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Transport studies of particle beam biological effects

粒子束生物效应的输运研究

基本信息

批准号：
7141693
负责人：
Angelica Aureliss Perez-Andujar
金额：
$ 3.02万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-12-01 至 2009-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7141693
关键词：
Admixture Affect Alpha Particles Angelica Area Behavior Biological Bladder Cancerous Cell Nucleus Cells Characteristics Charge Clinical Clinical effectiveness Code Data Deposition Depth Disadvantaged Distal Dose Dose-Rate Effectiveness Electrons Fellowship Hand Heavy Ions High-LET Radiation In Vitro Individual Ions Lateral Lead Left Length Libraries Light Linear Energy Transfer Malignant neoplasm of prostate Measurement Modality Modeling Names Neutrons Normal tissue morphology Nuclear Nuclear Energy Numbers Ocular Melanoma Organ Pathway interactions Patients Photons Production Property Prostate Protons Radiation Radiation therapy Range Rectum Relative (related person)Relative Biological Effectiveness Research Source Specific qualifier value System Techniques Testing Time Tissues Travel Tritons Variant Weight cell injury clinically relevant desire deuteron experience in vivo interest ionization particle particle beam prospective proton beam repaired response simulation tool treatment effect tumor

项目摘要

The objective of this research is to determine if the radiobiological effectiveness (RBE) values used presently in proton radiotherapy are accurate and well understood throughout the irradiated volume to provide the most efficacious treatment. If these values are underestimated this means that patients treated with protons could be receiving higher doses than required in the tumor area as well as in the healthy tissue surrounding the target area. These values could be affected by the production of secondary particles as well as recoil nuclei due to proton interactions. In order to determine this, Monte Carlo simulations using unique nuclear data libraries and intermediate energy nuclear modeling codes will be performed and several circumstances of clinical relevance tested. In addition to determining the proton RBE and spatial variation, we will investigate the RBE of ions such as 12C that present several advantages for radiotherapy. In recent years, the interest in using such kinds of ions for therapy have increased.

本研究的目的是确定目前使用的放射生物学有效性（RBE）值在质子放射治疗中，在整个照射体积中是准确的和很好理解的，最有效的治疗。如果这些值被低估，这意味着接受质子治疗的患者可能接受比肿瘤区域以及周围健康组织所需更高的剂量目标区域。这些值可能会受到次级粒子的产生以及反冲的影响由于质子相互作用。为了确定这一点，蒙特卡罗模拟使用独特的核数据库和中间能核模拟代码将被执行，并且在几种情况下，临床相关性测试。除了确定质子RBE和空间变化，我们将研究离子如12C的RBE，这些离子对放射治疗有几个优点。近年来，使用这种离子进行治疗的兴趣已经增加。