Targeted Research Training Core

有针对性的研究培训核心

• 批准号: 7487655
• 负责人: JACQUELINE AGNEW
• 金额: $ 9.8万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487655
• 关键词: Targeted; Research; Training; Core

DESCRIPTION (provided by applicant): This supplemental application describes the competing renewal of the ERG allied research training program entitled Biomarkers of Occupational Exposure and Susceptibility (BOES). The focus of this program is interdisciplinary research training for PhD and DrPH degree candidates in the development and application of biological markers in human populations exposed to occupational and environmental hazards. The main objective of the BOES Training Program is to graduate highly qualified doctoral students with the knowledge and skills necessary to develop, evaluate and apply molecular and biochemical biomarkers of exposure, effect and susceptibility in occupational settings. Doctoral research projects focus on current problems in occupational health that are amenable to study by molecular and biochemical biomarkers, and reflect the expertise of the program-affiliated faculty. Graduates from the program are prepared to enter research, teaching, or regulatory careers in several venues, including academic universities, research institutes, governmental health agencies and international health organizations. BOES faculty have advised an average of six doctoral students per year over the past five years in this program area, whereas these faculty advised an average of only three-to-four doctoral students prior to the beginning of NIOSH funding in 2002. More importantly, the BOES Program has provided a more defined curriculum for these students, as well as interaction with students and faculty with related interests through affiliation with the ERG. In response to the previous review, this application describes the program's ongoing student research and faculty expertise in rapidly developing new technologies. Other existing resources, such as faculty with expertise in proteomics and coursework in bioinformatics, have been formally incorporated into the Program. The training provided by this program has broad application in occupational health research and practice. General areas of importance for research include, but are not limited to: the better identification of causal factors; the more precise delineation of dose-effect relationships; the development of techniques for the earliest identification of adverse effects; contributions to the scientific basis of monitoring, including biologic monitoring and surveillance; the ethical use of biomarkers in occupational settings; the evaluation of preventive measures, including health promotion; and an understanding of important pathophysiologic mechanisms involved in the development of occupational disease. Thus, the expertise and knowledge gained by program graduates is applicable in risk assessment, biomonitoring, disease etiology and the diagnosis and prevention of human diseases of occupational origin.

描述（由申请人提供）：本补充申请描述了名为职业暴露和易感性生物标志物（BOES）的ERG联合研究培训计划的竞争性更新。该计划的重点是为博士和博士学位候选人提供跨学科研究培训，以开发和应用生物标志物在暴露于职业和环境危害的人群中。BOES培训计划的主要目标是毕业高素质的博士生，他们具有开发，评估和应用职业环境中暴露，影响和易感性的分子和生物化学生物标志物所需的知识和技能。博士研究项目侧重于当前职业健康中的问题，这些问题适合通过分子和生物化学生物标志物进行研究，并反映了该计划附属教师的专业知识。从该计划的毕业生准备进入研究，教学，或在几个地点，包括学术大学，研究机构，政府卫生机构和国际卫生组织的监管职业。在过去的五年里，BOES教师平均每年为这个项目领域的六名博士生提供咨询，而这些教师在2002年NIOSH资助开始之前平均只为三到四名博士生提供咨询。更重要的是，BOES计划为这些学生提供了一个更明确的课程，以及通过与ERG的联系与学生和教师的相关利益的互动。作为对先前审查的回应，本申请描述了该计划正在进行的学生研究和教师在快速发展的新技术方面的专业知识。其他现有资源，如具有蛋白质组学专业知识的教师和生物信息学课程，已正式纳入该计划。该计划提供的培训在职业健康研究和实践中具有广泛的应用。研究的一般重要领域包括但不限于：更好地确定因果因素;更精确地描述剂量-效应关系;开发最早确定不良影响的技术;为监测的科学基础作出贡献，包括生物监测和监视;在职业环境中合乎道德地使用生物标志物;评估预防措施，包括健康促进;了解职业病发展中的重要病理生理机制。因此，专业毕业生获得的专业知识和知识适用于风险评估，生物监测，疾病病因学以及职业性人类疾病的诊断和预防。