Post-Graduate Research Training Aligned with the NIMH Strategic Plan

项目摘要 在精神病学中，有一个强烈的需要，以振兴医生的职业发展，科学家谁可以申请 神经科学的进步应用于改善精神病患者的诊断和治疗。的 精神病学对医生科学家的需求可能比其他医学领域更大，因为目前，我们 仍然几乎完全依赖于临床医生和患者之间的临床互动来获得信息 需要建立诊断，选择最合适的治疗方法，并评估其效果。 治疗有一天，我们也许能够将从疾病机制的知识中获得的生物标志物应用于 帮助建立诊断和选择治疗，但即使是这些生物标志物也需要 使用医生-科学家收集的临床信息进行验证，然后与患者的 临床叙述，以达到准确的诊断和制定有效的治疗计划。 西北大学范伯格医学院（NUFSM）提出的R25计划旨在丰富 在一般精神病学住院医师和临床研究员的常规培训期间进行研究培训， 这些人保持并进一步巩固他们对研究事业的承诺， NIMH的战略计划。我们的目标是支持他们的培训，使他们加强他们的承诺， 学术职业途径，在那里他们将获得研究设计，研究方法，数据 分析，赠款写作和职业发展。申请我们的精神病学研究生培训课程的人 已经表现出强烈的兴趣和学术生涯的能力。因此，我们的西北学员是 丰富的研究经验的优秀候选人。此外，教育资产目前到位， 西北通过我们的CTSA，医生科学家培训计划，临床研究硕士 计划，和各种跨部门的研究生课程可以利用，以增加的影响， R25计划如果成功，这一应用将创造唯一的R25医生科学家培训 为中西部中部的精神病住院医师提供的项目。

Project Summary There is a strong need in psychiatry to invigorate the career development of physician-scientists who can apply advances in neuroscience to applications that improve the diagnosis and treatment of psychiatric patients. The need for physician-scientists in psychiatry may be greater than in other fields of medicine, since at present, we still rely almost entirely on the clinical interaction between clinician and patients to obtain the information needed to establish a diagnosis, to select the most appropriate treatment, and to evaluate the effects of that treatment. One day we may be able to apply biomarkers derived from a knowledge of disease mechanisms to assist in establishment of a diagnosis and to select treatment, but even these biomarkers will need to be validated using clinical information collected by physician-scientists, and then integrated with the patient's clinical narrative to arrive at a precise diagnosis and develop an effective treatment plan. The proposed R25 program at Northwestern University Feinberg School of Medicine (NUFSM) aims to enrich research training for general psychiatry residents and clinical fellows during their usual period of training, so that these individuals maintain and further consolidate their commitment to a career in research that is aligned with the strategic plan of NIMH. We aim to support their training so that they strengthen their commitment to an academic career pathway, where they will acquire critical skills in study design, research methodologies, data analysis, grant writing and career development. Applicants to our post-graduate training programs in psychiatry already demonstrate strong interests and aptitudes for academic careers. Thus, our Northwestern trainees are excellent candidates for an enriched research experience. Also, educational assets currently in place at Northwestern through our CTSA, Physician Scientist Training Programs, Masters of Clinical Investigation program, and various interdepartmental graduate programs can be leveraged to increase the impact of the proposed R25 program. If successful, this application would create the only R25 physician-scientist training program for psychiatry residents in the central Midwest.