Post-Graduate Research Training Aligned with the NIMH Strategic Plan

项目摘要 在精神病学中，有一种强烈的需求，那就是促进能够申请的内科科学家的职业发展 神经科学的进展，应用于改善精神病患者的诊断和治疗。这个 精神病学对内科科学家的需求可能比其他医学领域更大，因为目前，我们 仍然几乎完全依赖于临床医生和患者之间的交互来获取信息 需要建立诊断，选择最合适的治疗方法，并评估其效果 治疗。有朝一日，我们也许能够将来自疾病机制知识的生物标记物应用于 帮助建立诊断和选择治疗，但即使是这些生物标志物也需要 使用内科科学家收集的临床信息进行验证，然后与患者的 临床叙述，以达到准确的诊断和制定有效的治疗计划。 西北大学范伯格医学院(NUFSM)拟议的R25项目旨在丰富 普通精神病学住院医师和临床研究员在平时培训期间的研究培训，因此 这些人保持并进一步巩固了他们对研究事业的承诺 与NIMH的战略规划相结合。我们的目标是支持他们的培训，使他们加强对 学术职业道路，在那里他们将获得研究设计、研究方法、数据等方面的关键技能 分析、助学金撰写和职业发展。申请参加我们的精神病学研究生培训计划 已经表现出对学术事业的浓厚兴趣和能力。因此，我们西北大学的实习生 具有丰富研究经验的优秀候选人。此外，目前在以下位置的教育资产 西北大学通过我们的CTSA、医生科学家培训计划、临床调查硕士 计划，以及各种跨部门的研究生计划可以被利用来增加 建议的R25计划。如果成功，该应用程序将创建唯一的R25医生-科学家培训 为中西部中部的精神病学住院医师提供的项目。

Project Summary There is a strong need in psychiatry to invigorate the career development of physician-scientists who can apply advances in neuroscience to applications that improve the diagnosis and treatment of psychiatric patients. The need for physician-scientists in psychiatry may be greater than in other fields of medicine, since at present, we still rely almost entirely on the clinical interaction between clinician and patients to obtain the information needed to establish a diagnosis, to select the most appropriate treatment, and to evaluate the effects of that treatment. One day we may be able to apply biomarkers derived from a knowledge of disease mechanisms to assist in establishment of a diagnosis and to select treatment, but even these biomarkers will need to be validated using clinical information collected by physician-scientists, and then integrated with the patient's clinical narrative to arrive at a precise diagnosis and develop an effective treatment plan. The proposed R25 program at Northwestern University Feinberg School of Medicine (NUFSM) aims to enrich research training for general psychiatry residents and clinical fellows during their usual period of training, so that these individuals maintain and further consolidate their commitment to a career in research that is aligned with the strategic plan of NIMH. We aim to support their training so that they strengthen their commitment to an academic career pathway, where they will acquire critical skills in study design, research methodologies, data analysis, grant writing and career development. Applicants to our post-graduate training programs in psychiatry already demonstrate strong interests and aptitudes for academic careers. Thus, our Northwestern trainees are excellent candidates for an enriched research experience. Also, educational assets currently in place at Northwestern through our CTSA, Physician Scientist Training Programs, Masters of Clinical Investigation program, and various interdepartmental graduate programs can be leveraged to increase the impact of the proposed R25 program. If successful, this application would create the only R25 physician-scientist training program for psychiatry residents in the central Midwest.