Omega 3 pufas for the vascular component of age-related cognitive decline.

描述（由申请方提供）：本研究的主要目的是确定ω-3多不饱和脂肪酸（pufas）是否可以在高龄、WMH证据和较低pufa状态的痴呆风险人群中减缓脑MRI衍生的白色高信号（WMH）在3年内的蓄积。该初步试验旨在收集PUFA对总WMH进展、内皮功能的血浆生物标志物和随时间推移的认知变化率的影响的初步数据。本研究是一项随机、双盲、安慰剂对照试验。年龄在80岁及以上、WMH负荷和较低血浆pufas的非痴呆老年人将入组。将对150名受试者进行随机分组，其中一半接受pufa补充剂，另一半接受安慰剂，为期3年。目的1将评估这种营养疗法对WMH进展的影响。我们的假设是，那些随机分配到pufas的人将欣赏较少的WMH进展。目的2将评估PUFA对内皮功能生物标志物的影响，作为对总WMH和认知变化影响的潜在调节剂。我们假设pufas改善了内皮功能的生物标志物。目标3将收集有关执行功能和处理技能变化的初步数据，为未来更明确的预防试验提供信息。我们假设pufas慢血管病理介导的认知老化。

DESCRIPTION (provided by applicant): The main objective of this study is to determine if omega 3 polyunsaturated fatty acids (pufas) can slow the accumulation of brain MRI derived white matter hyperintensities (WMH) over 3 years in a population at risk for dementia by advanced age, evidence of WMH and lower pufa status. This pilot trial is designed to collect preliminary data on pufa effects on total WMH progression, plasma biomarkers of endothelial function and rate of cognitive change over time. The study is a randomized, double-blind, placebo-controlled trial. Non- demented elders age 80 and older with WMH burden and lower plasma pufas will be enrolled. One hundred and fifty subjects will be randomized, half to pufa supplementation, and half to placebo over a 3 year term. Aim 1 will assess the effects of this nutritional therapy on WMH progression. Our hypothesis is that those randomized to pufas will appreciate less WMH progression. Aim 2 will assess the pufa effects on biomarkers of endothelial function as a potential modulator of the effects on total WMH and cognitive change. We hypothesize that pufas improve biomarkers of endothelial function. Aim 3 will collect preliminary data on the change in executive function and processing skills to inform the more definitive prevention trials in the future. We hypothesize that pufas slow vascular pathology mediated cognitive aging.