Transport studies of particle beam biological effects

这项研究的目的是确定目前使用的放射生物效应(RBE)值 在质子放射治疗中是准确的，并且在整个照射体积中都被很好地理解，以提供 最有效的治疗方法。如果这些值被低估，这意味着接受质子治疗的患者 可能在肿瘤区域以及周围的健康组织中接受比所需剂量更高的剂量 目标区域。这些数值可能会受到次级粒子和反冲产生的影响 由于质子相互作用而形成的原子核。为了确定这一点，蒙特卡罗模拟使用了独特的原子核 将执行数据库和中能核模拟代码，并在几种情况下 进行了临床相关性测试。除了确定质子的RBE和空间变化外，我们还将 研究12C等离子在放射治疗中表现出的几个优点的RBE。近年来， 人们对使用这类离子进行治疗的兴趣有所增加。

The objective of this research is to determine if the radiobiological effectiveness (RBE) values used presently in proton radiotherapy are accurate and well understood throughout the irradiated volume to provide the most efficacious treatment. If these values are underestimated this means that patients treated with protons could be receiving higher doses than required in the tumor area as well as in the healthy tissue surrounding the target area. These values could be affected by the production of secondary particles as well as recoil nuclei due to proton interactions. In order to determine this, Monte Carlo simulations using unique nuclear data libraries and intermediate energy nuclear modeling codes will be performed and several circumstances of clinical relevance tested. In addition to determining the proton RBE and spatial variation, we will investigate the RBE of ions such as 12C that present several advantages for radiotherapy. In recent years, the interest in using such kinds of ions for therapy have increased.