Alcohol Biomarkers in General Clinical Settings

一般临床环境中的酒精生物标志物

• 批准号: 7682257
• 负责人: MICHAEL F. FLEMING
• 金额: $ 14.31万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7682257
• 关键词: Acute; Address; Admission activity; Adult; Alcohol dependence; Alcohol withdrawal syndrome; Alcoholic beverage heavy drinker; Alcohols; Area; Attention deficit hyperactivity disorder; Australia; Award; Biological Markers; Caring; Child; Clinical; Clinical Research; Commit; Complement; Consult; Consultations; Data; Databases; Development; Doctor of Philosophy; Early identification; Economics; Elective Surgical Procedures; Europe; FDA approved; Fetal Alcohol Spectrum Disorder; Frequencies; Funding; Germany; Goals; Grant; Guidelines; Healthcare; Hospital Costs; Hospitals; Inpatients; Intensive Care Units; Leadership; Length of Stay; Mechanical Ventilators; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); National Institute on Alcohol Abuse and Alcoholism; Nosocomial Infections; Operative Surgical Procedures; Patient Care; Patients; Persons; Pharmaceutical Preparations; Physicians; Policy Maker; Property; Psychometrics; Registries; Research; Research Methodology; Research Personnel; Respiratory Failure; Risk; Sampling; Schedule; Schools; Scientist; Sensitivity and Specificity; Services; Severities; Students; Surgeon; Testing; Time; Training; Training Programs; Translational Research; Trauma; United States National Institutes of Health; University Hospitals; Wisconsin; Work; addiction; alcohol related problem; alcohol research; alcohol risk; base; career; cost; design; diabetic; falls; follow-up; graduate student; interest; patient oriented; patient oriented research; prevent; programs; research study; tool

DESCRIPTION (provided by applicant): Background: Dr. Fleming has spent the majority of the last 15 years conducting alcohol research, mentoring alcohol researchers, caring for patients and providing consultation to physicians and health care leaders. The PI is committed to continuing his work in the area of patient-oriented research, mentoring, leadership and patient care for the remainder of his academic career. Dr. Fleming is committed to addressing the critical shortage of physician scientists conducting research in the alcohol area. Goal of K24 application: The goal of this application is to provide the PI with 25% time to mentor junior patient oriented investigators and develop new graduate school courses in clinical research as well as an additional 25% time to expand his research program into the areas of alcohol biomarkers, alcohol-related trauma and medication treatment of children with ADHD and fetal alcohol spectrum disorder. If the K24 is awarded in July 2005, he would be funded 40% time on two NIAAA funded R01 grants (R01AA012522-03 and R01AA014685-01), 10% time by his department for his clinical work and 50% time by the proposed K24 grant. Dr. Fleming is completing follow up work on three NIH grants that were completed in the fall of 2004 (R21AA013368-02, R01DA013686-02 and R01AA12664-01A2). Proposed mentoring activities: The K24 award will allow him to expand his research mentoring activities in the alcohol area to include new research fellows and graduate students. It would allow him to spend more time on his recently awarded new NIAAA T32 grant which will fund three physician scientists per year. This training program will focus on increasing the number of physicians who conduct NIAAA funded research. He plans to develop 1-2 new graduate school courses on how to conduct alcohol research with a focus on research methodology and analysis strategies. Significance: The proposed K24 complements the current NIH Roadmap Initiatives. The grant will facilitate Dr. Fleming's ability to train new physician scientists, develop graduate-level courses for masters and PhD students interested in clinical research as well as increasing his capacity to conduct translational research.

描述(由申请人提供)：背景：在过去15年的大部分时间里，弗莱明博士从事酒精研究，指导酒精研究人员，照顾病人，并为医生和卫生保健负责人提供咨询。在他余下的学术生涯中，PI致力于继续他在以患者为导向的研究、指导、领导力和患者护理领域的工作。弗莱明博士致力于解决在酒精领域开展研究的内科科学家的严重短缺问题。K24应用程序的目标：此应用程序的目标是为PI提供25%的时间来指导以患者为导向的初级调查人员，并开发新的研究生临床研究课程，以及额外25%的时间来将其研究计划扩展到酒精生物标记物、酒精相关创伤以及ADHD和胎儿酒精谱系障碍儿童的药物治疗领域。如果K24在2005年7月获奖，他将在NIAAA资助的两个R01拨款(R01AA012522-03和R01AA014685-01)上获得40%的时间，他的部门将为他的临床工作提供10%的时间，而拟议的K24拨款将获得50%的时间。Fleming博士正在完成2004年秋季完成的三项NIH赠款的后续工作(R21AA013368-02、R01DA013686-02和R01AA12664-01A2)。 建议的指导活动：K24奖将使他能够扩大他在酒精领域的研究指导活动，将新的研究员和研究生包括在内。这将使他有更多的时间在他最近获得的NIAAA T32新拨款上，这笔拨款将每年资助三名内科科学家。这项培训计划将侧重于增加进行NIAAA资助的研究的医生数量。他计划在研究生院开发1-2门关于如何进行酒精研究的新课程，重点是研究方法和分析策略。 意义：拟议的K24是对目前NIH路线图倡议的补充。这笔赠款将促进弗莱明博士培养新的内科科学家的能力，为对临床研究感兴趣的硕士和博士生开发研究生水平的课程，以及提高他进行转化性研究的能力。