Mouse Pathobiology: Models of Human Disease

小鼠病理学：人类疾病模型

• 批准号: 7457649
• 负责人: MICHAEL D. LAIRMORE
• 金额: $ 41.53万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7457649
• 关键词: Modeling; Mus; human disease

DESCRIPTION (provided by applicant): In this competitive renewal proposal, we seek funds to continue to provide an outstanding environment for veterinarians (D.V.M. or V.M.D.) and D.V.M./PhDs to attain specific research and conceptual skills to develop and utilize mouse models of human disease. The training program has been highly successful in establishing the program exceeding all goals of the original proposed plan. Despite having training positions cut by NCRR the program has enrolled 11 DVMs. Of the 11 trainees supported over the first 4.5 years of the program, two were awarded NIH K Awards (K08 and K01), two have matriculated and are employed in biomedical or academic positions, and 9 are completing requirements for their Ph.D. degrees of which 5 currently are funded by the T-32 training grant. All veterinarians recruited into the program have outstanding academic records and we have added new experienced training faculty. Training courses, seminars, and workshops have created specialized and focused training opportunities. Specifically, veterinarian scientists will continue to be trained in state-of-the-art techniques to systematically evaluate the pathobiology of mouse models of human disease. The training program will be coordinated through an established graduate program in the College of Veterinary Medicine and supported by a unified group of basic and clinical scientists with ongoing collaborative programs at The Ohio State University and Children's Hospital in Columbus, Ohio. Trainees will gain knowledge and skills to fully understand and evaluate pathophysiologic alterations of murine models of human disease through both didactic coursework and applied training in pathology and molecular biology. In addition, trainees will interact with our multidisciplinary faculty to identify the range of research problems that use murine models. They will acquaint themselves with the ongoing basic and clinical research studies in the laboratories of the participating faculty, and select a research problem that utilizes a murine model for endpoint evaluation. Following the selection of a preceptor and research problem, the trainee will participate in the design and performance of experiments, as well as analysis and presentation of data regarding a murine model. Therefore, trainees will acquire a broad background in molecular biology, genetics, pathology, laboratory animal medicine, as well as research design methodology, to provide trainees the skills needed to work in research teams to fulfill national needs in the development of skilled scientists in mouse pathobiology.

描述（由申请人提供）：在此竞争性更新提案中，我们寻求资金继续为兽医（D.V.M. 或 V.M.D.）和 D.V.M./PhD 提供出色的环境，以获得开发和利用人类疾病小鼠模型的特定研究和概念技能。培训计划非常成功，超出了最初提出的计划的所有目标。尽管 NCRR 削减了培训职位，但该计划仍招收了 11 名 DVM。在该计划的前 4.5 年里，共有 11 名受训人员获得支持，其中两人获得了 NIH K 奖（K08 和 K01），两人已被录取并在生物医学或学术职位上工作，还有 9 人正在完成博士学位的要求。其中 5 个学位目前由 T-32 培训补助金资助。所有招募到该计划的兽医都有出色的学术记录，我们还增加了新的经验丰富的培训教师。培训课程、研讨会和讲习班创造了专门且集中的培训机会。具体来说，兽医科学家将继续接受最先进技术的培训，以系统地评估人类疾病小鼠模型的病理学。该培训计划将通过兽医学院已建立的研究生计划进行协调，并得到基础和临床科学家统一小组的支持，并与俄亥俄州立大学和俄亥俄州哥伦布儿童医院正在进行的合作计划。学员将通过病理学和分子生物学的教学课程和应用培训获得知识和技能，以充分理解和评估人类疾病小鼠模型的病理生理学改变。此外，学员将与我们的多学科教师互动，以确定使用小鼠模型的研究问题的范围。他们将熟悉参与教师实验室正在进行的基础和临床研究，并选择利用小鼠模型进行终点评估的研究问题。在选择导师和研究问题后，学员将参与实验的设计和执行，以及有关小鼠模型的数据的分析和呈现。因此，学员将获得分子生物学、遗传学、病理学、实验动物医学以及研究设计方法方面的广泛背景，为学员提供在研究团队中工作所需的技能，以满足国家培养小鼠病理学熟练科学家的需求。