nutritional therapy on WMH progression. Our hypothesis is that those randomized to pufas will appreciate less WMH progression. Aim 2 will assess the pufa effects on biomarkers of endothelial function as a potential modulator of the effects on total WMH and cognitive change. We hypothesize that pufas improve biomarkers of endothelial function. Aim 3 will collect preliminary data on the change in executive function and processing skills to inform the more definitive prevention trials in the future. We hypothesize that pufas slow vascular pathology mediated cognitive aging.

描述（由申请人提供）：本研究的主要目的是确定 omega 3 多不饱和脂肪酸 (pufa) 是否可以在高龄痴呆风险人群中减缓 3 年内脑部 MRI 衍生的白质高信号 (WMH) 的积累、WMH 的证据和较低 pufa 状态。该试点试验旨在收集有关多不饱和脂肪酸对总 WMH 进展、内皮功能血浆生物标志物以及认知随时间变化率的影响的初步数据。该研究是一项随机、双盲、安慰剂对照试验。 80 岁及以上、WMH 负担和血浆 pufa 较低的非痴呆老年人将被纳入。 150 名受试者将被随机分配，其中一半服用多脂肪酸补充剂，另一半服用安慰剂，为期 3 年。目标 1 将评估这种营养疗法对 WMH 进展的影响。我们的假设是，那些随机接受 pufa 的患者会发现 WMH 进展较少。目标 2 将评估多不饱和脂肪酸对内皮功能生物标志物的影响，作为对总 WMH 和认知变化影响的潜在调节剂。我们假设 pufa 可以改善内皮功能的生物标志物。目标 3 将收集有关执行功能和处理技能变化的初步数据，为未来更明确的预防试验提供信息。我们假设多不饱和脂肪酸可以减缓血管病理介导的认知衰老。