Alcohol Biomarkers in General Clinical Settings

描述（由申请人提供）：背景：弗莱明博士在过去15年的大部分时间里都在进行酒精研究，指导酒精研究人员，照顾患者并向医生和卫生保健领导者提供咨询。PI致力于在他的学术生涯的剩余时间里继续他在以患者为导向的研究、指导、领导和患者护理领域的工作。弗莱明博士致力于解决在酒精领域进行研究的内科科学家严重短缺的问题。K24申请的目标：该申请的目标是为PI提供25%的时间来指导初级患者导向的研究人员和开发新的临床研究研究生课程，以及额外的25%的时间来扩展他的研究项目到酒精生物标志物，酒精相关创伤和ADHD儿童和胎儿酒精谱系障碍的药物治疗领域。如果K24在2005年7月被授予，他将获得NIAAA资助的两项R01基金（R01AA012522-03和R01AA014685-01）的40%的资助，10%的时间由他的部门用于他的临床工作，50%的时间由拟议的K24基金资助。弗莱明博士正在完成2004年秋季完成的三项NIH拨款的后续工作（R21AA013368-02， R01DA013686-02和R01AA12664-01A2）。

DESCRIPTION (provided by applicant): Background: Dr. Fleming has spent the majority of the last 15 years conducting alcohol research, mentoring alcohol researchers, caring for patients and providing consultation to physicians and health care leaders. The PI is committed to continuing his work in the area of patient-oriented research, mentoring, leadership and patient care for the remainder of his academic career. Dr. Fleming is committed to addressing the critical shortage of physician scientists conducting research in the alcohol area. Goal of K24 application: The goal of this application is to provide the PI with 25% time to mentor junior patient oriented investigators and develop new graduate school courses in clinical research as well as an additional 25% time to expand his research program into the areas of alcohol biomarkers, alcohol-related trauma and medication treatment of children with ADHD and fetal alcohol spectrum disorder. If the K24 is awarded in July 2005, he would be funded 40% time on two NIAAA funded R01 grants (R01AA012522-03 and R01AA014685-01), 10% time by his department for his clinical work and 50% time by the proposed K24 grant. Dr. Fleming is completing follow up work on three NIH grants that were completed in the fall of 2004 (R21AA013368-02, R01DA013686-02 and R01AA12664-01A2). Proposed mentoring activities: The K24 award will allow him to expand his research mentoring activities in the alcohol area to include new research fellows and graduate students. It would allow him to spend more time on his recently awarded new NIAAA T32 grant which will fund three physician scientists per year. This training program will focus on increasing the number of physicians who conduct NIAAA funded research. He plans to develop 1-2 new graduate school courses on how to conduct alcohol research with a focus on research methodology and analysis strategies. Significance: The proposed K24 complements the current NIH Roadmap Initiatives. The grant will facilitate Dr. Fleming's ability to train new physician scientists, develop graduate-level courses for masters and PhD students interested in clinical research as well as increasing his capacity to conduct translational research.