Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)

神经工程跨学科博士前培训项目（RMI）

• 批准号: 7485682
• 负责人: W. Mark Saltzman
• 金额: $ 43.57万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485682
• 关键词: Accounting; Address; Admission activity; Advertising; Advisory Committees; Animals; Applied Research; Area; Artificial Organs; Arts; Behavior; Biochemical; Biochemical Pathway; Biochemistry; Biocompatible Materials; Bioenergetics; Biological; Biological Neural Networks; Biological Sciences; Biology; Biomechanics; Biomedical Engineering; Biomedical Research; Biophysics; Biosensor; Biotechnology; Blood - brain barrier anatomy; Blood Vessels; Brain; Cell Line; Cells; Cellular biology; Cerebral cortex; Chemical Engineering; Chemicals; Class; Cloning; Cochlear Implants; Cognitive; Communities; Competence; Complex; Computer Vision Systems; Consult; Country; Cryoelectron Microscopy; Cytidine Monophosphate; Data; Deep Brain Stimulation; Depth; Development; Devices; Diagnosis; Diffusion; Discipline; Doctor of Philosophy; Drug Delivery Systems; Dyes; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Effectiveness; Electric Stimulation; Electrical Engineering; Electrodes; Elements; Engineering; Ensure; Environment; Equilibrium; Ethics; Evaluation; Event; Exercise Physiology; Exposure to; Facility Construction Funding Category; Faculty; Feedback; Fetal Tissues; Financial Support; Functional Magnetic Resonance Imaging; Future; Gene Structure; Genes; Genetic; Graduate Education; Grant; Group Meetings; Homeostasis; Hospitals; Hour; Human; Image; Imaging technology; Immersion Investigative Technique; In Vitro; Individual; Industry; Institution; Integrative Medicine; Interdisciplinary Study; Internships; Intervention; Investigation; Joints; Journals; Judgment; Kinetics; Laboratories; Laws; Lead; Learning; Left; Letters; Literature; Location; Magnetic Resonance; Magnetic Resonance Imaging; Mathematics; Measurement; Mechanics; Mediating; Medical; Medical Imaging; Membrane; Membrane Proteins; Mental disorders; Mentors; Methods; Microdialysis; Microfluidics; Mission; Modeling; Modems; Molecular; Molecular Machines; Monitor; Motor; Movement; Nature; Nervous System Physiology; Nervous system structure; Neuroanatomy; Neurobiology; Neurologic; Neurological Models; Neuronal Plasticity; Neurons; Neuropharmacology; Neurosciences; Neurotransmitters; New-Fill; Numbers; Oral; Oral Examination; Organ; Oxidative Phosphorylation; Paper; Participant; Pathway interactions; Perception; Performance; Peripheral Nervous System; Pharmacologic Substance; Pharmacology; Philosophy; Physics; Physiological; Physiology; Population; Positioning Attribute; Postdoctoral Fellow; Preparation; Procedures; Process; Production; Program Effectiveness; Program Evaluation; Property; Publications; Published Comment; Purpose; Qualifying; Rain; Range; Rate; Reaction; Reader; Readiness; Reading; Recording of previous events; Recruitment Activity; Recycling; Reporting; Research; Research Activity; Research Methodology; Research Personnel; Research Project Grants; Resources; Role; Rotation; Running; Schedule; Schools; Science; Scientist; Self-Evaluation Programs; Sensory; Series; Sorting - Cell Movement; Source; Speed; Spinal Cord; Stem cells; Structure; Students; System; Techniques; Technology; Testing; Text; Therapeutic; Thermodynamics; Thinking; Time; Tissue Engineering; Tissues; Training; Training Activity; Training Programs; Transmembrane Transport; Transport Process; United States National Institutes of Health; Universities; Vision; Visit; Visual system structure; Voting; Waiting Lists; Week; Work; Writing; awake; base; bioimaging; brain machine interface; career; chemotherapy; compound 351 A; controlled release; day; demographics; design; digital imaging; disorder prevention; experience; extracellular; falls; field study; fluid flow; human disease; image processing; in vivo; injured; innovation; insight; interest; journal article; lectures; lomustine/methotrexate/procarbazine protocol; medical schools; member; nerve stem cell; neurochemistry; neuroimaging; neuroimmunology; neurophysiology; neuroprosthesis; novel; optical imaging; peer; posters; pre-doctoral; professor; programs; prospective; prospectuses; protein structure; repaired; research and development; research study; response; role model; sensor; size; skills; statistics; strength training; symposium; teacher; theories; voltage

DESCRIPTION (provided by applicant): Quantitative approaches have a long history in the neurosciences, having contributed to the extraordinary progress made in understanding nervous system function at all levels of biological organization--from genes to behavior. Now, investigators from a variety of disciplines are beginning to incorporate engineering approaches in analyzing brain function, manipulating brain function, and building devices that duplicate or repair function lost in the injured brain. Into this rapidly evolving field of study, Yale proposes an Interdisciplinary Graduate Training Program in Neuroengineering. This proposal comes at an auspicious and important time in Yale's history: a new department of biomedical engineering was just formed, with a new research building under construction; a new center for magnetic resonance research was just opened with state-of-the-art research imaging capabilities; and the highly collaborative neuroscience community has grown to account for more than half of the university's biomedical research activity. Predoctoral students in the Neuroengineering Program would benefit from all of these institutional resources. By bringing 19 faculty members--representing 7 different departments and a large base of federally-supported individual and team grants--together in a unified training effort, the Neuroengineering program will: 1) prepare a group of scientists by full immersion in the disciplines of biomedical engineering and neuroscience; 2) create a new and vibrant interdisciplinary community at Yale; 3) develop new didactic courses and curriculum approaches for this field of study; and 4) implement a team approach for using quantitative biomedical engineering methods for solving complex problems in neuroscience. The students trained in this interdisciplinary program will be uniquely prepared to contribute to the academic and industrial workforce, and to speed progress towards diagnosis, treatment, and prevention of disease in the nervous system.

描述(由申请人提供)： 量化方法在神经科学中有着悠久的历史，在理解从基因到行为的所有生物组织水平上的神经系统功能方面取得了非凡的进步。现在，来自不同学科的研究人员开始将工程学方法应用于分析大脑功能、操纵大脑功能，以及建造复制或修复受损大脑中丢失的功能的设备。为了进入这个快速发展的研究领域，耶鲁大学提出了一个神经工程跨学科研究生培训计划。这项提议是在耶鲁历史上一个吉祥而重要的时刻提出的：一个新的生物医学工程系刚刚成立，一座新的研究大楼正在建设中；一个新的磁共振研究中心刚刚开放，拥有最先进的研究成像能力；高度合作的神经科学社区已经增长到占该大学生物医学研究活动的一半以上。神经工程项目的博士前学生将从所有这些机构资源中受益。通过将代表7个不同系和大量联邦政府资助的个人和团队补助金的19名教职员工聚集在一起进行统一的培训，神经工程计划将：1)通过完全沉浸在生物医学工程和神经科学的学科中培养一批科学家；2)在耶鲁创建一个新的、充满活力的跨学科社区；3)为这一研究领域开发新的教学课程和课程方法；以及4)实施团队方法，使用定量生物医学工程方法来解决神经科学中的复杂问题。在这一跨学科计划中接受培训的学生将做好独特的准备，为学术和工业劳动力做出贡献，并加快神经系统疾病的诊断、治疗和预防的进展。

项目成果

A tunable synthetic hydrogel system for culture of retinal ganglion cells and amacrine cells.

• DOI: 10.1016/j.actbio.2013.04.048
• 发表时间: 2013-08
• 期刊: ACTA BIOMATERIALIA
• 影响因子: 9.7
• 作者: Hertz, Jonathan;Robinson, Rebecca;Valenzuela, Daniel A.;Layik, Erin B.;Goldberg, Jeffrey L.
• 通讯作者: Goldberg, Jeffrey L.

O-space imaging: Highly efficient parallel imaging using second-order nonlinear fields as encoding gradients with no phase encoding.

O空间成像：使用二阶非线性场作为编码梯度而无需相位编码的梯度的高效并行成像。

• DOI: 10.1002/mrm.22425
• 发表时间: 2010-08
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Stockmann, Jason P.;Ciris, Pelin Aksit;Galiana, Gigi;Tam, Leo;Constable, R. Todd
• 通讯作者: Constable, R. Todd

Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines.

• DOI: 10.1088/0031-9155/58/6/1903
• 发表时间: 2013-03-21
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Fung EK;Carson RE
• 通讯作者: Carson RE

Optimization of PET-MR registrations for nonhuman primates using mutual information measures: a Multi-Transform Method (MTM).

• DOI: 10.1016/j.neuroimage.2012.08.051
• 发表时间: 2013-01-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Sandiego, Christine M.;Weinzimmer, David;Carson, Richard E.
• 通讯作者: Carson, Richard E.

Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier.

• DOI: 10.1111/j.1460-9568.2008.06567.x
• 发表时间: 2009-01
• 期刊: The European journal of neuroscience
• 作者: Rauch MF;Hynes SR;Bertram J;Redmond A;Robinson R;Williams C;Xu H;Madri JA;Lavik EB
• 通讯作者: Lavik EB