Extending and enhancing an fMRI power analysis tool.

描述（由申请人提供）：拟议的研究旨在开发一个强大的，灵活的功率计算工具，用于规划组功能磁共振成像（FMRI）研究。 这将需要扩展FMRIPower的当前版本，FMRIPower是一个正在开发的软件工具，目前已列入NITRC数据库。 功效计算需要先前分析的结果，但灵活的功效分析模型可提高找到功能强大的研究设计的能力，从而以最低成本进行研究。 当前版本的FMRIPower仅允许从FMRIB软件库（FSL）输入，并且仅允许用户更改研究中的受试者数量。 通过结合我们以前开发的方法，我们将使FMRIPower可用于更广泛的软件包，包括统计参数映射（SPM）和功能神经影像分析（AFNI）包，我们将扩展功率模型，以允许受试者数量的波动以及每个受试者的运行次数和每次运行发生的刺激事件的数量。 NITRC网站将有助于分发和评估FMRIPower。 由此产生的工具将是未来功能磁共振成像研究规划的资产，这将导致更好和更经济有效地利用研究资金，因为功效分析有助于确保收集适当的样本量。 公共卫生相关性：拟议的研究旨在通过提供在组fMRI中进行灵活功率计算的方法来改善公共健康，以计划具有足够高功率的研究设计来检测效果，如果存在，同时保持在拟议的预算范围内。 目前缺乏灵活的软件来计算组功能磁共振成像研究的功效，这往往导致研究人员放弃功效计算或基于无关研究的功效的样本量，从而导致研究功效太低而无法检测效果或成本过高的研究。 我们免费提供的软件工具的开发将允许许多不同的功能磁共振成像软件包的用户进行功率分析的能力，使许多调整的研究设计，以最大限度地提高功率和最小化成本。

DESCRIPTION (provided by applicant): The proposed research aims to develop a powerful, flexible power calculation tool to be used for planning group functional magnetic resonance imaging (FMRI) studies. This will require extending the current version of FMRIPower, a software tool under development that is currently listed in the NITRC database. A power calculation requires results from a previous analysis, but flexible models for power analysis increase the ability to find a powerful study design that can be carried out for the lowest cost. The current version of FMRIPower only allows input from the FMRIB Software Library (FSL) and only allows users to alter the number of subjects in the study. By incorporating methods that we have previously developed, we will make FMRIPower accessible to a wider variety of software packages, including the Statistical Parametric Mapping (SPM) and Analysis of Functional NeuroImages (AFNI) packages, and we will extend the power model to allow fluctuations in the number of subjects as well as the number of runs per subject and the number of stimulus events that occur per run. The NITRC website will be helpful in distributing and assessing FMRIPower. The resulting tool will be an asset for the planning of future fMRI studies that will result in better and more cost- effective utilization of research funds, since power analyses help insure the appropriate sample size is collected. PUBLIC HEALTH RELEVANCE: The proposed research aims to improve public health by supplying the means to carry out a flexible power calculation in group fMRI to plan study designs with high enough power to detect an effect, if it is present, while staying within the proposed budget. The current lack of flexible software for calculating power for group fMRI studies often leads investigators to forego power calculation or base sample sizes on power from unrelated studies, leading to studies that are too underpowered to detect an effect or costly overpowered studies. The development of our freely available software tool will allow users of many different fMRI software packages to carry out power analyses with capabilities to make many adjustments to the study design in order to maximize power and minimize cost.