Alcohol Biomarkers in General Clinical Settings

背景：弗莱明博士在过去15年的大部分时间里都在进行酒精研究，指导酒精研究人员，照顾病人，并为医生和卫生保健领导人提供咨询。PI致力于继续他在以病人为导向的研究，指导，领导和病人护理领域的工作，他的学术生涯的其余部分。弗莱明博士致力于解决在酒精领域进行研究的医生科学家严重短缺的问题。K24应用目标：本申请的目标是为PI提供25%的时间来指导初级患者导向的研究人员，并开发新的临床研究生院课程，以及额外的25%的时间来将其研究计划扩展到酒精生物标志物，酒精相关创伤和ADHD儿童和胎儿酒精谱系障碍的药物治疗领域。如果K24在2005年7月获得，他将获得两个NIAAA资助的R 01赠款（R 01 AA 012522 -03和R 01 AA 014685 -01）的40%的时间，他的部门为他的临床工作提供10%的时间，拟议的K24赠款提供50%的时间。弗莱明博士正在完成2004年秋季完成的三项NIH赠款的后续工作（R21 AA 013368 -02、R 01 DA 013686 -02和R 01 AA 12664 - 01 A2）。 拟议的辅导活动：K24奖将使他能够扩大他在酒精领域的研究指导活动，包括新的研究员和研究生。这将使他能够花更多的时间在他最近获得的新的NIAAA T32赠款，这将资助每年三名医生科学家。该培训计划将侧重于增加进行NIAAA资助研究的医生数量。他计划开发1-2个关于如何进行酒精研究的新研究生院课程，重点是研究方法和分析策略。 意义：拟议的K24补充了当前的NIH路线图倡议。这笔赠款将促进弗莱明博士培养新的内科科学家的能力，为对临床研究感兴趣的硕士和博士生开发研究生课程，并提高他进行转化研究的能力。

DESCRIPTION (provided by applicant): Background: Dr. Fleming has spent the majority of the last 15 years conducting alcohol research, mentoring alcohol researchers, caring for patients and providing consultation to physicians and health care leaders. The PI is committed to continuing his work in the area of patient-oriented research, mentoring, leadership and patient care for the remainder of his academic career. Dr. Fleming is committed to addressing the critical shortage of physician scientists conducting research in the alcohol area. Goal of K24 application: The goal of this application is to provide the PI with 25% time to mentor junior patient oriented investigators and develop new graduate school courses in clinical research as well as an additional 25% time to expand his research program into the areas of alcohol biomarkers, alcohol-related trauma and medication treatment of children with ADHD and fetal alcohol spectrum disorder. If the K24 is awarded in July 2005, he would be funded 40% time on two NIAAA funded R01 grants (R01AA012522-03 and R01AA014685-01), 10% time by his department for his clinical work and 50% time by the proposed K24 grant. Dr. Fleming is completing follow up work on three NIH grants that were completed in the fall of 2004 (R21AA013368-02, R01DA013686-02 and R01AA12664-01A2). Proposed mentoring activities: The K24 award will allow him to expand his research mentoring activities in the alcohol area to include new research fellows and graduate students. It would allow him to spend more time on his recently awarded new NIAAA T32 grant which will fund three physician scientists per year. This training program will focus on increasing the number of physicians who conduct NIAAA funded research. He plans to develop 1-2 new graduate school courses on how to conduct alcohol research with a focus on research methodology and analysis strategies. Significance: The proposed K24 complements the current NIH Roadmap Initiatives. The grant will facilitate Dr. Fleming's ability to train new physician scientists, develop graduate-level courses for masters and PhD students interested in clinical research as well as increasing his capacity to conduct translational research.