Targeted Research Training Core

描述(由申请人提供)：本补充申请描述了ERG联合研究培训计划的竞争性更新，名为职业暴露和敏感度生物标记物(BOES)。该计划的重点是为博士生和博士生提供跨学科研究培训，以开发和应用暴露在职业和环境危害中的人类群体中的生物标记。BOES培训计划的主要目标是培养高素质的博士生，使他们具备在职业环境中开发、评估和应用暴露、效应和易感性的分子和生化生物标记物所需的知识和技能。博士研究项目专注于当前职业健康中的问题，这些问题可以通过分子和生化生物标记物进行研究，并反映了与该项目附属的教师的专业知识。该项目的毕业生准备进入多个场所的研究、教学或监管职业，包括学术大学、研究机构、政府卫生机构和国际卫生组织。在过去的五年里，BOES的教职员工在这个项目领域平均每年为六名博士生提供咨询，而在2002年NIOSH基金开始之前，这些教职员工平均只为三到四名博士生提供咨询。更重要的是，BOES计划为这些学生提供了更明确的课程，并通过与ERG的联系与有相关兴趣的学生和教职员工进行互动。作为对先前审查的回应，本申请描述了该项目正在进行的学生研究和教师在快速开发新技术方面的专业知识。其他现有的资源，如具有蛋白质组学专业知识的教员和生物信息学课程，已正式纳入该计划。该项目提供的培训在职业卫生研究和实践中具有广泛的应用。研究的一般重要领域包括但不限于：更好地查明因果因素；更准确地描绘剂量-效应关系；开发最早查明不良影响的技术；对监测的科学基础作出贡献，包括生物监测和监测；在职业环境中合乎道德地使用生物标志物；评价预防措施，包括促进健康；了解职业病发生过程中涉及的重要病理生理机制。因此，项目毕业生所获得的专业知识适用于风险评估、生物监测、疾病病因学以及职业性人类疾病的诊断和预防。

DESCRIPTION (provided by applicant): This supplemental application describes the competing renewal of the ERG allied research training program entitled Biomarkers of Occupational Exposure and Susceptibility (BOES). The focus of this program is interdisciplinary research training for PhD and DrPH degree candidates in the development and application of biological markers in human populations exposed to occupational and environmental hazards. The main objective of the BOES Training Program is to graduate highly qualified doctoral students with the knowledge and skills necessary to develop, evaluate and apply molecular and biochemical biomarkers of exposure, effect and susceptibility in occupational settings. Doctoral research projects focus on current problems in occupational health that are amenable to study by molecular and biochemical biomarkers, and reflect the expertise of the program-affiliated faculty. Graduates from the program are prepared to enter research, teaching, or regulatory careers in several venues, including academic universities, research institutes, governmental health agencies and international health organizations. BOES faculty have advised an average of six doctoral students per year over the past five years in this program area, whereas these faculty advised an average of only three-to-four doctoral students prior to the beginning of NIOSH funding in 2002. More importantly, the BOES Program has provided a more defined curriculum for these students, as well as interaction with students and faculty with related interests through affiliation with the ERG. In response to the previous review, this application describes the program's ongoing student research and faculty expertise in rapidly developing new technologies. Other existing resources, such as faculty with expertise in proteomics and coursework in bioinformatics, have been formally incorporated into the Program. The training provided by this program has broad application in occupational health research and practice. General areas of importance for research include, but are not limited to: the better identification of causal factors; the more precise delineation of dose-effect relationships; the development of techniques for the earliest identification of adverse effects; contributions to the scientific basis of monitoring, including biologic monitoring and surveillance; the ethical use of biomarkers in occupational settings; the evaluation of preventive measures, including health promotion; and an understanding of important pathophysiologic mechanisms involved in the development of occupational disease. Thus, the expertise and knowledge gained by program graduates is applicable in risk assessment, biomonitoring, disease etiology and the diagnosis and prevention of human diseases of occupational origin.