Cognitive Behavioral Treatment of Depression in ESRD PAtients on Dialysis

终末期肾病透析患者抑郁症的认知行为治疗

• 批准号: 7477668
• 负责人: Daniel Cukor
• 金额: $ 14.49万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477668
• 关键词: Affect; Arts; Behavior Therapy; Behavioral; Belief; Biological; Caring; Clinical; Clinical Research; Cognitive; Cognitive Therapy; Community Health; Comorbidity; Complex; Condition; Data; Depressed mood; Dialysis patients; Dialysis procedure; Discipline; Doctor of Philosophy; Effectiveness; End stage renal failure; Frequencies; Future; Health; Hemodialysis; Hypertension; Intervention; Laboratories; Life Style; Link; Longevity; Measures; Medical; Mental Depression; Mentorship; Methods; Modeling; Modification; Moods; Nephrology; Patients; Physical Dialysis; Population; Population Heterogeneity; Psychological Theory; Psychologist; Psychopathology; Purpose; Quality of life; Randomized; Research Methodology; Research Personnel; Rolfing; Standards of Weights and Measures; Testing; Training; Treatment Efficacy; Waiting Lists; base; depressive symptoms; design; dietary restriction; early /brief intervention /therapy; experience; follow-up; illness perceptions; improved; innovation; mortality; psychologic; psychosocial; skills

The purpose of this application is for Daniel Cukor, Ph.D. to transition to an independent investigator in the field of psychosocial nephrology. Depression in hemodialysis patients has been associated with lower quality of life, poor compliance to dietary restrictions, and an overall increase in mortality. This proposal would help Dr. Cukor, a trained Clinical Health Psychologist, test a Cognitive Behavioral Therapy (CBT) Intervention that has been specifically designed for an ethnically diverse ESRD population to reduce their levels of depressive affect and improve their compliance with a hemodialysis-healthy lifestyle. This is the first attempt at treating depression in ESRD patients with a controlled psychosocial intervention. Under the mentorship of Jeremy Coplan, MD, Paul Kimmel, MD, and Rolf Peterson, Ph.D., a didactic experience has been devloped to help Dr. Cukor further his skills in the disciplines of nephrology, psychological theory and intervention, as well as research methodology. The actual intervention is based on traditional CBT treatment for depression with modifications for an ESRD population based on Dr. Cukor's previous clinical experience. Overall, this study provides a model to test the efficacy of this intervention on hemodialysis patients versus wait-list controls. Eighty subjects will be randomized to either the intervention first condition or the wait list and then they will receive the 10 session intervention. Psychological, Biological, and Medical information will be gathered before and after the intervention as well as at follow-up to provide data on the subjects' mood, quality of life, behavioral compliance, psychopathology and the general effects of their illness. This project stands to contribute to the health of the community at large, as it could demonstrate the efficacy of an intervention that is designed to target depression and compliance in an ethnically diverse dialysis population. This could lend support to the belief that the relationship between depression and ESRD is bidirectional, meaning that an effective psychosocial intervention will not only impact depressive affect, compliance, quality of life, and illness perceptions, but also laboratory dialysis values and even possibly overall health. If if it is proven to be benficial, this targeted and brief intervention could be incorporated into standard of care for all depressed dialysis patients.

此申请的目的是针对Daniel Cukor博士。过渡到独立研究者 心理肾脏病领域。血液透析患者的抑郁与较低有关 生活质量，对饮食限制的依从性不佳以及死亡率的总体增加。这个建议 将帮助训练有素的临床健康心理学家Cukor博士测试认知行为疗法（CBT） 专门为种族多样化的ESRD人群设计的干预措施以减少其 抑郁症的影响水平，并提高其对血液透析健康的生活方式的遵守。这是第一个 尝试通过受控的社会心理干预治疗ESRD患者的抑郁症。在 医学博士杰里米·科普兰（Jeremy Coplan）的指导，医学博士保罗·金梅尔（Paul Kimmel）和罗尔夫·彼得森（Rolf Peterson） 被剥夺了帮助Cukor博士在肾脏学学科，心理理论和 干预以及研究方法。实际干预措施基于传统的CBT治疗 根据Cukor博士以前的临床经验，对ESRD人群进行了修改。 总体而言，这项研究提供了一个模型来测试这种干预对血液透析患者的功效 等待列表控件。八十个受试者将被随机分为干预第一条件或等待名单 然后他们将获得10个会话干预。心理，生物学和医学信息将 在干预之前和之后以及随访之前和之后收集，以提供有关受试者心情的数据， 生活质量，行为合规，心理病理学及其疾病的一般影响。 该项目将为整个社区的健康做出贡献，因为它可以证明功效 旨在针对种族多样化透析的抑郁和依从性的干预措施 人口。这可以支持以下信念，即抑郁症与ESRD之间的关系是 双向，这意味着有效的社会心理干预不仅会影响抑郁症的影响，还会影响 合规性，生活质量和疾病的看法，以及实验室透析价值，甚至可能 整体健康。如果被证明是贝的，则可以将这种针对性和简短的干预纳入 所有抑郁透析患者的护理标准。