Targeted Research and Academic Training of Nurses in Genomics

描述(由申请人提供)：这一机构NRSA的竞争性续签申请的目标是继续在遗传和基因组研究领域为博士后和博士后水平的护士提供教育和培训。基因组研究继续受益于改进的技术和大型研究努力，如人类基因组计划、国际HapMap计划、1000基因组计划和癌症基因组图谱计划。要使这些努力对临床相关问题产生影响，需要持续不断的个人干部接受最新的科学教育和培训，使他们能够将基因和基因组学纳入他们的研究轨迹。护士在弥合基因组研究和临床实践之间的差距方面具有独特的地位。他们在生命的所有阶段和所有临床领域与患者互动。他们的工作本质上是跨学科的。由于全国各地将基因组学纳入护理课程，更多的护士现在正在接受基因组学教育。然而，在进行尖端基因组研究方面进行长期实验室培训的机会仍然很少。这样的培训机会是必不可少的，因为护士科学家研究的几乎每一种疾病，包括匹兹堡大学护理学院的教职员工，都有基因成分。我们的目标是培养有才华的护士科学家，在他们职业生涯的开始阶段，开发与基因组学在改善患者预后方面的应用和评估相关的研究轨迹。该培训计划的目标是为博士后和博士后学员做好准备，通过授课课程、临床轮换、期刊俱乐部、研讨会、个性化实践、实验室经验和科学会议上的陈述，将基因组学纳入他们的研究轨道。该计划的目标侧重于以下方面的培训：1)将基因组学整合到理论/概念框架中；2)基因组学研究方法(例如，家庭研究、全基因组关联研究、基因表达研究)；3)基因组学实验室技术；以及4)基因组学的临床应用。为什么匹兹堡大学护理学院仍然是这种培训计划的理想环境的原因在申请书中进行了详细的阐述。

DESCRIPTION (provided by applicant): This competing renewal application for an Institutional NRSA has the goal of continuing to providing education and training to nurses at the predoctoral and postdoctoral level in the field of genetic and genomic research. Genomic research continues to benefit greatly from improved technologies and large research efforts such as the Human Genome Project, International HapMap project, the 1000 Genomes Project, and the Cancer Genome Atlas project. Bringing these efforts to bear upon clinically relevant issues requires that a continuous cadre of individuals receive state of the science education and training to allow them to incorporate genetic and genomics into their research trajectories. Nurses are uniquely positioned to bridge the gap between genomics research and clinical practice. They interact with patients at all stages of life, and in all clinical arenas. Their work is interdisciplinary by nature. More nurses are now receiving education in genomics because of the inclusion of genomics into nursing curricula across the country. Nevertheless, there continue to be few opportunities for long-term laboratory-based training in the conduct of cutting-edge genomics research. Such training opportunities are essential because nearly every condition studied by Nurse Scientists, including those on the faculty of the University of Pittsburgh, School of Nursing, has a genetic component. Our objective is to train talented Nurse Scientists, at the beginning stages of their careers, to develop research trajectories related to the application and evaluation of genomics in improving patient outcomes. The goal of the training program is to prepare predoctoral and postdoctoral trainees to incorporate genomics into their research trajectories using didactic courses, clinical rotations, journal clubs, seminars, individualized practica, laboratory experiences, and presentations at scientific meetings. Objectives of the program focus on training in: 1) the integration of genomics into theoretical / conceptual frameworks; 2) genomics research methodology (e.g., family studies, genome-wide association studies, gene expression studies); 3) genomics laboratory techniques; and 4) clinical application of genomics. Reasons why the School of Nursing at the University of Pittsburgh continues to be the ideal environment for such a training program are elaborated in the application.