Transport studies of particle beam biological effects

粒子束生物效应的输运研究

• 批准号: 7064172
• 负责人: Angelica Aureliss Perez-Andujar
• 金额: $ 4.41万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064172
• 关键词: biological transport; computational biology; mathematical model; neoplasm /cancer radiation therapy; predoctoral investigator; proton beam; radiation therapy dosage; relative biological effectiveness

DESCRIPTION (provided by applicant): The objective of this research is to determine if the radiobiological effectiveness (RBE) values used presently in proton radiotherapy are accurate and well understood throughout the irradiated volume to provide the most efficacious treatment. If these values are underestimated this means that patients treated with protons could be receiving higher doses than required in the tumor area as well as in the healthy tissue surrounding the target area. These values could be affected by the production of secondary particles as well as recoil nuclei due to proton interactions. In order to determine this, Monte Carlo simulations using unique nuclear data libraries and intermediate energy nuclear modeling codes will be performed and several circumstances of clinical relevance tested. In addition to determining the proton RBE and spatial variation, we will investigate the RBE of ions such as 12C that present several advantages for radiotherapy. In recent years, the interest in using such kinds of ions for therapy have increased.

描述（由申请人提供）：本研究的目的是确定目前质子放疗中使用的放射生物学有效性（RBE）值是否准确，并在整个辐照体积中得到充分理解，以提供最有效的治疗。如果这些值被低估，这意味着接受质子治疗的患者可能会接受比肿瘤区域以及靶区域周围健康组织所需更高的剂量。这些值可能会受到次级粒子的产生以及由于质子相互作用而产生的反冲核的影响。为了确定这一点，将使用独特的核数据库和中能核建模代码进行蒙特卡罗模拟，并测试几种临床相关性情况。除了确定质子RBE和空间变化，我们将研究离子的RBE，如12 C，放射治疗的几个优势。近年来，使用这种离子进行治疗的兴趣已经增加。