Function of the Urethra in Continent Women

描述（由申请人提供）：本申请要求资金用于两个目的： 1)职业发展：申请人计划获得密歇根大学临床研究设计和统计分析理学硕士学位。职业目标包括短期和长期目标。 短期目标包括获得硕士学位，并在一位富有成效的临床研究人员的指导下开始一个创新的精心设计的以患者为导向的研究项目。长期目标包括发展成为一个独立的以患者为导向的研究人员，在电诊断和尿道功能方面具有专业知识，通过更好地理解方法和设计来提高研究能力，设计随访研究以预防和治疗尿道括约肌的神经肌肉损伤，提交R 01以资助此类研究，发展研究指导技能，开始培训下一代以患者为导向的临床研究人员。 2)研究计划：研究计划的具体目标是：1。使用同心针肌电图（EMG;定量运动单位分析）和电流感知阈值测试从尿道获取高质量的神经肌肉信号，以检验零假设，即在以下人群中尿道神经肌肉功能无差异：i）白人和非裔美国女性; ii）大陆和压力性失禁女性; iii）大陆未产妇和经产妇。 2.建立不同种族女性尿道括约肌功能的定量参数。将计算白人和非裔美国女性的EMG、当前感知阈值和尿道压力的规范范围。这些数据可以被其他中心用作参考数据。

DESCRIPTION (provided by applicant): This application requests funds for two purposes: 1) Career Development: The applicant plans to obtain a Master of Science degree in Clinical Research Design and Statistical Analysis from the University of Michigan. The career goals include short and long-term goals. Short-term goals include the obtaining the Master Degree and beginning an innovative well-designed patient-oriented research project under the mentorship of a highly productive clinical researcher. The long-term goals include developing into an independent patient-oriented researcher with expertise in electrodiagnosis and urethral function, enhancing research abilities with a better understanding of methodology and design, designing follow-up studies to prevent and treat neuromuscular injuries to the urethral sphincter, submission of an R01 to fund such studies, and developing research mentoring skills to begin training the next generation of patient-oriented clinical researchers. 2) Research Project: The specific aims of the research plan are: 1. To acquire high-quality neuromuscular signals from the urethra using concentric needle electromyography (EMG; with quantitative motor unit analysis) and current perception threshold testing to test the null hypothesis that there are no differences in urethral neuromuscular function in: i) Caucasian and African American women; ii) Continent and stress incontinent women; and iii) Continent nulliparous and parous women. 2. To establish quantitative parameters of urethral sphincter function in women of various races. Normative ranges will be calculated for EMG, current perception thresholds, and urethral pressures for Caucasian and African American women. These data can then be used by other centers as reference data.