The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception

精神分裂症妄想的神经基础：情绪感知的研究

• 批准号: 7487874
• 负责人: DAPHNE J HOLT
• 金额: $ 18.27万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487874
• 关键词: Address; Affective; Affective Symptoms; Amygdaloid structure; Animals; Behavior; Behavioral; Brain; Brain region; Clinical; Clinical Research; Cognitive; Cognitive deficits; Corpus striatum structure; Daphne plant; Data; Delusions; Detection; Early Diagnosis; Eating; Emotional; Evaluation; Event; Exhibits; Face; Facial Expression; Functional Magnetic Resonance Imaging; Goals; Hippocampus (Brain); Human; Individual; Instruction; Intervention; K-Series Research Career Programs; Lead; Learning; Link; Magnetic Resonance Imaging; Measures; Medial; Mentors; Methods; Modeling; National Institute of Mental Health; Patients; Perception; Pharmaceutical Preparations; Play; Prefrontal Cortex; Psychotic Disorders; Relative (related person); Research; Research Personnel; Rest; Role; Schizophrenia; Severities; Signal Detection Analysis; Spin Labels; Stimulus; Structure; Symptoms; Techniques; Temporal Lobe; Testing; Training; abstracting; affective neuroscience; base; blood oxygen level dependent; cognitive neuroscience; design; emotional stimulus; experience; hemodynamics; interest; method development; neuroimaging; patient oriented research; prevent; programs; psychologic; relating to nervous system; research study; response; therapy design; tool

DESCRIPTION (provided by applicant): This is an application for an NIMH Patient-Oriented Research Career Development Award (K-23) entitled "The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception." The candidate's interest is in the study of the neural correlates of psychotic symptoms in schizophrenia, with a specific focus on delusions. Previous studies indicate that patients with schizophrenia with active delusions exhibit abnormalities in emotional perception. A network of brain regions, which includes the amygdala, hippocampus, medial prefrontal cortex, and striatum, is active during emotional perception in healthy individuals. The candidate will test two hypotheses: 1) delusions arise from an increased tendency to attribute emotional significance to emotionally neutral or ambiguous information, and 2) this tendency results from abnormal neural activity within the network of brain regions involved in emotional perception. To address the research questions arising from this model, the candidate seeks training in cognitive and affective neuroscience, functional neuroimaging techniques, the statistical analyses of clinical, psychological and neuroimaging data, and the ethical conduct of clinical research. The proposed research plan, didactic courses, and individual instruction from mentors, advisors and consultants will help the candidate develop into an independent clinical researcher in the functional neuroimaging of emotional perception in schizophrenia. The candidate proposes to identify the specific abnormality in emotional perception in delusional schizophrenia patients using signal detection analyses to quantify a delusion-associated bias towards attributing emotional significance to neutral or ambiguous information. Experiments using two types of functional magnetic resonance imaging (blood oxygenation level dependent and arterial spin labeling) will be conducted to identify the changes in brain responses and resting neural activity associated with emotional perception abnormalities in delusional patients. Thus, the proposed experiments will test the candidate's model of delusions using the complementary techniques of cognitive neuroscience and functional magnetic resonance imaging. It is hoped that, by identifying perceptual and neural markers of delusions, these studies will lead to the development of methods for the detection of early, evolving psychosis. Such early detection methods would provide critical tools for the design of treatment interventions aimed at reducing the severity or preventing the onset of schizophrenia and other psychotic disorders.

描述（由申请人提供）：这是NIMH面向患者的研究职业发展奖（K-23）的申请，题为“精神分裂症的神经基础：情绪感知研究”。“候选人的兴趣是研究精神分裂症中精神病性症状的神经相关性，特别关注妄想。以往的研究表明，精神分裂症患者的积极妄想表现出异常的情绪知觉。健康人的大脑区域网络，包括杏仁核、海马体、内侧前额叶皮层和纹状体，在情绪感知过程中是活跃的。候选人将测试两个假设：1）妄想产生于将情感意义归因于情感中立或模糊信息的倾向增加，以及2）这种倾向是由涉及情感感知的大脑区域网络中的异常神经活动引起的。为了解决从这个模型中产生的研究问题，候选人寻求在认知和情感神经科学，功能性神经成像技术，临床，心理和神经成像数据的统计分析，以及临床研究的道德行为的培训。拟议的研究计划，教学课程，以及导师，顾问和顾问的个人指导将帮助候选人发展成为精神分裂症情绪感知功能神经成像的独立临床研究人员。候选人建议使用信号检测分析来确定妄想性精神分裂症患者情感感知的特定异常，以量化将情感意义归因于中性或模糊信息的妄想相关偏见。将进行使用两种类型的功能磁共振成像（血氧水平依赖性和动脉自旋标记）的实验，以确定与妄想患者的情绪感知异常相关的脑反应和静息神经活动的变化。因此，拟议的实验将测试候选人的妄想模型使用认知神经科学和功能磁共振成像的互补技术。希望通过识别错觉的知觉和神经标记，这些研究将导致早期发展的精神病检测方法的发展。这种早期检测方法将为旨在降低精神分裂症和其他精神障碍的严重程度或预防其发作的治疗干预措施的设计提供关键工具。