Summer Research and Training Program in Environmental Health Sciences

描述(由申请人提供) 这项T35助学金申请旨在支持参与环境健康科学暑期研究和培训计划的医学生。拟议的计划将利用范德比尔特大学医学院的卓越研究设施、环境健康方面的优势以及以患者为中心的研究、现有的研究和培训基础设施，以及对继续发展生物医学研究和培训的机构承诺。请拨资金，每年资助10名博士前短期实习生(医学博士候选人)。 教官名单包括代表基础和临床研究学科的28名教职员工。学生将有机会参与不同领域的研究项目，包括活性氧和氮物种损伤细胞的机制，抗氧化剂的生物干预，DNA的化学损伤和遗传稳定性，遗传损伤诱导的信号通路，突变事件中的结构-功能关系，酶在影响化学物质损伤中的作用，以及金属(特别是锰和汞)引起的神经和肾脏损伤的机制。 该项目的主要目标是为处于学术生涯早期的医学生提供在环境健康科学领域的有意义的研究经验，并鼓励更多人走向内科-科学家的职业生涯。为了实现这一目标，该计划旨在1)为医学生提供进行导师指导的研究的机会，以便更好地了解该领域的生物医学研究和职业机会；2)为学生提供有关生物医学调查职业生涯所涉及的信息；3)提供一种氛围，鼓励和促进学生与环境健康科学广泛领域的各种知名研究人员和临床医生进行互动；以及4)使参与者对环境健康科学和该领域尚未解决的研究问题有一个全面和最新的概述。

DESCRIPTION (provided by applicant) This T35 grant application is designed to support medical students involved in a Summer Research and Training Program in Environmental Health Sciences. The proposed program will capitalize on the outstanding research facilities at the Vanderbilt University, School of Medicine, strengths in environmental health coupled with patient-oriented research, existing research and training infrastructure, and a demonstrated institutional commitment to the continued development of biomedical research and training. Funds are requested to support ten pre-doctoral short-term trainees per year (M.D. candidates). The list of preceptors includes twenty-eight faculty members representing basic and clinical research disciplines. Students will have the opportunity to participate in research projects in a variety of areas including mechanisms of cell damage by reactive oxygen and nitrogen species, biological intervention by antioxidants, chemical damage to DNA and genetic stability, signaling pathways induced as a response to genetic damage, structure-function relationships in mutagenic events, roles of enzymes in influencing damage from chemical agents, and mechanisms of neurological and renal damage induced by metals (especially manganese and mercury). The primary objective of this program is to provide a meaningful research experience in the field of environmental health sciences to medical students early in their academic careers and encourage more towards careers as physician-scientists. To achieve this objective, the program aims to 1) provide the medical student with the opportunity to conduct mentor-guided research in order to gain an improved understanding of biomedical research and career opportunities in the field; 2) provide students with information about what is involved in a career in biomedical investigation; 3) provide an atmosphere that encourages and facilitates student interaction with a diverse group of established investigators and clinicians in the broad area of environmental health sciences; and, 4) give participants a comprehensive and current overview of environmental health sciences and unsolved research problems in the field.